Determination of rhodamine 123 by sequential injection technique for pharmacokinetic studies in the rat placenta

The sequential injection (SIA) technique was applied in pharmacokinetic studies of the transporter-mediated passage of a model substrate, rhodamine 123 (Rho123), through the dually perfused rat term placenta. The method described was used for real-time monitoring of Rho123 concentrations in both the...

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Veröffentlicht in:	Talanta (Oxford) 2002-12, Vol.58 (6), p.1145-1149
Hauptverfasser:	Sklenářová, H, Pávek, P, Šatı́nský, D, Solich, P, Karlı́ček, R, Štaud, F, Fendrich, Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological and medical sciences Fluorescence General pharmacology Medical sciences P-glycoprotein Pharmacology. Drug treatments Placental barrier Rhodamine 123 Sequential injection
Online-Zugang:	Volltext
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