The role of carbonic anhydrase IX in hypoxia control in OSCC

Tumoral microenvironments play a key role in the evolution of solid tumors. Tumor hypoxia is actively involved in the promotion of genetic instability, the invasive capacity of tumor cells, metastasis, and a worsening of the clinical evolution. Endogenous hypoxia markers are controlled by hypoxia‐re...

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Veröffentlicht in:	Journal of oral pathology & medicine 2013-01, Vol.42 (1), p.1-8
Hauptverfasser:	Pérez-Sayáns, Mario, Supuran, Claudiu T., Pastorekova, Silvia, Suárez-Peñaranda, José Manuel, Pilar, Gayoso-Diz, Barros-Angueira, Francisco, Gándara-Rey, José Manuel, García-García, Abel
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm - biosynthesis Antigens, Neoplasm - genetics Antigens, Neoplasm - physiology Antineoplastic Agents Biological and medical sciences CA-IX Carbonic Anhydrase IX Carbonic anhydrases Carbonic Anhydrases - biosynthesis Carbonic Anhydrases - genetics Carbonic Anhydrases - physiology Carcinoma, Squamous Cell - enzymology Dentistry Drug Resistance, Neoplasm Erythropoietin - physiology Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Glucose Transporter Type 1 - biosynthesis Glucose Transporter Type 1 - physiology Head and Neck Neoplasms - enzymology Humans Hypoxia Hypoxia - enzymology Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis Hypoxia-Inducible Factor 1, alpha Subunit - physiology Ki-67 Antigen - biosynthesis Ki-67 Antigen - physiology Medical sciences Mouth Neoplasms - enzymology Neovascularization, Pathologic Oral squamous cell carcinoma Otorhinolaryngology. Stomatology Radiation Tolerance Receptors, Erythropoietin - physiology Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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