Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway

FAM3B, also named PANDER, is a cytokine-like protein identified in 2002. Previous studies showed that FAM3B regulates glucose and lipid metabolism through interaction with liver and endocrine pancreas. FAM3B is also expressed by other tissues but its basic function is unclear. In this study, we foun...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2013-03, Vol.45 (3), p.684-691
Hauptverfasser:	Mou, Haiwei, Li, Zongmeng, Yao, Pengle, Zhuo, Shu, Luan, Wei, Deng, Bo, Qian, Lihua, Yang, Mengmei, Mei, Hong, Le, Yingying
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - genetics Caspase Cell viability Cytokines - biosynthesis Cytokines - genetics FAM3B Gene Expression Regulation, Neoplastic Gene Knockdown Techniques HCT116 Cells Humans Mdm2 Mice Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasms - genetics Neoplasms - metabolism p53 PANDER Phosphorylation Proto-Oncogene Proteins c-mdm2 - metabolism Signal Transduction Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - genetics
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