Changes in protein dynamics of the DNA repair dioxygenase AlkB upon binding of Fe(2+) and 2-oxoglutarate

The Escherichia coli DNA repair enzyme AlkB is a 2-oxoglutarate (2OG)-dependent Fe(2+) binding dioxygenase that removes methyl lesions from DNA and RNA. To date, nine human AlkB homologues are known: ABH1 to ABH8 and the obesity-related FTO. Similar to AlkB, these homologues exert their activity on...

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Veröffentlicht in:	Biochemistry (Easton) 2012-04, Vol.51 (16), p.3334-3341
Hauptverfasser:	Bleijlevens, Boris, Shivarattan, Tara, van den Boom, Kim S, de Haan, Annett, van der Zwan, Gert, Simpson, Pete J, Matthews, Steve J
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoproteins - chemistry Apoproteins - genetics Apoproteins - metabolism Catalysis Catalytic Domain Circular Dichroism Coenzymes - chemistry Coenzymes - metabolism DNA Repair DNA, Bacterial - chemistry DNA, Bacterial - metabolism Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Ferrous Compounds - chemistry Ferrous Compounds - metabolism Ketoglutaric Acids - chemistry Ketoglutaric Acids - metabolism Mixed Function Oxygenases - chemistry Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism Protein Binding Protein Structure, Secondary
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