Ligand binding of PDZ domains has various roles in the synaptic clustering of SAP102 and PSD-95

► Ligand binding-deficient PDZ domains enhance the synaptic clustering of SAP102. ► PDZ domains play distinct roles in the synaptic clustering of SAP102 and PSD-95. ► Binding of NMDAR with SAP102 is required for its efficient synaptic clustering. Synapse-associated protein 102 (SAP102) and postsynap...

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Veröffentlicht in:	Neuroscience letters 2013-01, Vol.533, p.44-49
Hauptverfasser:	Minatohara, Keiichiro, Ichikawa, Sho-hei, Seki, Tatsuya, Fujiyoshi, Yoshinori, Doi, Tomoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CHO Cells Cricetinae Cricetulus Deficient mutant Disks Large Homolog 4 Protein Guanylate Kinases - genetics Guanylate Kinases - metabolism Hippocampus - metabolism Ligands Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mutation Neurons - metabolism NMDA receptor PDZ domain PDZ Domains Postsynaptic density Protein Binding Protein Transport PSD-MAGUK Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - metabolism SAP102 Synapses - metabolism Synaptic clustering
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