A new single-photon emission computed tomography (SPECT) imaging agent for serotonin transporters: [125I]Flip-IDAM, (2-((2-((dimethylamino)methyl)-4-iodophenyl)thio)phenyl)methanol

New ligands for in vivo brain imaging of serotonin transporter (SERT) with single photon emission tomography (SPECT) were prepared and evaluated. An efficient synthesis and radiolabeling of a biphenylthiol, FLIP-IDAM, 4, was accomplished. The affinity of FLIP-IDAM was evaluated by an in vitro inhibi...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2013-02, Vol.23 (3), p.869-872
Hauptverfasser:	Zheng, Pinguan, Lieberman, Brian P., Ploessl, Karl, Lemoine, Laetitia, Miller, Sara, Kung, Hank F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzylamines - chemical synthesis Benzylamines - chemistry binding capacity binding sites Brain Brain mapping Cerebellum Chromatography, High Pressure Liquid Computed tomography Diphenyl sulfide humans hypothalamus image analysis intravenous injection Iodine Radioisotopes - chemistry Kinetics methanol Molecular Structure Neuroimaging Protein Binding Radioisotopes radiolabeling Radiopharmaceuticals - chemistry Rats serotonin Serotonin Plasma Membrane Transport Proteins - chemistry Serotonin transporter Single photon emission computed tomography SPECT Sulfides - chemical synthesis Sulfides - chemistry Tomography, Emission-Computed, Single-Photon transporters
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