Clinical Application for Intra-coronary NanoDDS Devices

Drug eluting stent on the market at present is feared about serious side effects after use (Acute coronary syndrome caused by delayed thrombosis). It is suggested that delayed thrombosis comes from inflammatory reaction, fibrin deposition, and delayed re-endothelialization. We have already succeeded...

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Veröffentlicht in:Drug Delivery System 2012/09/30, Vol.27(4), pp.275-282
Hauptverfasser: Nakano, Kaku, Yufu, Takeo, Egashira, Kensuke
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container_title Drug Delivery System
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creator Nakano, Kaku
Yufu, Takeo
Egashira, Kensuke
description Drug eluting stent on the market at present is feared about serious side effects after use (Acute coronary syndrome caused by delayed thrombosis). It is suggested that delayed thrombosis comes from inflammatory reaction, fibrin deposition, and delayed re-endothelialization. We have already succeeded in the development of stent platform that has the function of Nano DDS using electro-deposition coating technology. In this review, we summarize the results of Pulse-Wave Infusion Catheter and statin nanoparticle eluting stent acquiring Proof of Concept by the porcine coronary-arteries models, with describing the outline of stent platform that has the function of Nano DDS.
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subjects Animal models
Biocompatible Polymer
Delayed in-stent Restenosis
Drug Eluting Stent
Electrodepotion Coating Technology
Nanotechnology
Pleiotropic Effects
Poly (lactic-co-glycolic acid)
Statin
title Clinical Application for Intra-coronary NanoDDS Devices
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