Additional acetyl cholinesterase inhibitory property of diaryl pyrazoline derivatives

MAO-B and AChE are the two validated targets for Alzheimer’s disease. In pursuit of a single molecule hitting both the targets, we explored a set of previously reported extremely potent MAO-B selective inhibitors, for their additional AChE inhibitory activity. We performed molecular docking studies...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2013-02, Vol.23 (3), p.702-705
Hauptverfasser:	Mishra, Nibha, Sasmal, Dinakar
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholineesterase Acetylcholinesterase - metabolism Alzheimer disease Amine oxidase (flavin-containing) Binding Sites chemistry Cholinesterase Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Docking Dual inhibitors Enzyme Activation - drug effects Enzymes Humans Models, Molecular Molecular Structure Monoamine oxidase Monoamine Oxidase - metabolism Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacology
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