An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression

DNA Ligase IV is responsible for sealing of double-strand breaks (DSBs) during nonhomologous end-joining (NHEJ). Inhibiting Ligase IV could result in amassing of DSBs, thereby serving as a strategy toward treatment of cancer. Here, we identify a molecule, SCR7 that inhibits joining of DSBs in cell-f...

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Veröffentlicht in:	Cell 2012-12, Vol.151 (7), p.1474-1487
Hauptverfasser:	Srivastava, Mrinal, Nambiar, Mridula, Sharma, Sheetal, Karki, Subhas S., Goldsmith, G., Hegde, Mahesh, Kumar, Sujeet, Pandey, Monica, Singh, Ram K., Ray, Pritha, Natarajan, Renuka, Kelkar, Madhura, De, Abhijit, Choudhary, Bibha, Raghavan, Sathees C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animal models Animals Apoptosis Cancer Cell Line, Tumor Disease Models, Animal DNA DNA Breaks, Double-Stranded DNA End-Joining Repair - drug effects DNA Ligase ATP DNA Ligases - antagonists & inhibitors DNA Ligases - chemistry DNA Ligases - genetics Double-strand break repair Drug Design Drug Resistance, Neoplasm Humans Lymphocytes - drug effects Lymphoma - drug therapy Lymphoma - pathology Male Mice Mice, Inbred BALB C Mice, Nude Models, Molecular Molecular Sequence Data Neoplasms - drug therapy Neoplasms - pathology Non-homologous end joining Protein Structure, Tertiary Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - therapeutic use Radiation Tolerance Rats Schiff Bases - chemical synthesis Schiff Bases - chemistry Schiff Bases - therapeutic use Sequence Alignment Tumors
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