HCV superinfection and reinfection
The majority of acute HCV infections progress to chronicity, implying that the immune response is unable to clear virus in most instances. Reinfection with a second strain of HCV after clearance of an initial infection has been reported in several recent studies. Moreover, individuals with HCV infec...
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| Veröffentlicht in: | Antiviral therapy 2012, Vol.17 (7), p.1443-1448 |
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| container_title | Antiviral therapy |
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| creator | BLACKARD, Jason T |
| description | The majority of acute HCV infections progress to chronicity, implying that the immune response is unable to clear virus in most instances. Reinfection with a second strain of HCV after clearance of an initial infection has been reported in several recent studies. Moreover, individuals with HCV infection may be at risk of HCV superinfection with a second strain of HCV even after the establishment of persistent infection and the development of an immunological response to the initial virus. In vivo and in vitro data regarding HCV reinfection and superinfection, including the clinical consequences of these phenomena and the impact they have on vaccines require consideration in future studies. |
| doi_str_mv | 10.3851/IMP2460 |
| format | Article |
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Reinfection with a second strain of HCV after clearance of an initial infection has been reported in several recent studies. Moreover, individuals with HCV infection may be at risk of HCV superinfection with a second strain of HCV even after the establishment of persistent infection and the development of an immunological response to the initial virus. In vivo and in vitro data regarding HCV reinfection and superinfection, including the clinical consequences of these phenomena and the impact they have on vaccines require consideration in future studies.</description><identifier>ISSN: 1359-6535</identifier><identifier>EISSN: 2040-2058</identifier><identifier>DOI: 10.3851/IMP2460</identifier><identifier>PMID: 23221168</identifier><language>eng</language><publisher>London: International Medical Press</publisher><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Biological and medical sciences ; Data processing ; Hepacivirus - genetics ; Hepacivirus - immunology ; Hepacivirus - pathogenicity ; Hepatitis C - diagnosis ; Hepatitis C - immunology ; Hepatitis C - virology ; Hepatitis C virus ; Human viral diseases ; Humans ; Immune response ; Infectious diseases ; Medical sciences ; Persistent infection ; Pharmacology. 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Reinfection with a second strain of HCV after clearance of an initial infection has been reported in several recent studies. Moreover, individuals with HCV infection may be at risk of HCV superinfection with a second strain of HCV even after the establishment of persistent infection and the development of an immunological response to the initial virus. In vivo and in vitro data regarding HCV reinfection and superinfection, including the clinical consequences of these phenomena and the impact they have on vaccines require consideration in future studies.</description><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Data processing</subject><subject>Hepacivirus - genetics</subject><subject>Hepacivirus - immunology</subject><subject>Hepacivirus - pathogenicity</subject><subject>Hepatitis C - diagnosis</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis C - virology</subject><subject>Hepatitis C virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immune response</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Persistent infection</subject><subject>Pharmacology. Drug treatments</subject><subject>Recombination, Genetic</subject><subject>Recurrence</subject><subject>Superinfection</subject><subject>Superinfection - diagnosis</subject><subject>Superinfection - immunology</subject><subject>Superinfection - virology</subject><subject>Vaccines</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>1359-6535</issn><issn>2040-2058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0E1Lw0AQxvFFFFur-A2kCKKX6OzsS2aPUnwpVPSgXsNmswuRNKm7zcFvb6WxXj0NAz-ew5-xUw7XghS_mT-9oNSwx8YIEjIERftszIUymVZCjdhRSh8ASAbgkI1QIHKuaczOH2fv09SvfKzb4N267tqpbatp9Lv_mB0E2yR_MtwJe7u_e509Zovnh_nsdpE5IeU6M3mJuacggJPSFHgpbeUUYSAjAHjgOgjvOJUVUamMqHyJRpEIOdeIlZiwq-3uKnafvU_rYlkn55vGtr7rU8GRFBiphfgHFbkCaRRu6OWWutilFH0oVrFe2vhVcCh-2hVDu408G0b7cumrnfuNtQEXA7DJ2SZE27o6_TlNyBVo8Q0QanJ-</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>BLACKARD, Jason T</creator><general>International Medical Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>2012</creationdate><title>HCV superinfection and reinfection</title><author>BLACKARD, Jason T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-97b27e8f3018568f1b4adc582f893001f16f3ec18bd88b593deb29583f71622d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Data processing</topic><topic>Hepacivirus - genetics</topic><topic>Hepacivirus - immunology</topic><topic>Hepacivirus - pathogenicity</topic><topic>Hepatitis C - diagnosis</topic><topic>Hepatitis C - immunology</topic><topic>Hepatitis C - virology</topic><topic>Hepatitis C virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immune response</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Persistent infection</topic><topic>Pharmacology. Drug treatments</topic><topic>Recombination, Genetic</topic><topic>Recurrence</topic><topic>Superinfection</topic><topic>Superinfection - diagnosis</topic><topic>Superinfection - immunology</topic><topic>Superinfection - virology</topic><topic>Vaccines</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BLACKARD, Jason T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Antiviral therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BLACKARD, Jason T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HCV superinfection and reinfection</atitle><jtitle>Antiviral therapy</jtitle><addtitle>Antivir Ther</addtitle><date>2012</date><risdate>2012</risdate><volume>17</volume><issue>7</issue><spage>1443</spage><epage>1448</epage><pages>1443-1448</pages><issn>1359-6535</issn><eissn>2040-2058</eissn><abstract>The majority of acute HCV infections progress to chronicity, implying that the immune response is unable to clear virus in most instances. Reinfection with a second strain of HCV after clearance of an initial infection has been reported in several recent studies. Moreover, individuals with HCV infection may be at risk of HCV superinfection with a second strain of HCV even after the establishment of persistent infection and the development of an immunological response to the initial virus. In vivo and in vitro data regarding HCV reinfection and superinfection, including the clinical consequences of these phenomena and the impact they have on vaccines require consideration in future studies.</abstract><cop>London</cop><pub>International Medical Press</pub><pmid>23221168</pmid><doi>10.3851/IMP2460</doi><tpages>6</tpages></addata></record> |
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| ispartof | Antiviral therapy, 2012, Vol.17 (7), p.1443-1448 |
| issn | 1359-6535 2040-2058 |
| language | eng |
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| source | MEDLINE; Sage Journals GOLD Open Access 2024; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Data processing Hepacivirus - genetics Hepacivirus - immunology Hepacivirus - pathogenicity Hepatitis C - diagnosis Hepatitis C - immunology Hepatitis C - virology Hepatitis C virus Human viral diseases Humans Immune response Infectious diseases Medical sciences Persistent infection Pharmacology. Drug treatments Recombination, Genetic Recurrence Superinfection Superinfection - diagnosis Superinfection - immunology Superinfection - virology Vaccines Viral diseases Viral hepatitis |
| title | HCV superinfection and reinfection |
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