Transplantation of a hydrogen bonding network from West Nile virus protease onto Dengue-2 protease improves catalytic efficiency and sheds light on substrate specificity

The two-component serine protease of flaviviruses such as Dengue virus (DENV) and West Nile virus (WNV) are attractive targets for inhibitor/therapeutic design. Peptide aldehyde inhibitors that bind to the covalently tethered two-component WNV protease (WNVpro) with 50% inhibitory concentration (IC5...

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Veröffentlicht in:	Protein engineering, design and selection design and selection, 2012-12, Vol.25 (12), p.843-850
Hauptverfasser:	Doan, Danny N.P., Li, Kun Quan, Basavannacharya, Chandrakala, Vasudevan, Subhash G., Madhusudhan, M.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites Catalysis Dengue virus Dengue Virus - enzymology Dengue Virus - genetics Dengue virus type 2 Flavivirus Hydrogen Bonding Kinetics Models, Molecular Protease Inhibitors - chemistry Protein Conformation Substrate Specificity Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - genetics West Nile virus West Nile virus - enzymology West Nile virus - genetics
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