Characterization of fluoroquinolone and cephalosporin resistance mechanisms in Enterobacteriaceae isolated in a Dutch teaching hospital reveals the presence of an Escherichia coli ST131 clone with a specific mutation in parE

To characterize the mechanisms of fluoroquinolone and cephalosporin resistance in Enterobacteriaceae from a Dutch teaching hospital in 2008. We sequenced gyrA, gyrB, parC and parE. The presence of plasmid-encoded genes qnrA, qnrB, qnrS, aac(6')-Ib, qepA, bla(TEM), bla(SHV,) bla(OXA), bla(CTX-M)...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2013-01, Vol.68 (1), p.40-45
Hauptverfasser:	Paltansing, S, Kraakman, M E M, Ras, J M C, Wessels, E, Bernards, A T
Format:	Artikel
Sprache:	eng
Schlagworte:	Cephalosporin Resistance - drug effects Cephalosporin Resistance - genetics Chromosomes Cloning, Molecular DNA Topoisomerase IV - chemistry DNA Topoisomerase IV - genetics E coli Enterobacter cloacae Enterobacteriaceae Enterobacteriaceae - drug effects Enterobacteriaceae - genetics Enterobacteriaceae - isolation & purification Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - isolation & purification Fluoroquinolones - pharmacology Hospitals, Teaching Humans Klebsiella pneumoniae Microbial Sensitivity Tests - methods Mutation Mutation - genetics Netherlands - epidemiology Plasmids Polymorphism Polymorphism, Single Nucleotide - genetics Teaching hospitals
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