Synthesis and evaluation of M. tuberculosissalicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site

Mycobacterium tuberculosissalicylate synthase (MbtI) catalyses the first committed step in the biosynthesis of mycobactin T, an iron-chelating siderophore essential for the virulence and survival of M. tuberculosis. Co-crystal structures of MbtI with members of a first generation inhibitor library r...

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Veröffentlicht in:	Organic & biomolecular chemistry 2012-11, Vol.10 (46), p.9223-9236
Hauptverfasser:	Manos-Turvey, Alexandra, Cergol, Katie M, Salam, Noeris K, Bulloch, Esther MM, Chi, Gamma, Pang, Angel, Britton, Warwick J, West, Nicholas P, Baker, Edward N, Lott, JShaun, Payne, Richard J
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Enzymes Esters Mycobacterium Plasticity Probes scaffolds Siderophores Survival Tuberculosis Virulence
Online-Zugang:	Volltext
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