The ciliopathy disease protein NPHP9 promotes nuclear delivery and activation of the oncogenic transcriptional regulator TAZ

Nephronophthisis (NPH) is a genetically heterogenous kidney disease and represents the most common genetic cause for end-stage renal disease in children. It is caused by the mutation of genes encoding for the nephrocystin proteins (NPHPs) which localize to primary cilia or centrosomes, classifying t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human molecular genetics 2012-12, Vol.21 (26), p.5528-5538
Hauptverfasser:	HABBIG, Sandra, BARTRAM, Malte P, REINHARDT, H. Christian, BURST, Volker, BENZING, Thomas, SCHERMER, Bernhard, SÄGMÜLLER, Josef G, GRIESSMANN, Anabel, FRANKE, Mareike, MÜLLER, Roman-Ulrich, SCHWARZ, Ricarda, HOEHNE, Martin, BERGMANN, Carsten, TESSMER, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 protein 14-3-3 Proteins - genetics 14-3-3 Proteins - metabolism Biological and medical sciences Breast cancer Cell Nucleus - metabolism Cell physiology Cell Proliferation Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Centrosome - metabolism Centrosomes Children Cilia Cilia - metabolism Cilia - pathology Data processing Down-Regulation End-stage renal disease Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genetics of eukaryotes. Biological and molecular evolution HEK293 Cells Humans Immunoprecipitation Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kidney diseases Kidney Diseases, Cystic - genetics Kidney Diseases, Cystic - pathology LAT protein Luciferases - metabolism Molecular and cellular biology Molecular genetics Mutation Nephronophthisis NIMA-Related Kinases Nuclear transport Phosphorylation Plasmids Protein Kinases - genetics Protein Kinases - metabolism Proteins - genetics Proteins - metabolism Signal Transduction Transcription Transcription. Transcription factor. Splicing. Rna processing Tumorigenesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!