Lung cancer in patients with HIV Infection and review of the literature
The improved survival of patients since the use of highly active antiretroviral treatments has lead to the reporting of non-AIDS defining tumors, such as lung cancer. Analysis of the records of 22 HIV-infected patients with lung cancer (LC) diagnosed in three hospitals located in the Paris area (Fra...
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| Veröffentlicht in: | Medical oncology (Northwood, London, England) London, England), 2004-01, Vol.21 (2), p.109-116 |
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| creator | Spano, Jean-Philippe Massiani, Marie-Ange Bentata, Michele Rixe, Olivier Friard, Sylvie Bossi, Philippe Rouges, François Katlama, Christine Breau, Jean-Luc Morere, Jean-Francois Khayat, David Couderc, Louis-Jean |
| description | The improved survival of patients since the use of highly active antiretroviral treatments has lead to the reporting of non-AIDS defining tumors, such as lung cancer.
Analysis of the records of 22 HIV-infected patients with lung cancer (LC) diagnosed in three hospitals located in the Paris area (France).
Twenty-one patients were smokers. The patients (86% male, 14% female) had a median age of 45 yr (range, 33-64 yr). Risk factors for HIV infection were intravenous drug use in 5 patients, homosexual transmission in 10 patients, and heterosexual transmission in 7 patients. At diagnosis of LC, seven patients had previously developed a CDC-defined AIDS manifestation, the median CD4 cell count was 364/mm3 (range 20-854/mm3) and median HIV1 RNA viral load was 3000 copies/mL. The most frequent histological subtype was squamous cell carcinoma (11 cases). A stage III-IV disease was observed in 75% of the patients. Only one patient had a small-cell lung carcinoma. Twenty-one patients received combined specific therapy, of which six patients underwent surgery for the LC. The median overall survival was 7 mo. No opportunistic infections occurred during LC therapy.
LC occurs at a young age in HIV-infected smokers. LC is not associated with severe immunodeficiency. The prognosis is poor because of their initial extensive disease and a poor response to therapy. However, surgery appears to improve outcome in much the same way as in the general population. |
| doi_str_mv | 10.1385/MO:21:2:109 |
| format | Article |
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Analysis of the records of 22 HIV-infected patients with lung cancer (LC) diagnosed in three hospitals located in the Paris area (France).
Twenty-one patients were smokers. The patients (86% male, 14% female) had a median age of 45 yr (range, 33-64 yr). Risk factors for HIV infection were intravenous drug use in 5 patients, homosexual transmission in 10 patients, and heterosexual transmission in 7 patients. At diagnosis of LC, seven patients had previously developed a CDC-defined AIDS manifestation, the median CD4 cell count was 364/mm3 (range 20-854/mm3) and median HIV1 RNA viral load was 3000 copies/mL. The most frequent histological subtype was squamous cell carcinoma (11 cases). A stage III-IV disease was observed in 75% of the patients. Only one patient had a small-cell lung carcinoma. Twenty-one patients received combined specific therapy, of which six patients underwent surgery for the LC. The median overall survival was 7 mo. No opportunistic infections occurred during LC therapy.
LC occurs at a young age in HIV-infected smokers. LC is not associated with severe immunodeficiency. The prognosis is poor because of their initial extensive disease and a poor response to therapy. However, surgery appears to improve outcome in much the same way as in the general population.</description><identifier>ISSN: 1357-0560</identifier><identifier>EISSN: 1357-0560</identifier><identifier>EISSN: 1559-131X</identifier><identifier>DOI: 10.1385/MO:21:2:109</identifier><identifier>PMID: 15299182</identifier><identifier>CODEN: MONCEZ</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Acquired immune deficiency syndrome ; Adult ; Age ; Age of Onset ; Antiviral agents ; CD4 antigen ; Disease transmission ; Female ; HIV Infections - complications ; Hospitals ; Human immunodeficiency virus 1 ; Humans ; Immunodeficiency ; Intravenous administration ; Literature reviews ; Lung cancer ; Lung carcinoma ; Lung Neoplasms - etiology ; Lung Neoplasms - pathology ; Male ; Middle Aged ; Oncology ; Opportunist infection ; Prognosis ; Retrospective Studies ; Risk Factors ; RNA ; Smoking - adverse effects ; squamous cell carcinoma ; Substance-Related Disorders ; Surgery ; Survival ; Tumors</subject><ispartof>Medical oncology (Northwood, London, England), 2004-01, Vol.21 (2), p.109-116</ispartof><rights>Humana Press Inc. 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-6ddd64cad91c3033c46fb372093a03f00088920c917ed8dccd86f29a672e85673</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15299182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spano, Jean-Philippe</creatorcontrib><creatorcontrib>Massiani, Marie-Ange</creatorcontrib><creatorcontrib>Bentata, Michele</creatorcontrib><creatorcontrib>Rixe, Olivier</creatorcontrib><creatorcontrib>Friard, Sylvie</creatorcontrib><creatorcontrib>Bossi, Philippe</creatorcontrib><creatorcontrib>Rouges, François</creatorcontrib><creatorcontrib>Katlama, Christine</creatorcontrib><creatorcontrib>Breau, Jean-Luc</creatorcontrib><creatorcontrib>Morere, Jean-Francois</creatorcontrib><creatorcontrib>Khayat, David</creatorcontrib><creatorcontrib>Couderc, Louis-Jean</creatorcontrib><title>Lung cancer in patients with HIV Infection and review of the literature</title><title>Medical oncology (Northwood, London, England)</title><addtitle>Med Oncol</addtitle><description>The improved survival of patients since the use of highly active antiretroviral treatments has lead to the reporting of non-AIDS defining tumors, such as lung cancer.
Analysis of the records of 22 HIV-infected patients with lung cancer (LC) diagnosed in three hospitals located in the Paris area (France).
Twenty-one patients were smokers. The patients (86% male, 14% female) had a median age of 45 yr (range, 33-64 yr). Risk factors for HIV infection were intravenous drug use in 5 patients, homosexual transmission in 10 patients, and heterosexual transmission in 7 patients. At diagnosis of LC, seven patients had previously developed a CDC-defined AIDS manifestation, the median CD4 cell count was 364/mm3 (range 20-854/mm3) and median HIV1 RNA viral load was 3000 copies/mL. The most frequent histological subtype was squamous cell carcinoma (11 cases). A stage III-IV disease was observed in 75% of the patients. Only one patient had a small-cell lung carcinoma. Twenty-one patients received combined specific therapy, of which six patients underwent surgery for the LC. The median overall survival was 7 mo. No opportunistic infections occurred during LC therapy.
LC occurs at a young age in HIV-infected smokers. LC is not associated with severe immunodeficiency. The prognosis is poor because of their initial extensive disease and a poor response to therapy. However, surgery appears to improve outcome in much the same way as in the general population.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adult</subject><subject>Age</subject><subject>Age of Onset</subject><subject>Antiviral agents</subject><subject>CD4 antigen</subject><subject>Disease transmission</subject><subject>Female</subject><subject>HIV Infections - complications</subject><subject>Hospitals</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Immunodeficiency</subject><subject>Intravenous administration</subject><subject>Literature reviews</subject><subject>Lung cancer</subject><subject>Lung carcinoma</subject><subject>Lung Neoplasms - etiology</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Opportunist infection</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>RNA</subject><subject>Smoking - adverse effects</subject><subject>squamous cell carcinoma</subject><subject>Substance-Related Disorders</subject><subject>Surgery</subject><subject>Survival</subject><subject>Tumors</subject><issn>1357-0560</issn><issn>1357-0560</issn><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkE1LAzEYhIMotlZP3iV4EqSaj2aT9CZF20JLL-o1pEnWpmyzNcla_PduaUHxNO_Aw_DOAHCN0QOmgj3OF0OCh2SIkTwBXUwZ7yNWoNM_dwdcpLRGiGBG5Dno7EViQbpgPGvCBzQ6GBehD3Crs3chJ7jzeQUn03c4DaUz2dcB6mBhdF_e7WBdwrxysPLZRZ2b6C7BWamr5K6O2gNvL8-vo0l_thhPR0-zvqEDlvuFtbYYGG0lNhRRagZFuaScIEk1oiVCSAhJkJGYOyusMVYUJZG64MQJVnDaA3eH3G2sPxuXstr4ZFxV6eDqJilMBEOCt6Vb9PYfuq6bGNrvlOCMcUoEaaH7A2RinVJ0pdpGv9HxW2Gk9vOq-UIRrEjrZUvfHCOb5cbZX_a4J_0BorZy_Q</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Spano, Jean-Philippe</creator><creator>Massiani, Marie-Ange</creator><creator>Bentata, Michele</creator><creator>Rixe, Olivier</creator><creator>Friard, Sylvie</creator><creator>Bossi, Philippe</creator><creator>Rouges, François</creator><creator>Katlama, Christine</creator><creator>Breau, Jean-Luc</creator><creator>Morere, Jean-Francois</creator><creator>Khayat, David</creator><creator>Couderc, Louis-Jean</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20040101</creationdate><title>Lung cancer in patients with HIV Infection and review of the literature</title><author>Spano, Jean-Philippe ; Massiani, Marie-Ange ; Bentata, Michele ; Rixe, Olivier ; Friard, Sylvie ; Bossi, Philippe ; Rouges, François ; Katlama, Christine ; Breau, Jean-Luc ; Morere, Jean-Francois ; Khayat, David ; Couderc, Louis-Jean</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-6ddd64cad91c3033c46fb372093a03f00088920c917ed8dccd86f29a672e85673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Adult</topic><topic>Age</topic><topic>Age of Onset</topic><topic>Antiviral agents</topic><topic>CD4 antigen</topic><topic>Disease transmission</topic><topic>Female</topic><topic>HIV Infections - complications</topic><topic>Hospitals</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Immunodeficiency</topic><topic>Intravenous administration</topic><topic>Literature reviews</topic><topic>Lung cancer</topic><topic>Lung carcinoma</topic><topic>Lung Neoplasms - etiology</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Opportunist infection</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>RNA</topic><topic>Smoking - adverse effects</topic><topic>squamous cell carcinoma</topic><topic>Substance-Related Disorders</topic><topic>Surgery</topic><topic>Survival</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spano, Jean-Philippe</creatorcontrib><creatorcontrib>Massiani, Marie-Ange</creatorcontrib><creatorcontrib>Bentata, Michele</creatorcontrib><creatorcontrib>Rixe, Olivier</creatorcontrib><creatorcontrib>Friard, Sylvie</creatorcontrib><creatorcontrib>Bossi, Philippe</creatorcontrib><creatorcontrib>Rouges, François</creatorcontrib><creatorcontrib>Katlama, Christine</creatorcontrib><creatorcontrib>Breau, Jean-Luc</creatorcontrib><creatorcontrib>Morere, Jean-Francois</creatorcontrib><creatorcontrib>Khayat, David</creatorcontrib><creatorcontrib>Couderc, Louis-Jean</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Medical oncology (Northwood, London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spano, Jean-Philippe</au><au>Massiani, Marie-Ange</au><au>Bentata, Michele</au><au>Rixe, Olivier</au><au>Friard, Sylvie</au><au>Bossi, Philippe</au><au>Rouges, François</au><au>Katlama, Christine</au><au>Breau, Jean-Luc</au><au>Morere, Jean-Francois</au><au>Khayat, David</au><au>Couderc, Louis-Jean</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lung cancer in patients with HIV Infection and review of the literature</atitle><jtitle>Medical oncology (Northwood, London, England)</jtitle><addtitle>Med Oncol</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>21</volume><issue>2</issue><spage>109</spage><epage>116</epage><pages>109-116</pages><issn>1357-0560</issn><eissn>1357-0560</eissn><eissn>1559-131X</eissn><coden>MONCEZ</coden><abstract>The improved survival of patients since the use of highly active antiretroviral treatments has lead to the reporting of non-AIDS defining tumors, such as lung cancer.
Analysis of the records of 22 HIV-infected patients with lung cancer (LC) diagnosed in three hospitals located in the Paris area (France).
Twenty-one patients were smokers. The patients (86% male, 14% female) had a median age of 45 yr (range, 33-64 yr). Risk factors for HIV infection were intravenous drug use in 5 patients, homosexual transmission in 10 patients, and heterosexual transmission in 7 patients. At diagnosis of LC, seven patients had previously developed a CDC-defined AIDS manifestation, the median CD4 cell count was 364/mm3 (range 20-854/mm3) and median HIV1 RNA viral load was 3000 copies/mL. The most frequent histological subtype was squamous cell carcinoma (11 cases). A stage III-IV disease was observed in 75% of the patients. Only one patient had a small-cell lung carcinoma. Twenty-one patients received combined specific therapy, of which six patients underwent surgery for the LC. The median overall survival was 7 mo. No opportunistic infections occurred during LC therapy.
LC occurs at a young age in HIV-infected smokers. LC is not associated with severe immunodeficiency. The prognosis is poor because of their initial extensive disease and a poor response to therapy. However, surgery appears to improve outcome in much the same way as in the general population.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>15299182</pmid><doi>10.1385/MO:21:2:109</doi><tpages>8</tpages></addata></record> |
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| subjects | Acquired immune deficiency syndrome Adult Age Age of Onset Antiviral agents CD4 antigen Disease transmission Female HIV Infections - complications Hospitals Human immunodeficiency virus 1 Humans Immunodeficiency Intravenous administration Literature reviews Lung cancer Lung carcinoma Lung Neoplasms - etiology Lung Neoplasms - pathology Male Middle Aged Oncology Opportunist infection Prognosis Retrospective Studies Risk Factors RNA Smoking - adverse effects squamous cell carcinoma Substance-Related Disorders Surgery Survival Tumors |
| title | Lung cancer in patients with HIV Infection and review of the literature |
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