Exact and approximate distributions of protein and mRNA levels in the low-copy regime of gene expression

Gene expression at the single-cell level incorporates reaction mechanisms which are intrinsically stochastic as they involve molecular species present at low copy numbers. The dynamics of these mechanisms can be described quantitatively using stochastic master-equation modelling; in this paper we st...

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Veröffentlicht in:	Journal of mathematical biology 2012-04, Vol.64 (5), p.829-854
Hauptverfasser:	Bokes, Pavol, King, John R., Wood, Andrew T. A., Loose, Matthew
Format:	Artikel
Sprache:	eng
Schlagworte:	Applications of Mathematics Gene Dosage Mathematical and Computational Biology Mathematics Mathematics and Statistics Models, Genetic Protein Biosynthesis - genetics Proteins - genetics Proteins - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Stochastic Processes Transcription, Genetic
Online-Zugang:	Volltext
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