Emerging role for RNA-based regulation in plant immunity
Infection by phytopathogenic bacteria triggers massive changes in plant gene expression, which are thought to be mostly a result of transcriptional reprogramming. However, evidence is accumulating that plants additionally use post-transcriptional regulation of immune-responsive mRNAs as a strategic...
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| Veröffentlicht in: | The New phytologist 2013-01, Vol.197 (2), p.394-404 |
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| container_title | The New phytologist |
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| creator | Staiger, Dorothee Korneli, Christin Lummer, Martina Navarro, Lionel |
| description | Infection by phytopathogenic bacteria triggers massive changes in plant gene expression, which are thought to be mostly a result of transcriptional reprogramming. However, evidence is accumulating that plants additionally use post-transcriptional regulation of immune-responsive mRNAs as a strategic weapon to shape the defense-related transcriptome. Cellular RNA-binding proteins regulate RNA stability, splicing or mRNA export of immune-response transcripts. In particular, mutants defective in alternative splicing of resistance genes exhibit compromised disease resistance. Furthermore, detection of bacterial pathogens induces the differential expression of small non-coding RNAs including microRNAs that impact the host defense transcriptome. Phytopathogenic bacteria in turn have evolved effector proteins to inhibit biogenesis and/or activity of cellular microRNAs. Whereas RNA silencing has long been known as an antiviral defense response, recent findings also reveal a major role of this process in antibacterial defense. Here we review the function of RNA-binding proteins and small RNA-directed post-transcriptional regulation in antibacterial defense. We mainly focus on studies that used the model system Arabidopsis thaliana and also discuss selected examples from other plants. |
| doi_str_mv | 10.1111/nph.12022 |
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However, evidence is accumulating that plants additionally use post-transcriptional regulation of immune-responsive mRNAs as a strategic weapon to shape the defense-related transcriptome. Cellular RNA-binding proteins regulate RNA stability, splicing or mRNA export of immune-response transcripts. In particular, mutants defective in alternative splicing of resistance genes exhibit compromised disease resistance. Furthermore, detection of bacterial pathogens induces the differential expression of small non-coding RNAs including microRNAs that impact the host defense transcriptome. Phytopathogenic bacteria in turn have evolved effector proteins to inhibit biogenesis and/or activity of cellular microRNAs. Whereas RNA silencing has long been known as an antiviral defense response, recent findings also reveal a major role of this process in antibacterial defense. Here we review the function of RNA-binding proteins and small RNA-directed post-transcriptional regulation in antibacterial defense. We mainly focus on studies that used the model system Arabidopsis thaliana and also discuss selected examples from other plants.</description><identifier>ISSN: 0028-646X</identifier><identifier>EISSN: 1469-8137</identifier><identifier>DOI: 10.1111/nph.12022</identifier><identifier>PMID: 23163405</identifier><language>eng</language><publisher>England: New Phytologist Trust</publisher><subject>Alternative splicing ; Antibiotics ; Antiinfectives and antibacterials ; Antiviral agents ; Arabidopsis thaliana ; Bacteria ; Binding ; Biogenesis ; Defense ; Disease resistance ; Gene expression ; Gene expression regulation ; Gene regulation ; Gene Silencing ; Genes ; Immune response ; Immunity ; Messenger RNA ; MicroRNA ; MicroRNAs ; miRNA ; mRNA stability ; Non-coding RNA ; Nucleic acids ; Pathogens ; Plant bacterial diseases ; Plant immunity ; Plant Immunity - immunology ; post‐transcriptional ; Proteins ; Ribonucleic acid ; RNA ; RNA Splicing - genetics ; RNA Stability - genetics ; RNA, Plant - metabolism ; RNA-Binding Proteins - metabolism ; RNA-mediated interference ; RNA‐binding protein ; siRNA ; Small interfering RNA ; Splicing ; Tansley reviews ; Transcription ; Transcriptomes</subject><ispartof>The New phytologist, 2013-01, Vol.197 (2), p.394-404</ispartof><rights>2013 New Phytologist Trust</rights><rights>2012 The Authors. New Phytologist © 2012 New Phytologist Trust</rights><rights>2012 The Authors. New Phytologist © 2012 New Phytologist Trust.</rights><rights>Copyright © 2013 New Phytologist Trust</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5532-edc7bf0de6ad3fac5c393cba586f62e984bea7079c90f73e68edae758201fb493</citedby><cites>FETCH-LOGICAL-c5532-edc7bf0de6ad3fac5c393cba586f62e984bea7079c90f73e68edae758201fb493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/newphytologist.197.2.394$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/newphytologist.197.2.394$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,1417,1433,27924,27925,45574,45575,46409,46833,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23163405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Staiger, Dorothee</creatorcontrib><creatorcontrib>Korneli, Christin</creatorcontrib><creatorcontrib>Lummer, Martina</creatorcontrib><creatorcontrib>Navarro, Lionel</creatorcontrib><title>Emerging role for RNA-based regulation in plant immunity</title><title>The New phytologist</title><addtitle>New Phytol</addtitle><description>Infection by phytopathogenic bacteria triggers massive changes in plant gene expression, which are thought to be mostly a result of transcriptional reprogramming. However, evidence is accumulating that plants additionally use post-transcriptional regulation of immune-responsive mRNAs as a strategic weapon to shape the defense-related transcriptome. Cellular RNA-binding proteins regulate RNA stability, splicing or mRNA export of immune-response transcripts. In particular, mutants defective in alternative splicing of resistance genes exhibit compromised disease resistance. Furthermore, detection of bacterial pathogens induces the differential expression of small non-coding RNAs including microRNAs that impact the host defense transcriptome. Phytopathogenic bacteria in turn have evolved effector proteins to inhibit biogenesis and/or activity of cellular microRNAs. Whereas RNA silencing has long been known as an antiviral defense response, recent findings also reveal a major role of this process in antibacterial defense. Here we review the function of RNA-binding proteins and small RNA-directed post-transcriptional regulation in antibacterial defense. We mainly focus on studies that used the model system Arabidopsis thaliana and also discuss selected examples from other plants.</description><subject>Alternative splicing</subject><subject>Antibiotics</subject><subject>Antiinfectives and antibacterials</subject><subject>Antiviral agents</subject><subject>Arabidopsis thaliana</subject><subject>Bacteria</subject><subject>Binding</subject><subject>Biogenesis</subject><subject>Defense</subject><subject>Disease resistance</subject><subject>Gene expression</subject><subject>Gene expression regulation</subject><subject>Gene regulation</subject><subject>Gene Silencing</subject><subject>Genes</subject><subject>Immune response</subject><subject>Immunity</subject><subject>Messenger RNA</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>miRNA</subject><subject>mRNA stability</subject><subject>Non-coding RNA</subject><subject>Nucleic acids</subject><subject>Pathogens</subject><subject>Plant bacterial diseases</subject><subject>Plant immunity</subject><subject>Plant Immunity - immunology</subject><subject>post‐transcriptional</subject><subject>Proteins</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA Splicing - genetics</subject><subject>RNA Stability - genetics</subject><subject>RNA, Plant - metabolism</subject><subject>RNA-Binding Proteins - metabolism</subject><subject>RNA-mediated interference</subject><subject>RNA‐binding protein</subject><subject>siRNA</subject><subject>Small interfering RNA</subject><subject>Splicing</subject><subject>Tansley reviews</subject><subject>Transcription</subject><subject>Transcriptomes</subject><issn>0028-646X</issn><issn>1469-8137</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0c1q3DAUBWBRWprppIu-QDF0kyycSLrW3zKENCmEtJQGuhOyfT3RYFuuZBPm7at0kiwKKdVGm-8ernQI-cDoCcvndJzuThinnL8iK1ZJU2oG6jVZUcp1KSv584C8S2lLKTVC8rfkgAOTUFGxIvpiwLjx46aIoceiC7H4fnNW1i5hW0TcLL2bfRgLPxZT78a58MOwjH7eHZI3nesTvn-81-T288WP86vy-uvll_Oz67IRAniJbaPqjrYoXQuda0QDBpraCS07ydHoqkanqDKNoZ0ClBpbh0poTllXVwbW5GifO8Xwa8E028GnBvu8DIYlWca1oFpKUP9BFXBFacZr8ukvug1LHPNDLBcMQBmjzb8UqyB_ooGM1-R4r5oYUorY2Sn6wcWdZdQ-9GNzP_ZPP9l-fExc6gHbZ_lUSAane3Dve9y9nGRvvl09RZb7iW2aQ3yeGPF-utvNoQ8bnxdnRlluwVTwGzfgp3w</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Staiger, Dorothee</creator><creator>Korneli, Christin</creator><creator>Lummer, Martina</creator><creator>Navarro, Lionel</creator><general>New Phytologist Trust</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SN</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7TM</scope></search><sort><creationdate>201301</creationdate><title>Emerging role for RNA-based regulation in plant immunity</title><author>Staiger, Dorothee ; 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| subjects | Alternative splicing Antibiotics Antiinfectives and antibacterials Antiviral agents Arabidopsis thaliana Bacteria Binding Biogenesis Defense Disease resistance Gene expression Gene expression regulation Gene regulation Gene Silencing Genes Immune response Immunity Messenger RNA MicroRNA MicroRNAs miRNA mRNA stability Non-coding RNA Nucleic acids Pathogens Plant bacterial diseases Plant immunity Plant Immunity - immunology post‐transcriptional Proteins Ribonucleic acid RNA RNA Splicing - genetics RNA Stability - genetics RNA, Plant - metabolism RNA-Binding Proteins - metabolism RNA-mediated interference RNA‐binding protein siRNA Small interfering RNA Splicing Tansley reviews Transcription Transcriptomes |
| title | Emerging role for RNA-based regulation in plant immunity |
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