Congruence of vascular network remodeling and neuronal dispersion in the hippocampus of reelin-deficient mice
In the hippocampus, neurons and fiber projections are strictly organized in layers and supplied with oxygen via a vascular network that also develops layer-specific characteristics in wild-type mice, as shown in the present study for the first time in a quantitative manner. By contrast, in the reele...
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| description | In the hippocampus, neurons and fiber projections are strictly organized in layers and supplied with oxygen via a vascular network that also develops layer-specific characteristics in wild-type mice, as shown in the present study for the first time in a quantitative manner. By contrast, in the reeler mutant, well known for its neuronal migration defects due to the lack of the extracellular matrix protein reelin, emerging layer-specific characteristics of the vascular pattern were found to be remodeled during development of the dentate gyrus. Remarkably, in the first postnatal week, when a granule cell layer was still discernable in the reeler dentate gyrus, also the reeler vascular pattern resembled wild type. Thus, at postnatal day 6, unbranched microvessels traversed the granule cell layer and bifurcated when reaching the subgranular zone. Only after the first postnatal week vascular network remodeling in the reeler dentate gyrus became apparent, when the proportion of dispersed granule cells increased. Hence, vessel bifurcation frequency decreased in the maturing reeler dentate gyrus, but increased in wild type, resulting in significant differences (approx. 100%;
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| doi_str_mv | 10.1007/s00418-012-0912-9 |
| format | Article |
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p
< 0.01) between adult wild type and reeler. Moreover, layer-specific vessel bifurcation frequencies disappeared in the maturing reeler dentate gyrus. Finally, a wild type-like vascular pattern was also found in the dentate gyrus of mice deficient for the reelin receptor
very low density lipoprotein receptor
(VLDLR), precluding a requirement of VLDLR for normal vascular pattern formation in the dentate gyrus. In sum, our findings show that vascular network remodeling in the reeler dentate gyrus is closely linked to the progression of granule cell dispersion.</description><identifier>ISSN: 0948-6143</identifier><identifier>EISSN: 1432-119X</identifier><identifier>DOI: 10.1007/s00418-012-0912-9</identifier><identifier>PMID: 22261923</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Cell Adhesion Molecules, Neuronal - deficiency ; Cell Adhesion Molecules, Neuronal - metabolism ; Cell Biology ; Cell migration ; Dentate gyrus ; Dentate Gyrus - blood supply ; Dentate Gyrus - cytology ; Dentate Gyrus - metabolism ; Developmental Biology ; Extracellular matrix ; Extracellular Matrix Proteins - deficiency ; Extracellular Matrix Proteins - metabolism ; Female ; Fibers ; Granule cells ; Hippocampus ; Lipoprotein (low density) receptors ; Male ; Mice ; Mice, Inbred Strains ; Mice, Knockout ; Models, Neurological ; Motor task performance ; Nerve Tissue Proteins - deficiency ; Nerve Tissue Proteins - metabolism ; Neurons ; Neurons - metabolism ; Original Paper ; Oxygen ; Pattern formation ; Reelin protein ; Rodents ; Serine Endopeptidases - deficiency ; Serine Endopeptidases - metabolism ; Vascular endothelial growth factor</subject><ispartof>Histochemistry and cell biology, 2012-05, Vol.137 (5), p.629-639</ispartof><rights>Springer-Verlag 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-75a94ccc99ace304e54f720bd16be809aa05f623ee6c968b9315960272df75e83</citedby><cites>FETCH-LOGICAL-c405t-75a94ccc99ace304e54f720bd16be809aa05f623ee6c968b9315960272df75e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00418-012-0912-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00418-012-0912-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22261923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lindhorst, Tina</creatorcontrib><creatorcontrib>Kurz, Haymo</creatorcontrib><creatorcontrib>Sibbe, Mirjam</creatorcontrib><creatorcontrib>Meseke, Maurice</creatorcontrib><creatorcontrib>Förster, Eckart</creatorcontrib><title>Congruence of vascular network remodeling and neuronal dispersion in the hippocampus of reelin-deficient mice</title><title>Histochemistry and cell biology</title><addtitle>Histochem Cell Biol</addtitle><addtitle>Histochem Cell Biol</addtitle><description>In the hippocampus, neurons and fiber projections are strictly organized in layers and supplied with oxygen via a vascular network that also develops layer-specific characteristics in wild-type mice, as shown in the present study for the first time in a quantitative manner. By contrast, in the reeler mutant, well known for its neuronal migration defects due to the lack of the extracellular matrix protein reelin, emerging layer-specific characteristics of the vascular pattern were found to be remodeled during development of the dentate gyrus. Remarkably, in the first postnatal week, when a granule cell layer was still discernable in the reeler dentate gyrus, also the reeler vascular pattern resembled wild type. Thus, at postnatal day 6, unbranched microvessels traversed the granule cell layer and bifurcated when reaching the subgranular zone. Only after the first postnatal week vascular network remodeling in the reeler dentate gyrus became apparent, when the proportion of dispersed granule cells increased. Hence, vessel bifurcation frequency decreased in the maturing reeler dentate gyrus, but increased in wild type, resulting in significant differences (approx. 100%;
p
< 0.01) between adult wild type and reeler. Moreover, layer-specific vessel bifurcation frequencies disappeared in the maturing reeler dentate gyrus. Finally, a wild type-like vascular pattern was also found in the dentate gyrus of mice deficient for the reelin receptor
very low density lipoprotein receptor
(VLDLR), precluding a requirement of VLDLR for normal vascular pattern formation in the dentate gyrus. In sum, our findings show that vascular network remodeling in the reeler dentate gyrus is closely linked to the progression of granule cell dispersion.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Cell Adhesion Molecules, Neuronal - deficiency</subject><subject>Cell Adhesion Molecules, Neuronal - metabolism</subject><subject>Cell Biology</subject><subject>Cell migration</subject><subject>Dentate gyrus</subject><subject>Dentate Gyrus - blood supply</subject><subject>Dentate Gyrus - cytology</subject><subject>Dentate Gyrus - metabolism</subject><subject>Developmental Biology</subject><subject>Extracellular matrix</subject><subject>Extracellular Matrix Proteins - deficiency</subject><subject>Extracellular Matrix Proteins - metabolism</subject><subject>Female</subject><subject>Fibers</subject><subject>Granule cells</subject><subject>Hippocampus</subject><subject>Lipoprotein (low density) receptors</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Mice, Knockout</subject><subject>Models, Neurological</subject><subject>Motor task performance</subject><subject>Nerve Tissue Proteins - deficiency</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Neurons</subject><subject>Neurons - metabolism</subject><subject>Original Paper</subject><subject>Oxygen</subject><subject>Pattern formation</subject><subject>Reelin protein</subject><subject>Rodents</subject><subject>Serine Endopeptidases - deficiency</subject><subject>Serine Endopeptidases - metabolism</subject><subject>Vascular endothelial growth factor</subject><issn>0948-6143</issn><issn>1432-119X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkVFL3TAYhsNQ5tHtB-xGAt54U_2SNm2_SznoJgi72WB3JSf9eoy2SU3ayf79Us6ZyEC8SeDL8z4heRn7IuBCAFSXEaAQdQZCZoBpwQ9sJYpcZkLgrwO2AizqrEyTI3Yc4wOAUCjlR3YkpSwFynzFhrV32zCTM8R9x3_raOZeB-5oevbhkQcafEu9dVuuXZvGc_BO97y1caQQrXfcOj7dE7-34-iNHsY5LqZASyprqbPGkpv4YA19Yoed7iN93u8n7OfN9Y_1t-zu-9fb9dVdZgpQU1YpjYUxBlEbyqEgVXSVhE0ryg3VgFqD6kqZE5UGy3qDeXpYCbKSbVcpqvMTdr7zjsE_zRSnZrDRUN9rR36OjZC1glohivdRAFQCE5_Qs__QBz-H9BsLJWRV5rXARIkdZYKPMVDXjMEOOvxJ0GKrml1tTYo0S23Nkjndm-fNQO1L4l9PCZA7IKYjt6Xw-uq3rH8B70WiwQ</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Lindhorst, Tina</creator><creator>Kurz, Haymo</creator><creator>Sibbe, Mirjam</creator><creator>Meseke, Maurice</creator><creator>Förster, Eckart</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>Congruence of vascular network remodeling and neuronal dispersion in the hippocampus of reelin-deficient mice</title><author>Lindhorst, Tina ; Kurz, Haymo ; Sibbe, Mirjam ; Meseke, Maurice ; Förster, Eckart</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-75a94ccc99ace304e54f720bd16be809aa05f623ee6c968b9315960272df75e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Cell Adhesion Molecules, Neuronal - deficiency</topic><topic>Cell Adhesion Molecules, Neuronal - metabolism</topic><topic>Cell Biology</topic><topic>Cell migration</topic><topic>Dentate gyrus</topic><topic>Dentate Gyrus - blood supply</topic><topic>Dentate Gyrus - cytology</topic><topic>Dentate Gyrus - metabolism</topic><topic>Developmental Biology</topic><topic>Extracellular matrix</topic><topic>Extracellular Matrix Proteins - deficiency</topic><topic>Extracellular Matrix Proteins - metabolism</topic><topic>Female</topic><topic>Fibers</topic><topic>Granule cells</topic><topic>Hippocampus</topic><topic>Lipoprotein (low density) receptors</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Mice, Knockout</topic><topic>Models, Neurological</topic><topic>Motor task performance</topic><topic>Nerve Tissue Proteins - deficiency</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Neurons</topic><topic>Neurons - metabolism</topic><topic>Original Paper</topic><topic>Oxygen</topic><topic>Pattern formation</topic><topic>Reelin protein</topic><topic>Rodents</topic><topic>Serine Endopeptidases - 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Academic</collection><jtitle>Histochemistry and cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lindhorst, Tina</au><au>Kurz, Haymo</au><au>Sibbe, Mirjam</au><au>Meseke, Maurice</au><au>Förster, Eckart</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Congruence of vascular network remodeling and neuronal dispersion in the hippocampus of reelin-deficient mice</atitle><jtitle>Histochemistry and cell biology</jtitle><stitle>Histochem Cell Biol</stitle><addtitle>Histochem Cell Biol</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>137</volume><issue>5</issue><spage>629</spage><epage>639</epage><pages>629-639</pages><issn>0948-6143</issn><eissn>1432-119X</eissn><abstract>In the hippocampus, neurons and fiber projections are strictly organized in layers and supplied with oxygen via a vascular network that also develops layer-specific characteristics in wild-type mice, as shown in the present study for the first time in a quantitative manner. By contrast, in the reeler mutant, well known for its neuronal migration defects due to the lack of the extracellular matrix protein reelin, emerging layer-specific characteristics of the vascular pattern were found to be remodeled during development of the dentate gyrus. Remarkably, in the first postnatal week, when a granule cell layer was still discernable in the reeler dentate gyrus, also the reeler vascular pattern resembled wild type. Thus, at postnatal day 6, unbranched microvessels traversed the granule cell layer and bifurcated when reaching the subgranular zone. Only after the first postnatal week vascular network remodeling in the reeler dentate gyrus became apparent, when the proportion of dispersed granule cells increased. Hence, vessel bifurcation frequency decreased in the maturing reeler dentate gyrus, but increased in wild type, resulting in significant differences (approx. 100%;
p
< 0.01) between adult wild type and reeler. Moreover, layer-specific vessel bifurcation frequencies disappeared in the maturing reeler dentate gyrus. Finally, a wild type-like vascular pattern was also found in the dentate gyrus of mice deficient for the reelin receptor
very low density lipoprotein receptor
(VLDLR), precluding a requirement of VLDLR for normal vascular pattern formation in the dentate gyrus. In sum, our findings show that vascular network remodeling in the reeler dentate gyrus is closely linked to the progression of granule cell dispersion.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22261923</pmid><doi>10.1007/s00418-012-0912-9</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Biochemistry Biomedical and Life Sciences Biomedicine Brain Cell Adhesion Molecules, Neuronal - deficiency Cell Adhesion Molecules, Neuronal - metabolism Cell Biology Cell migration Dentate gyrus Dentate Gyrus - blood supply Dentate Gyrus - cytology Dentate Gyrus - metabolism Developmental Biology Extracellular matrix Extracellular Matrix Proteins - deficiency Extracellular Matrix Proteins - metabolism Female Fibers Granule cells Hippocampus Lipoprotein (low density) receptors Male Mice Mice, Inbred Strains Mice, Knockout Models, Neurological Motor task performance Nerve Tissue Proteins - deficiency Nerve Tissue Proteins - metabolism Neurons Neurons - metabolism Original Paper Oxygen Pattern formation Reelin protein Rodents Serine Endopeptidases - deficiency Serine Endopeptidases - metabolism Vascular endothelial growth factor |
| title | Congruence of vascular network remodeling and neuronal dispersion in the hippocampus of reelin-deficient mice |
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