Langerhans Cells, Antigen Presentation, and the Diversity of Responses to Chemical Allergens
Respiratory and contact chemical allergens provoke differential immune responses in mice, stimulating preferentially T helper-2 (TH2) and TH1 cells, respectively. In an attempt to discover whether such differences are effected at the level of antigen handling and presentation we have examined the ef...
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| Veröffentlicht in: | Journal of investigative dermatology 1992-11, Vol.99 (5), p.S107-S108 |
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| container_end_page | S108 |
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| container_issue | 5 |
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| container_title | Journal of investigative dermatology |
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| creator | Cumberbatch, Marie Gould, Sarah J Peters, Stephen W Basketter, David A Dearman, Rebecca J Kimber, Ian |
| description | Respiratory and contact chemical allergens provoke differential immune responses in mice, stimulating preferentially T helper-2 (TH2) and TH1 cells, respectively. In an attempt to discover whether such differences are effected at the level of antigen handling and presentation we have examined the effect of topical exposure to trimellitic anhydride (TMA), a respiratory allergen, and 2,4-dinitrochlorobenzene (DNCB), a contact allergen, on Langerhans cell (LC) MHC class II (Ia) expression. Neither chemical caused a significant change in LC size. As measured by analytical flow cytometry, exposure to DNCB resulted in a time-dependent increase in LC Ia expression that exceeded 160% of control values within 24h. Exposure to concentrations of TMA that caused an equivalent activation of draining lymph nodes failed to affect Ia expression by LC. Application of sodium lauryl sulfate at concentrations that caused edema also failed to influence LC Ia. These data demonstrate that TMA and DNCB exert differential effects on epidermal LC, possibly indicative of differences in antigen handling. |
| doi_str_mv | 10.1111/1523-1747.ep12669992 |
| format | Article |
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In an attempt to discover whether such differences are effected at the level of antigen handling and presentation we have examined the effect of topical exposure to trimellitic anhydride (TMA), a respiratory allergen, and 2,4-dinitrochlorobenzene (DNCB), a contact allergen, on Langerhans cell (LC) MHC class II (Ia) expression. Neither chemical caused a significant change in LC size. As measured by analytical flow cytometry, exposure to DNCB resulted in a time-dependent increase in LC Ia expression that exceeded 160% of control values within 24h. Exposure to concentrations of TMA that caused an equivalent activation of draining lymph nodes failed to affect Ia expression by LC. Application of sodium lauryl sulfate at concentrations that caused edema also failed to influence LC Ia. These data demonstrate that TMA and DNCB exert differential effects on epidermal LC, possibly indicative of differences in antigen handling.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1111/1523-1747.ep12669992</identifier><identifier>PMID: 1431198</identifier><identifier>CODEN: JIDEAE</identifier><language>eng</language><publisher>Danvers, MA: Elsevier Inc</publisher><subject>Allergens ; Allergens - adverse effects ; Animals ; Antigen presentation ; Antigen-Presenting Cells ; Antigens, allergens ; Biological and medical sciences ; Data processing ; Dermatitis, Contact - etiology ; Dermatology ; Dinitrochlorobenzene - adverse effects ; Drug Hypersensitivity - etiology ; Edema ; Flow cytometry ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Helper cells ; Hypersensitivity, Immediate - chemically induced ; Immediate hypersensitivity. Allergy. Anaphylaxis, etc ; Immune response ; Immunobiology ; Langerhans Cells ; Lymph nodes ; Lymphocytes T ; Major histocompatibility complex ; Mice ; Phthalic Anhydrides - adverse effects ; Phthalic Anhydrides - immunology ; Respiratory Hypersensitivity - chemically induced ; Sodium lauryl sulfate ; trimellitic anhydride</subject><ispartof>Journal of investigative dermatology, 1992-11, Vol.99 (5), p.S107-S108</ispartof><rights>1992 The Society for Investigative Dermatology, Inc</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-cb05e36a32f5fd79bb7086f809b834e5cb2de4f0902f9ce4cc9a7a9a0a9edde03</citedby><cites>FETCH-LOGICAL-c465t-cb05e36a32f5fd79bb7086f809b834e5cb2de4f0902f9ce4cc9a7a9a0a9edde03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23909,23910,25118,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4443684$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1431198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cumberbatch, Marie</creatorcontrib><creatorcontrib>Gould, Sarah J</creatorcontrib><creatorcontrib>Peters, Stephen W</creatorcontrib><creatorcontrib>Basketter, David A</creatorcontrib><creatorcontrib>Dearman, Rebecca J</creatorcontrib><creatorcontrib>Kimber, Ian</creatorcontrib><title>Langerhans Cells, Antigen Presentation, and the Diversity of Responses to Chemical Allergens</title><title>Journal of investigative dermatology</title><addtitle>J Invest Dermatol</addtitle><description>Respiratory and contact chemical allergens provoke differential immune responses in mice, stimulating preferentially T helper-2 (TH2) and TH1 cells, respectively. In an attempt to discover whether such differences are effected at the level of antigen handling and presentation we have examined the effect of topical exposure to trimellitic anhydride (TMA), a respiratory allergen, and 2,4-dinitrochlorobenzene (DNCB), a contact allergen, on Langerhans cell (LC) MHC class II (Ia) expression. Neither chemical caused a significant change in LC size. As measured by analytical flow cytometry, exposure to DNCB resulted in a time-dependent increase in LC Ia expression that exceeded 160% of control values within 24h. Exposure to concentrations of TMA that caused an equivalent activation of draining lymph nodes failed to affect Ia expression by LC. Application of sodium lauryl sulfate at concentrations that caused edema also failed to influence LC Ia. These data demonstrate that TMA and DNCB exert differential effects on epidermal LC, possibly indicative of differences in antigen handling.</description><subject>Allergens</subject><subject>Allergens - adverse effects</subject><subject>Animals</subject><subject>Antigen presentation</subject><subject>Antigen-Presenting Cells</subject><subject>Antigens, allergens</subject><subject>Biological and medical sciences</subject><subject>Data processing</subject><subject>Dermatitis, Contact - etiology</subject><subject>Dermatology</subject><subject>Dinitrochlorobenzene - adverse effects</subject><subject>Drug Hypersensitivity - etiology</subject><subject>Edema</subject><subject>Flow cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Helper cells</subject><subject>Hypersensitivity, Immediate - chemically induced</subject><subject>Immediate hypersensitivity. Allergy. Anaphylaxis, etc</subject><subject>Immune response</subject><subject>Immunobiology</subject><subject>Langerhans Cells</subject><subject>Lymph nodes</subject><subject>Lymphocytes T</subject><subject>Major histocompatibility complex</subject><subject>Mice</subject><subject>Phthalic Anhydrides - adverse effects</subject><subject>Phthalic Anhydrides - immunology</subject><subject>Respiratory Hypersensitivity - chemically induced</subject><subject>Sodium lauryl sulfate</subject><subject>trimellitic anhydride</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtrGzEURkVoSd00_yAFLbroIpNIGmlmtAkYpy8wJIQWuggIjeYqVhhrXF05kH8fGZtkV20E-s596BByxtkFL-eSK1FXvJXtBWy4aBqttTgis9fnd2TGmBCVYOLvB_IR8ZEx3kjVHZNjLmvOdTcj90sbHyCtbES6gHHEczqPOTxApLcJEGK2OUzxnNo40LwCeh2eIGHIz3Ty9A5wM0UEpHmiixWsg7MjnY8jpNIBP5H33o4Ip4f7hPz5_u334me1vPnxazFfVk42KleuZwrqxtbCKz-0uu9b1jW-Y7rvagnK9WIA6ZlmwmsH0jltW6stsxqGAVh9Qr7u-27S9G8LmM06oCu_sRGmLRouOsU6JaUqqNyjLk2ICbzZpLC26dlwZnZazc6f2fkzb1pL2efDhG2_huGtaO-x5F8OucWiwCcbXcBXTEpZN50s2NUeg2LjKUAy6AJEB0NI4LIZpvD_PV4AoB6U3w</recordid><startdate>19921101</startdate><enddate>19921101</enddate><creator>Cumberbatch, Marie</creator><creator>Gould, Sarah J</creator><creator>Peters, Stephen W</creator><creator>Basketter, David A</creator><creator>Dearman, Rebecca J</creator><creator>Kimber, Ian</creator><general>Elsevier Inc</general><general>Nature Publishing</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19921101</creationdate><title>Langerhans Cells, Antigen Presentation, and the Diversity of Responses to Chemical Allergens</title><author>Cumberbatch, Marie ; Gould, Sarah J ; Peters, Stephen W ; Basketter, David A ; Dearman, Rebecca J ; Kimber, Ian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-cb05e36a32f5fd79bb7086f809b834e5cb2de4f0902f9ce4cc9a7a9a0a9edde03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Allergens</topic><topic>Allergens - adverse effects</topic><topic>Animals</topic><topic>Antigen presentation</topic><topic>Antigen-Presenting Cells</topic><topic>Antigens, allergens</topic><topic>Biological and medical sciences</topic><topic>Data processing</topic><topic>Dermatitis, Contact - etiology</topic><topic>Dermatology</topic><topic>Dinitrochlorobenzene - adverse effects</topic><topic>Drug Hypersensitivity - etiology</topic><topic>Edema</topic><topic>Flow cytometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Helper cells</topic><topic>Hypersensitivity, Immediate - chemically induced</topic><topic>Immediate hypersensitivity. Allergy. Anaphylaxis, etc</topic><topic>Immune response</topic><topic>Immunobiology</topic><topic>Langerhans Cells</topic><topic>Lymph nodes</topic><topic>Lymphocytes T</topic><topic>Major histocompatibility complex</topic><topic>Mice</topic><topic>Phthalic Anhydrides - adverse effects</topic><topic>Phthalic Anhydrides - immunology</topic><topic>Respiratory Hypersensitivity - chemically induced</topic><topic>Sodium lauryl sulfate</topic><topic>trimellitic anhydride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cumberbatch, Marie</creatorcontrib><creatorcontrib>Gould, Sarah J</creatorcontrib><creatorcontrib>Peters, Stephen W</creatorcontrib><creatorcontrib>Basketter, David A</creatorcontrib><creatorcontrib>Dearman, Rebecca J</creatorcontrib><creatorcontrib>Kimber, Ian</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cumberbatch, Marie</au><au>Gould, Sarah J</au><au>Peters, Stephen W</au><au>Basketter, David A</au><au>Dearman, Rebecca J</au><au>Kimber, Ian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Langerhans Cells, Antigen Presentation, and the Diversity of Responses to Chemical Allergens</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>1992-11-01</date><risdate>1992</risdate><volume>99</volume><issue>5</issue><spage>S107</spage><epage>S108</epage><pages>S107-S108</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><coden>JIDEAE</coden><abstract>Respiratory and contact chemical allergens provoke differential immune responses in mice, stimulating preferentially T helper-2 (TH2) and TH1 cells, respectively. In an attempt to discover whether such differences are effected at the level of antigen handling and presentation we have examined the effect of topical exposure to trimellitic anhydride (TMA), a respiratory allergen, and 2,4-dinitrochlorobenzene (DNCB), a contact allergen, on Langerhans cell (LC) MHC class II (Ia) expression. Neither chemical caused a significant change in LC size. As measured by analytical flow cytometry, exposure to DNCB resulted in a time-dependent increase in LC Ia expression that exceeded 160% of control values within 24h. Exposure to concentrations of TMA that caused an equivalent activation of draining lymph nodes failed to affect Ia expression by LC. Application of sodium lauryl sulfate at concentrations that caused edema also failed to influence LC Ia. These data demonstrate that TMA and DNCB exert differential effects on epidermal LC, possibly indicative of differences in antigen handling.</abstract><cop>Danvers, MA</cop><pub>Elsevier Inc</pub><pmid>1431198</pmid><doi>10.1111/1523-1747.ep12669992</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Allergens Allergens - adverse effects Animals Antigen presentation Antigen-Presenting Cells Antigens, allergens Biological and medical sciences Data processing Dermatitis, Contact - etiology Dermatology Dinitrochlorobenzene - adverse effects Drug Hypersensitivity - etiology Edema Flow cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Helper cells Hypersensitivity, Immediate - chemically induced Immediate hypersensitivity. Allergy. Anaphylaxis, etc Immune response Immunobiology Langerhans Cells Lymph nodes Lymphocytes T Major histocompatibility complex Mice Phthalic Anhydrides - adverse effects Phthalic Anhydrides - immunology Respiratory Hypersensitivity - chemically induced Sodium lauryl sulfate trimellitic anhydride |
| title | Langerhans Cells, Antigen Presentation, and the Diversity of Responses to Chemical Allergens |
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