Induction of Suppressor T Cells and Inhibition of Contact Hypersensitivity in Mice by 12-O-Tetradecanoylphorbol-13-Acetate and Its Analogs

12-O-tetradecanoylphorbol-13-acetate (TPA) and its analogs were surveyed for their abilities to modify contact hyper-sensitivity (CHS) responses in SENCAR mice. Sensitization of dorsal skin with 2,4-dinitrofluorobenzene (DNFB) and subsequent challenge of the ear 5 d later resulted within 24h in ear...

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Veröffentlicht in:	Journal of investigative dermatology 1991-06, Vol.96 (6), p.864-870
Hauptverfasser:	Kodari, Effat, Pavone, Amy, Reiners, John J.
Format:	Artikel
Sprache:	eng
Schlagworte:	12-O-Tetradecanoylphorbol-13-acetate Adherent cells Administration, Cutaneous Adoptive transfer Animals Biological and medical sciences Capillary Permeability - drug effects Carcinogenesis Contact dermatitis Dermatitis, Contact - immunology Dermatitis, Contact - prevention & control Dermatology Dinitrofluorobenzene Ear Epidermis Extravasation Female Fundamental and applied biological sciences. Psychology Fundamental immunology Haptens Immunobiology Immunotherapy, Adoptive Kinetics Langerhans Cells - cytology Langerhans Cells - drug effects Lymphocytes T Mice Modulation of the immune response (stimulation, suppression) Monocytes oxazolone Permeability Promoters Skin Splenocytes Suppressor cells T-Lymphocytes, Regulatory - drug effects Terpenes - pharmacology Tetradecanoylphorbol Acetate - pharmacology TPA Tumors
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