Interaction of the human topoisomerase I-DNA complex with oligo-1,3-thiazolecarboxamides and their oligonucleotide conjugates

Nonnatural thiazole-containing oligopeptides (TCOs) bind to the DNA minor groove and inhibit the reaction catalyzed by human topoisomerase I (TopoI). The effect is directly proportional to the number of thiazole monomers in TCO. Several TCOs with three or four thiazole monomers act 3–10 times more e...

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Veröffentlicht in:	Molecular biology (New York) 2000-05, Vol.34 (3), p.356-362
Hauptverfasser:	Vasyutina, E L, Bugreev, D V, Ryabinin, V A, Sinyakov, A N, Buneva, V N, Nevinskii, G A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Bacteria Deoxyribonucleic acid Distamycin DNA DNA topoisomerase Imidazole Monomers Oligonucleotides Oligopeptides pyrroles thiazoles
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