Ultraviolet Radiation-induced Suppression of Contact Hypersensitivity in Relation to Padimate O and Oxybenzone
Contact hypersensitivity (CHS) in mice can be induced by cutaneous sensitization followed by elicitation via ear-painting with trinitrochlorobenzene (TNCB). This CHS reaction is systemic and can be suppressed by exposure of mice to suberythemogenic doses of 280-315nm radiation. In this study, we inv...
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| Veröffentlicht in: | Journal of investigative dermatology 1989-03, Vol.92 (3), p.337-341 |
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| container_title | Journal of investigative dermatology |
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| creator | Fisher, Michael S. Menter, Julian M. Willis, Isaac |
| description | Contact hypersensitivity (CHS) in mice can be induced by cutaneous sensitization followed by elicitation via ear-painting with trinitrochlorobenzene (TNCB). This CHS reaction is systemic and can be suppressed by exposure of mice to suberythemogenic doses of 280-315nm radiation. In this study, we investigated whether a commercially available water-resistant sunscreen, either SPF-6 or SPF-15, containing Padimate O (UVB absorber) and oxybenzone (UVA absorber), was effective in preventing systemic suppression of CHS induced by either FS36 sunlamp exposure or solar simulating radiation. We observed that these two sunscreen preparations were totally incapable of preventing the immunologic suppression of contact hypersensitivity by UV radiation. These results indicate that application of sunscreen does not retard the development of suppression of CHS following repeated UV exposure under conditions where erythema is not clinically observed. Thus, erythema may not be a good end point for assessing systemic immune suppression and its consequences. |
| doi_str_mv | 10.1111/1523-1747.ep12277156 |
| format | Article |
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This CHS reaction is systemic and can be suppressed by exposure of mice to suberythemogenic doses of 280-315nm radiation. In this study, we investigated whether a commercially available water-resistant sunscreen, either SPF-6 or SPF-15, containing Padimate O (UVB absorber) and oxybenzone (UVA absorber), was effective in preventing systemic suppression of CHS induced by either FS36 sunlamp exposure or solar simulating radiation. We observed that these two sunscreen preparations were totally incapable of preventing the immunologic suppression of contact hypersensitivity by UV radiation. These results indicate that application of sunscreen does not retard the development of suppression of CHS following repeated UV exposure under conditions where erythema is not clinically observed. Thus, erythema may not be a good end point for assessing systemic immune suppression and its consequences.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1111/1523-1747.ep12277156</identifier><identifier>PMID: 2783954</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>4-Aminobenzoic Acid - pharmacology ; Aminobenzoates - pharmacology ; Animals ; Benzophenones - pharmacology ; Contact dermatitis ; Dermatitis, Contact - immunology ; Dermatology ; Dose-Response Relationship, Radiation ; Erythema ; Erythema - etiology ; Erythema - immunology ; Immune Tolerance - drug effects ; Immune Tolerance - radiation effects ; Mice ; Mice, Hairless ; para-Aminobenzoates ; Sunscreening Agents - pharmacology ; Sunscreens ; trinitrochlorobenzene ; U.V. radiation ; Ultraviolet Rays</subject><ispartof>Journal of investigative dermatology, 1989-03, Vol.92 (3), p.337-341</ispartof><rights>1989 The Society for Investigative Dermatology, Inc</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-f91e5a174cad0cf4073e09426bdb8f91619ea56d49634bb9f9d5014392b1a0c63</citedby><cites>FETCH-LOGICAL-c436t-f91e5a174cad0cf4073e09426bdb8f91619ea56d49634bb9f9d5014392b1a0c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2783954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fisher, Michael S.</creatorcontrib><creatorcontrib>Menter, Julian M.</creatorcontrib><creatorcontrib>Willis, Isaac</creatorcontrib><title>Ultraviolet Radiation-induced Suppression of Contact Hypersensitivity in Relation to Padimate O and Oxybenzone</title><title>Journal of investigative dermatology</title><addtitle>J Invest Dermatol</addtitle><description>Contact hypersensitivity (CHS) in mice can be induced by cutaneous sensitization followed by elicitation via ear-painting with trinitrochlorobenzene (TNCB). This CHS reaction is systemic and can be suppressed by exposure of mice to suberythemogenic doses of 280-315nm radiation. In this study, we investigated whether a commercially available water-resistant sunscreen, either SPF-6 or SPF-15, containing Padimate O (UVB absorber) and oxybenzone (UVA absorber), was effective in preventing systemic suppression of CHS induced by either FS36 sunlamp exposure or solar simulating radiation. We observed that these two sunscreen preparations were totally incapable of preventing the immunologic suppression of contact hypersensitivity by UV radiation. These results indicate that application of sunscreen does not retard the development of suppression of CHS following repeated UV exposure under conditions where erythema is not clinically observed. Thus, erythema may not be a good end point for assessing systemic immune suppression and its consequences.</description><subject>4-Aminobenzoic Acid - pharmacology</subject><subject>Aminobenzoates - pharmacology</subject><subject>Animals</subject><subject>Benzophenones - pharmacology</subject><subject>Contact dermatitis</subject><subject>Dermatitis, Contact - immunology</subject><subject>Dermatology</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Erythema</subject><subject>Erythema - etiology</subject><subject>Erythema - immunology</subject><subject>Immune Tolerance - drug effects</subject><subject>Immune Tolerance - radiation effects</subject><subject>Mice</subject><subject>Mice, Hairless</subject><subject>para-Aminobenzoates</subject><subject>Sunscreening Agents - pharmacology</subject><subject>Sunscreens</subject><subject>trinitrochlorobenzene</subject><subject>U.V. radiation</subject><subject>Ultraviolet Rays</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQhkVJcZ2k_6ABHXNZV9JqP3QJBJM2hYBDmkBvQivNgsJa2kpak-2vj1wb99a5DMw773w8CH2hZEVzfKUVKwva8GYFI2WsaWhVf0DLU_kMLQlhrGCE_fqEzmN8JYTWvGoXaMGathQVXyL3MqSgdtYPkPCTMlYl611hnZk0GPxzGscAMeYa9j1ee5eUTvh-HiFEcNEmu7NpxtbhJxj-enHy-DEP2qoEeIOVM3jzNnfg_ngHl-hjr4YIn4_5Ar18u3te3xcPm-8_1rcPheZlnYpeUKhUfkIrQ3TPSVMCEZzVnenaLNZUgKpqw0Vd8q4TvTAVobwUrKOK6Lq8QNeHuWPwvyeISW5t1DAMyoGfoqSsrUhbEkFzKz-06uBjDNDLMeTjwywpkXvQck9U7onKf6Cz7eq4Yeq2YE6mI9ms3xx0yG_uLAQZtQWXodoAOknj7f8XvAPts47V</recordid><startdate>19890301</startdate><enddate>19890301</enddate><creator>Fisher, Michael S.</creator><creator>Menter, Julian M.</creator><creator>Willis, Isaac</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19890301</creationdate><title>Ultraviolet Radiation-induced Suppression of Contact Hypersensitivity in Relation to Padimate O and Oxybenzone</title><author>Fisher, Michael S. ; Menter, Julian M. ; Willis, Isaac</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-f91e5a174cad0cf4073e09426bdb8f91619ea56d49634bb9f9d5014392b1a0c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>4-Aminobenzoic Acid - pharmacology</topic><topic>Aminobenzoates - pharmacology</topic><topic>Animals</topic><topic>Benzophenones - pharmacology</topic><topic>Contact dermatitis</topic><topic>Dermatitis, Contact - immunology</topic><topic>Dermatology</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Erythema</topic><topic>Erythema - etiology</topic><topic>Erythema - immunology</topic><topic>Immune Tolerance - drug effects</topic><topic>Immune Tolerance - radiation effects</topic><topic>Mice</topic><topic>Mice, Hairless</topic><topic>para-Aminobenzoates</topic><topic>Sunscreening Agents - pharmacology</topic><topic>Sunscreens</topic><topic>trinitrochlorobenzene</topic><topic>U.V. radiation</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fisher, Michael S.</creatorcontrib><creatorcontrib>Menter, Julian M.</creatorcontrib><creatorcontrib>Willis, Isaac</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fisher, Michael S.</au><au>Menter, Julian M.</au><au>Willis, Isaac</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultraviolet Radiation-induced Suppression of Contact Hypersensitivity in Relation to Padimate O and Oxybenzone</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>1989-03-01</date><risdate>1989</risdate><volume>92</volume><issue>3</issue><spage>337</spage><epage>341</epage><pages>337-341</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><abstract>Contact hypersensitivity (CHS) in mice can be induced by cutaneous sensitization followed by elicitation via ear-painting with trinitrochlorobenzene (TNCB). This CHS reaction is systemic and can be suppressed by exposure of mice to suberythemogenic doses of 280-315nm radiation. In this study, we investigated whether a commercially available water-resistant sunscreen, either SPF-6 or SPF-15, containing Padimate O (UVB absorber) and oxybenzone (UVA absorber), was effective in preventing systemic suppression of CHS induced by either FS36 sunlamp exposure or solar simulating radiation. We observed that these two sunscreen preparations were totally incapable of preventing the immunologic suppression of contact hypersensitivity by UV radiation. These results indicate that application of sunscreen does not retard the development of suppression of CHS following repeated UV exposure under conditions where erythema is not clinically observed. Thus, erythema may not be a good end point for assessing systemic immune suppression and its consequences.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>2783954</pmid><doi>10.1111/1523-1747.ep12277156</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | 4-Aminobenzoic Acid - pharmacology Aminobenzoates - pharmacology Animals Benzophenones - pharmacology Contact dermatitis Dermatitis, Contact - immunology Dermatology Dose-Response Relationship, Radiation Erythema Erythema - etiology Erythema - immunology Immune Tolerance - drug effects Immune Tolerance - radiation effects Mice Mice, Hairless para-Aminobenzoates Sunscreening Agents - pharmacology Sunscreens trinitrochlorobenzene U.V. radiation Ultraviolet Rays |
| title | Ultraviolet Radiation-induced Suppression of Contact Hypersensitivity in Relation to Padimate O and Oxybenzone |
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