Cyclosporin A causes impairment of the ventral prostate tissue structure of Wistar rats

Cyclosporin A (CsA) is an immunosuppressive drug widely used in medicine to reduce the immune system activity and, therefore, the risk of organ rejection after transplantation. However, many side effects can be related to its use, such as, reduction in serum testosterone levels due to damage of the...

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Veröffentlicht in:	Human & experimental toxicology 2012-12, Vol.31 (12), p.1262-1270
Hauptverfasser:	Freitas, KM, Monteiro, JC, Gomes, MLM, Taboga, SR, Dolder, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen receptors Animals Apoptosis - drug effects Atrophy - chemically induced Atrophy - pathology Blood Glucose - analysis Cyclosporine - toxicity Epithelial Cells - drug effects Epithelial Cells - pathology Epithelial Cells - ultrastructure Image Processing, Computer-Assisted Immunohistochemistry - methods Immunosuppressive Agents - toxicity Male Organ Size - drug effects Prostate Prostate - drug effects Prostate - metabolism Prostate - pathology Rats Rats, Wistar Receptors, Androgen - metabolism Rodents Testosterone - blood Tissues
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