Glucose Sensing via Aggregation and the Use of “Knock-Out” Binding To Improve Selectivity

Glucose Sensing via Aggregation and the Use of “Knock-Out” Binding To Improve Selectivity

Aggregates of an amphiphilic monoboronic acid bearing a hydrophobic pyrene fluorophore were employed for highly modulating, sensitive, and selective ratiometric fluorescent sensing of glucose in aqueous solution. The selectivity for glucose was improved by “knock-out” binding of fructose by phenylbo...

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Veröffentlicht in:Journal of the American Chemical Society 2013-02, Vol.135 (5), p.1700-1703
Hauptverfasser: Huang, Yan-Jun, Ouyang, Wen-Juan, Wu, Xin, Li, Zhao, Fossey, John S, James, Tony D, Jiang, Yun-Bao
Format: Artikel
Sprache:eng
Schlagworte:
Binding Sites
Boronic Acids - chemistry
Fluorescent Dyes - chemistry
Fructose - chemistry
Glucose - analysis
Hydrophobic and Hydrophilic Interactions
Models, Molecular
Molecular Structure
Pyrenes - chemistry
Spectrometry, Fluorescence
Substrate Specificity
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Zusammenfassung:Aggregates of an amphiphilic monoboronic acid bearing a hydrophobic pyrene fluorophore were employed for highly modulating, sensitive, and selective ratiometric fluorescent sensing of glucose in aqueous solution. The selectivity for glucose was improved by “knock-out” binding of fructose by phenylboronic acid.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja311442x