Peptide hormone ghrelin enhances neuronal excitability by inhibition of Kv7/KCNQ channels

The gut-derived orexigenic peptide hormone ghrelin enhances neuronal firing in the substantia nigra pars compacta, where dopaminergic neurons modulate the function of the nigrostriatal system for motor coordination. Here we describe a novel mechanism by which ghrelin enhances firing of nigral dopami...

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Veröffentlicht in:	Nature communications 2013, Vol.4 (1), p.1435-1435, Article 1435
Hauptverfasser:	Shi, Limin, Bian, Xiling, Qu, Zhiqiang, Ma, Zegang, Zhou, Yu, Wang, KeWei, Jiang, Hong, Xie, Junxia
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1697/2601 631/80/86 Action Potentials - drug effects Animals CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - physiology Catalepsy - metabolism Catalepsy - physiopathology Cyclic AMP-Dependent Protein Kinases - metabolism Dopamine - metabolism Dopaminergic Neurons - drug effects Dopaminergic Neurons - enzymology Dopaminergic Neurons - physiology Ganglia, Spinal - drug effects Ganglia, Spinal - physiology Ghrelin - administration & dosage Ghrelin - pharmacology Haloperidol Humanities and Social Sciences Injections, Intraventricular KCNQ Potassium Channels - antagonists & inhibitors KCNQ Potassium Channels - metabolism Mice Mice, Transgenic multidisciplinary Nystatin - pharmacology Potassium Channel Blockers - pharmacology Pyramidal Cells - drug effects Pyramidal Cells - physiology Rats Receptors, Ghrelin - metabolism Science Science (multidisciplinary) Signal Transduction - drug effects Substantia Nigra - drug effects Substantia Nigra - physiology Type C Phospholipases - metabolism
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