Cholestatic pruritus: a retrospective analysis on clinical characteristics and treatment response
Summary Background: Chronic cholestatic pruritus (ChP) is caused by various hepatobiliary disorders. This retrospective study describes the distribution of underlying diseases, clinical characteristics and treatment efficacy in a consecutive collective of patients with ChP. Patients and methods: Ext...
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| Veröffentlicht in: | Journal der Deutschen Dermatologischen Gesellschaft 2013-02, Vol.11 (2), p.158-168 |
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| creator | Huesmann, Mario Huesmann, Timo Osada, Nani Phan, Ngoc Quan Kremer, Andreas E. Ständer, Sonja |
| description | Summary
Background: Chronic cholestatic pruritus (ChP) is caused by various hepatobiliary disorders. This retrospective study describes the distribution of underlying diseases, clinical characteristics and treatment efficacy in a consecutive collective of patients with ChP.
Patients and methods: Extensive data from 60 patients with ChP (30 women, 30 men; mean age: 58.0 ± 17.0 years) were retrospectively statistically analyzed concerning demographic data, pruritus characteristics, and response to therapy.
Results: In this study population, 40.0% of the patients suffered from hepatitis B or C. Regarding the overall population, pruritus started in 50% of patients after diagnosis of the underlying hepatobiliary disorder. Only in patients with immune‐mediated liver diseases did pruritus more often occur before diagnosis (p < 0.05). Only 23.3% of the patients reported an initial palmoplantar pruritus. Along with other drugs, anticonvulsants proved to be an effective treatment regime.
Conclusions: In this study, viral pathogenesis was the most common cause of ChP. Other underlying diseases were represented to a lower extent in the total study population. Overall, the collected clinical parameters in each group were comparable. Thus, it was difficult to draw conclusions on the pathogenesis. |
| doi_str_mv | 10.1111/j.1610-0387.2012.08028.x |
| format | Article |
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Background: Chronic cholestatic pruritus (ChP) is caused by various hepatobiliary disorders. This retrospective study describes the distribution of underlying diseases, clinical characteristics and treatment efficacy in a consecutive collective of patients with ChP.
Patients and methods: Extensive data from 60 patients with ChP (30 women, 30 men; mean age: 58.0 ± 17.0 years) were retrospectively statistically analyzed concerning demographic data, pruritus characteristics, and response to therapy.
Results: In this study population, 40.0% of the patients suffered from hepatitis B or C. Regarding the overall population, pruritus started in 50% of patients after diagnosis of the underlying hepatobiliary disorder. Only in patients with immune‐mediated liver diseases did pruritus more often occur before diagnosis (p < 0.05). Only 23.3% of the patients reported an initial palmoplantar pruritus. Along with other drugs, anticonvulsants proved to be an effective treatment regime.
Conclusions: In this study, viral pathogenesis was the most common cause of ChP. Other underlying diseases were represented to a lower extent in the total study population. Overall, the collected clinical parameters in each group were comparable. Thus, it was difficult to draw conclusions on the pathogenesis.</description><identifier>ISSN: 1610-0379</identifier><identifier>EISSN: 1610-0387</identifier><identifier>DOI: 10.1111/j.1610-0387.2012.08028.x</identifier><identifier>PMID: 23190476</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Age Distribution ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Cholestasis - diagnosis ; Cholestasis - epidemiology ; Cholestasis - therapy ; Chronic Disease ; Comorbidity ; Female ; Germany - epidemiology ; Humans ; Incidence ; Male ; Middle Aged ; Pruritus - diagnosis ; Pruritus - epidemiology ; Pruritus - therapy ; Retrospective Studies ; Risk Assessment ; Sex Distribution ; Treatment Outcome ; Young Adult</subject><ispartof>Journal der Deutschen Dermatologischen Gesellschaft, 2013-02, Vol.11 (2), p.158-168</ispartof><rights>The Authors | Journal compilation © Blackwell Verlag GmbH, Berlin</rights><rights>The Authors | Journal compilation © Blackwell Verlag GmbH, Berlin.</rights><rights>Copyright The Authors | Journal compilation Copyright Blackwell Verlag GmbH, Berlin</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4358-89d63d6b2ac1d98dc25598e80194d8a7ab35af719bb541a699a2215201c29c4b3</citedby><cites>FETCH-LOGICAL-c4358-89d63d6b2ac1d98dc25598e80194d8a7ab35af719bb541a699a2215201c29c4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1610-0387.2012.08028.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1610-0387.2012.08028.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23190476$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huesmann, Mario</creatorcontrib><creatorcontrib>Huesmann, Timo</creatorcontrib><creatorcontrib>Osada, Nani</creatorcontrib><creatorcontrib>Phan, Ngoc Quan</creatorcontrib><creatorcontrib>Kremer, Andreas E.</creatorcontrib><creatorcontrib>Ständer, Sonja</creatorcontrib><title>Cholestatic pruritus: a retrospective analysis on clinical characteristics and treatment response</title><title>Journal der Deutschen Dermatologischen Gesellschaft</title><addtitle>J Dtsch Dermatol Ges</addtitle><description>Summary
Background: Chronic cholestatic pruritus (ChP) is caused by various hepatobiliary disorders. This retrospective study describes the distribution of underlying diseases, clinical characteristics and treatment efficacy in a consecutive collective of patients with ChP.
Patients and methods: Extensive data from 60 patients with ChP (30 women, 30 men; mean age: 58.0 ± 17.0 years) were retrospectively statistically analyzed concerning demographic data, pruritus characteristics, and response to therapy.
Results: In this study population, 40.0% of the patients suffered from hepatitis B or C. Regarding the overall population, pruritus started in 50% of patients after diagnosis of the underlying hepatobiliary disorder. Only in patients with immune‐mediated liver diseases did pruritus more often occur before diagnosis (p < 0.05). Only 23.3% of the patients reported an initial palmoplantar pruritus. Along with other drugs, anticonvulsants proved to be an effective treatment regime.
Conclusions: In this study, viral pathogenesis was the most common cause of ChP. Other underlying diseases were represented to a lower extent in the total study population. Overall, the collected clinical parameters in each group were comparable. Thus, it was difficult to draw conclusions on the pathogenesis.</description><subject>Adolescent</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cholestasis - diagnosis</subject><subject>Cholestasis - epidemiology</subject><subject>Cholestasis - therapy</subject><subject>Chronic Disease</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Germany - epidemiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pruritus - diagnosis</subject><subject>Pruritus - epidemiology</subject><subject>Pruritus - therapy</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Sex Distribution</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>1610-0379</issn><issn>1610-0387</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxa0K1JaWr1BZ6oVLgv_Ejl2JA9qFBakFVSriaE0cr-ptNgm2A7vfHocte-CELx5pfm9G7w1CmJKS5vd2U1JJSUG4qktGKCuJIkyVuxN0fmy8ONa1PkOvYtwQwoQi5BSdMU41qWp5jmDxOHQuJkje4jFMwacp3mDAwaUwxNHZ5H86DD10--gjHnpsO997Cx22jxDAJhd8zOqYoRan4CBtXZ_ygDgOfXSX6OUauuheP_8X6NvHDw-LT8Xt19XnxfvbwlZcqELpVvJWNgwsbbVqLRNCK6cI1VWroIaGC1jXVDeNqChIrYExKrJ7y7StGn6B3hzmjmH4MWVLZuujdV0HvRumaChTlWSVVjKj1_-gm2EK2WKmeJXX1oqSTKkDZXMQMbi1GYPfQtgbSsx8BrMxc8JmTtvMZzB_zmB2WXr1vGBqtq49Cv_mnoF3B-CX79z-vweb5XI1V1lfHPQ5erc76iE8GVnzWpjvX1bm7n55x-VCmAf-Gx2WpYg</recordid><startdate>201302</startdate><enddate>201302</enddate><creator>Huesmann, Mario</creator><creator>Huesmann, Timo</creator><creator>Osada, Nani</creator><creator>Phan, Ngoc Quan</creator><creator>Kremer, Andreas E.</creator><creator>Ständer, Sonja</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>201302</creationdate><title>Cholestatic pruritus: a retrospective analysis on clinical characteristics and treatment response</title><author>Huesmann, Mario ; Huesmann, Timo ; Osada, Nani ; Phan, Ngoc Quan ; Kremer, Andreas E. ; Ständer, Sonja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4358-89d63d6b2ac1d98dc25598e80194d8a7ab35af719bb541a699a2215201c29c4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cholestasis - diagnosis</topic><topic>Cholestasis - epidemiology</topic><topic>Cholestasis - therapy</topic><topic>Chronic Disease</topic><topic>Comorbidity</topic><topic>Female</topic><topic>Germany - epidemiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pruritus - diagnosis</topic><topic>Pruritus - epidemiology</topic><topic>Pruritus - therapy</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Sex Distribution</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huesmann, Mario</creatorcontrib><creatorcontrib>Huesmann, Timo</creatorcontrib><creatorcontrib>Osada, Nani</creatorcontrib><creatorcontrib>Phan, Ngoc Quan</creatorcontrib><creatorcontrib>Kremer, Andreas E.</creatorcontrib><creatorcontrib>Ständer, Sonja</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal der Deutschen Dermatologischen Gesellschaft</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huesmann, Mario</au><au>Huesmann, Timo</au><au>Osada, Nani</au><au>Phan, Ngoc Quan</au><au>Kremer, Andreas E.</au><au>Ständer, Sonja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cholestatic pruritus: a retrospective analysis on clinical characteristics and treatment response</atitle><jtitle>Journal der Deutschen Dermatologischen Gesellschaft</jtitle><addtitle>J Dtsch Dermatol Ges</addtitle><date>2013-02</date><risdate>2013</risdate><volume>11</volume><issue>2</issue><spage>158</spage><epage>168</epage><pages>158-168</pages><issn>1610-0379</issn><eissn>1610-0387</eissn><abstract>Summary
Background: Chronic cholestatic pruritus (ChP) is caused by various hepatobiliary disorders. This retrospective study describes the distribution of underlying diseases, clinical characteristics and treatment efficacy in a consecutive collective of patients with ChP.
Patients and methods: Extensive data from 60 patients with ChP (30 women, 30 men; mean age: 58.0 ± 17.0 years) were retrospectively statistically analyzed concerning demographic data, pruritus characteristics, and response to therapy.
Results: In this study population, 40.0% of the patients suffered from hepatitis B or C. Regarding the overall population, pruritus started in 50% of patients after diagnosis of the underlying hepatobiliary disorder. Only in patients with immune‐mediated liver diseases did pruritus more often occur before diagnosis (p < 0.05). Only 23.3% of the patients reported an initial palmoplantar pruritus. Along with other drugs, anticonvulsants proved to be an effective treatment regime.
Conclusions: In this study, viral pathogenesis was the most common cause of ChP. Other underlying diseases were represented to a lower extent in the total study population. Overall, the collected clinical parameters in each group were comparable. Thus, it was difficult to draw conclusions on the pathogenesis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>23190476</pmid><doi>10.1111/j.1610-0387.2012.08028.x</doi><tpages>11</tpages></addata></record> |
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| subjects | Adolescent Age Distribution Aged Aged, 80 and over Child Child, Preschool Cholestasis - diagnosis Cholestasis - epidemiology Cholestasis - therapy Chronic Disease Comorbidity Female Germany - epidemiology Humans Incidence Male Middle Aged Pruritus - diagnosis Pruritus - epidemiology Pruritus - therapy Retrospective Studies Risk Assessment Sex Distribution Treatment Outcome Young Adult |
| title | Cholestatic pruritus: a retrospective analysis on clinical characteristics and treatment response |
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