Reducing Effect of a Combination of Phaseolus vulgaris and Cynara scolymus Extracts on Food Intake and Glycemia in Rats
Extracts from Phaseolus vulgaris and Cynara scolymus may reduce food intake and/or postprandial glycemia. This study investigated the effect of standardized extracts of P. vulgaris and C. scolymus and their combination on food intake and glycemia in rats. P. vulgaris and C. scolymus extracts, and th...
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| Veröffentlicht in: | Phytotherapy research 2013-02, Vol.27 (2), p.258-263 |
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| creator | Loi, Barbara Fantini, Noemi Colombo, Giancarlo Gessa, Gian Luigi Riva, Antonella Bombardelli, Ezio Morazzoni, Paolo Carai, Mauro A. M |
| description | Extracts from Phaseolus vulgaris and Cynara scolymus may reduce food intake and/or postprandial glycemia. This study investigated the effect of standardized extracts of P. vulgaris and C. scolymus and their combination on food intake and glycemia in rats. P. vulgaris and C. scolymus extracts, and their 1:2 combination, were administered acutely to rats (a) given access to regular food and water, (b) given access to regular food, water, and a chocolate‐flavored beverage, or (c) infused with a starch bolus. P. vulgaris extract and the combination produced comparable reductions in intake of regular food and chocolate‐flavored beverage; conversely, C. scolymus extract was ineffective on both parameters. P. vulgaris and C. scolymus extracts additively contributed to the reducing effect of the combination on glycemic rise. These results suggest that a mixture of P. vulgaris and C. scolymus extracts is preferable over each single extract, as it combines the anorectic effect of the P. vulgaris extract with the hypoglycemic effect of both extracts. These data support the recent clinical use of the combination of P. vulgaris and C. scolymus extracts in the control of appetite, food intake, and postprandial glycemia and represent a successful example of translational research in the nutraceutical field. Copyright © 2012 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.4704 |
| format | Article |
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M</creator><creatorcontrib>Loi, Barbara ; Fantini, Noemi ; Colombo, Giancarlo ; Gessa, Gian Luigi ; Riva, Antonella ; Bombardelli, Ezio ; Morazzoni, Paolo ; Carai, Mauro A. M</creatorcontrib><description>Extracts from Phaseolus vulgaris and Cynara scolymus may reduce food intake and/or postprandial glycemia. This study investigated the effect of standardized extracts of P. vulgaris and C. scolymus and their combination on food intake and glycemia in rats. P. vulgaris and C. scolymus extracts, and their 1:2 combination, were administered acutely to rats (a) given access to regular food and water, (b) given access to regular food, water, and a chocolate‐flavored beverage, or (c) infused with a starch bolus. P. vulgaris extract and the combination produced comparable reductions in intake of regular food and chocolate‐flavored beverage; conversely, C. scolymus extract was ineffective on both parameters. P. vulgaris and C. scolymus extracts additively contributed to the reducing effect of the combination on glycemic rise. These results suggest that a mixture of P. vulgaris and C. scolymus extracts is preferable over each single extract, as it combines the anorectic effect of the P. vulgaris extract with the hypoglycemic effect of both extracts. These data support the recent clinical use of the combination of P. vulgaris and C. scolymus extracts in the control of appetite, food intake, and postprandial glycemia and represent a successful example of translational research in the nutraceutical field. Copyright © 2012 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.4704</identifier><identifier>PMID: 22565861</identifier><identifier>CODEN: PHYREH</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; appetite ; Appetite - drug effects ; Beverages ; blood glucose ; Blood Glucose - drug effects ; Cynara cardunculus ; Cynara scolymus (Asteraceae) extract ; Cynara scolymus - chemistry ; Eating - drug effects ; food intake ; glycemia ; glycemic effect ; Hypoglycemic Agents - pharmacology ; intake of a chocolate-flavored beverage ; intake of regular food pellets ; Male ; Phaseolus - chemistry ; Phaseolus vulgaris ; Phaseolus vulgaris (Fabaceae) extract ; Plant Extracts - pharmacology ; Rats ; Rats, Wistar ; starch</subject><ispartof>Phytotherapy research, 2013-02, Vol.27 (2), p.258-263</ispartof><rights>Copyright © 2012 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4114-d2df7457f5841e8d3f13e04321f182f1d18e7d8f0b3533458dda11edab6a72203</citedby><cites>FETCH-LOGICAL-c4114-d2df7457f5841e8d3f13e04321f182f1d18e7d8f0b3533458dda11edab6a72203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.4704$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.4704$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22565861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Loi, Barbara</creatorcontrib><creatorcontrib>Fantini, Noemi</creatorcontrib><creatorcontrib>Colombo, Giancarlo</creatorcontrib><creatorcontrib>Gessa, Gian Luigi</creatorcontrib><creatorcontrib>Riva, Antonella</creatorcontrib><creatorcontrib>Bombardelli, Ezio</creatorcontrib><creatorcontrib>Morazzoni, Paolo</creatorcontrib><creatorcontrib>Carai, Mauro A. M</creatorcontrib><title>Reducing Effect of a Combination of Phaseolus vulgaris and Cynara scolymus Extracts on Food Intake and Glycemia in Rats</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>Extracts from Phaseolus vulgaris and Cynara scolymus may reduce food intake and/or postprandial glycemia. This study investigated the effect of standardized extracts of P. vulgaris and C. scolymus and their combination on food intake and glycemia in rats. P. vulgaris and C. scolymus extracts, and their 1:2 combination, were administered acutely to rats (a) given access to regular food and water, (b) given access to regular food, water, and a chocolate‐flavored beverage, or (c) infused with a starch bolus. P. vulgaris extract and the combination produced comparable reductions in intake of regular food and chocolate‐flavored beverage; conversely, C. scolymus extract was ineffective on both parameters. P. vulgaris and C. scolymus extracts additively contributed to the reducing effect of the combination on glycemic rise. These results suggest that a mixture of P. vulgaris and C. scolymus extracts is preferable over each single extract, as it combines the anorectic effect of the P. vulgaris extract with the hypoglycemic effect of both extracts. These data support the recent clinical use of the combination of P. vulgaris and C. scolymus extracts in the control of appetite, food intake, and postprandial glycemia and represent a successful example of translational research in the nutraceutical field. Copyright © 2012 John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>appetite</subject><subject>Appetite - drug effects</subject><subject>Beverages</subject><subject>blood glucose</subject><subject>Blood Glucose - drug effects</subject><subject>Cynara cardunculus</subject><subject>Cynara scolymus (Asteraceae) extract</subject><subject>Cynara scolymus - chemistry</subject><subject>Eating - drug effects</subject><subject>food intake</subject><subject>glycemia</subject><subject>glycemic effect</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>intake of a chocolate-flavored beverage</subject><subject>intake of regular food pellets</subject><subject>Male</subject><subject>Phaseolus - chemistry</subject><subject>Phaseolus vulgaris</subject><subject>Phaseolus vulgaris (Fabaceae) extract</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>starch</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10k1v0zAcBnALgVgZSHwCsMSFS4Zf83KE0pVJA6psE7tZ_8Z28ZbExU7Y8u1xaRkSEidL9s-PLT9G6CUlJ5QQ9m47hBNREPEIzSipqozKgj9GM1JJmglaXh-hZzHeEEIqRsRTdMSYzGWZ0xm6q40eG9dv8MJa0wzYWwx47ru162Fwvt9NrL5DNL4dI_45thsILmLoNZ5PPQTAsfHt1KXFxf0QoBkiTrtOvdf4rB_g1vy2y3ZqTOcAux7XMMTn6ImFNpoXh_EYXZ0uLuefsvOvy7P5-_OsEZSKTDNtCyELK0tBTam5pdwQwRm1tGSWalqaQpeWrLnkXMhSa6DUaFjnUDBG-DF6u8_dBv9jNHFQnYuNaVvojR-joqwULL0KzxN98w-98WPo0-12iudESpH_DWyCjzEYq7bBdRAmRYnalaFSGWpXRqKvDoHjujP6Af55_QSyPbhzrZn-G6RWl_Uh8OBdHMz9g4dwq_KCF1J9-7JU1xf16sPnj5Wqk3-99xa8gk3qTV1dMEJF-gnphLLgvwBw0qq0</recordid><startdate>201302</startdate><enddate>201302</enddate><creator>Loi, Barbara</creator><creator>Fantini, Noemi</creator><creator>Colombo, Giancarlo</creator><creator>Gessa, Gian Luigi</creator><creator>Riva, Antonella</creator><creator>Bombardelli, Ezio</creator><creator>Morazzoni, Paolo</creator><creator>Carai, Mauro A. 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M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reducing Effect of a Combination of Phaseolus vulgaris and Cynara scolymus Extracts on Food Intake and Glycemia in Rats</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2013-02</date><risdate>2013</risdate><volume>27</volume><issue>2</issue><spage>258</spage><epage>263</epage><pages>258-263</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><coden>PHYREH</coden><abstract>Extracts from Phaseolus vulgaris and Cynara scolymus may reduce food intake and/or postprandial glycemia. This study investigated the effect of standardized extracts of P. vulgaris and C. scolymus and their combination on food intake and glycemia in rats. P. vulgaris and C. scolymus extracts, and their 1:2 combination, were administered acutely to rats (a) given access to regular food and water, (b) given access to regular food, water, and a chocolate‐flavored beverage, or (c) infused with a starch bolus. P. vulgaris extract and the combination produced comparable reductions in intake of regular food and chocolate‐flavored beverage; conversely, C. scolymus extract was ineffective on both parameters. P. vulgaris and C. scolymus extracts additively contributed to the reducing effect of the combination on glycemic rise. These results suggest that a mixture of P. vulgaris and C. scolymus extracts is preferable over each single extract, as it combines the anorectic effect of the P. vulgaris extract with the hypoglycemic effect of both extracts. These data support the recent clinical use of the combination of P. vulgaris and C. scolymus extracts in the control of appetite, food intake, and postprandial glycemia and represent a successful example of translational research in the nutraceutical field. Copyright © 2012 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>22565861</pmid><doi>10.1002/ptr.4704</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals appetite Appetite - drug effects Beverages blood glucose Blood Glucose - drug effects Cynara cardunculus Cynara scolymus (Asteraceae) extract Cynara scolymus - chemistry Eating - drug effects food intake glycemia glycemic effect Hypoglycemic Agents - pharmacology intake of a chocolate-flavored beverage intake of regular food pellets Male Phaseolus - chemistry Phaseolus vulgaris Phaseolus vulgaris (Fabaceae) extract Plant Extracts - pharmacology Rats Rats, Wistar starch |
| title | Reducing Effect of a Combination of Phaseolus vulgaris and Cynara scolymus Extracts on Food Intake and Glycemia in Rats |
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