Effective Assessment of egfr Mutation Status in Bronchoalveolar Lavage and Pleural Fluids by Next-Generation Sequencing

The therapeutic choice for patients with lung adenocarcinoma depends on the presence of EGF receptor (EGFR) mutations. In many cases, only cytologic samples are available for molecular diagnosis. Bronchoalveolar lavage (BAL) and pleural fluid, which represent a considerable proportion of cytologic s...

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Veröffentlicht in:	Clinical cancer research 2013-02, Vol.19 (3), p.691-698
Hauptverfasser:	BUTTITTA, Fiamma, FELICIONI, Lara, ROSINI, Sandra, CUCCURULLO, Franco, MARCHETTI, Antonio, DEL GRAMMASTRO, Maela, FILICE, Giampaolo, DI LORITO, Alessia, MALATESTA, Sara, VIOLA, Patrizia, CENTI, Irene, D'ANTUONO, Tommaso, ZAPPACOSTA, Roberta
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma of Lung Antineoplastic agents Biological and medical sciences Bronchoalveolar Lavage Fluid - chemistry DNA Mutational Analysis ErbB Receptors - genetics Exons High-Throughput Nucleotide Sequencing Humans Lung Neoplasms - genetics Medical sciences Mutation Pharmacology. Drug treatments Pleural Effusion, Malignant - chemistry
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