Membrane configuration optimization for a murine in vitro blood–brain barrier model

► A comprehensive screening study identifies optimal in vitro BBB membrane set points. ► Pore diameter, material, manufacturer and co-culture orientation are studied. ► Significant optimal set points are 0.4μm pore size, PET and non-contact orientation. ► Primary and immortalized murine brain endoth...

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Veröffentlicht in:	Journal of neuroscience methods 2013-01, Vol.212 (2), p.211-221
Hauptverfasser:	Wuest, Diane M., Wing, Allison M., Lee, Kelvin H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes Astrocytes - cytology bEnd.3 murine cell line Blood-Brain Barrier - cytology Blood-Brain Barrier - physiology Blood–brain barrier Cell Culture Techniques - methods Coculture Techniques Electric Impedance Endothelial Cells - cytology In vitro model Mice Models, Biological Murine brain microvascular endothelial cells Permeability Polycarboxylate Cement Polyethylene Terephthalates
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