Reduced MicroRNA-150 Is Associated with Poor Survival in Pulmonary Arterial Hypertension

MicroRNAs (miRNAs or miRs) are implicated in the pathogenesis of various cardiovascular diseases, including pulmonary arterial hypertension (PAH). We sought to measure changes in plasma levels of miRNAs in patients with PAH and relate them to the severity of the disease. A microarray screen was perf...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2013-02, Vol.187 (3), p.294-302
Hauptverfasser:	RHODES, Christopher J, WHARTON, John, CONDLIFFE, Robin, ELLIOT, Charles A, KIELY, David G, HUSON, Les, GHOFRANI, Hossein A, TIEDE, Henning, SCHERMULY, Ralph, ZEIHER, Andreas M, DIMMELER, Stefanie, WILKINS, Martin R, BOON, Reinier A, ROEXE, Tino, TSANG, Hilda, WOJCIAK-STOTHARD, Beata, CHAKRABARTI, Anob, HOWARD, Luke S, GIBBS, J. Simon R, LAWRIE, Allan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Distribution Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Biomarkers Biomarkers - blood Cardiovascular disease Cohort Studies Disease Models, Animal Down-Regulation Familial Primary Pulmonary Hypertension Female Humans Hypertension, Pulmonary - blood Hypertension, Pulmonary - genetics Intensive care medicine London Lungs Male Medical sciences Microarray Analysis - methods MicroRNAs MicroRNAs - blood Middle Aged Mortality Pathogenesis Patients Plasma Pneumology Polymerase Chain Reaction - methods Proteins Pulmonary arteries Pulmonary hypertension Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Rats ROC Curve Severity of Illness Index Survival Analysis
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