Serum S100B in patients with brain tumours undergoing craniotomy
To determine pre- and postoperative serum S100B concentrations in patients with intracranial tumours that underwent craniotomy and compare the values with healthy controls. An observational, comparative study. Neurosurgical Ward, Jinnah Postgraduate Medical Centre. Karachi, from May 2007 to April 20...
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| Veröffentlicht in: | Journal of the College of Physicians and Surgeons--Pakistan 2013-02, Vol.23 (2), p.112-115 |
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| creator | Syeda, Talat Muhammad Hashim, Abdul Sattar Rizvi, Husan Afroz Hadi, Syed Murtaza |
| description | To determine pre- and postoperative serum S100B concentrations in patients with intracranial tumours that underwent craniotomy and compare the values with healthy controls.
An observational, comparative study.
Neurosurgical Ward, Jinnah Postgraduate Medical Centre. Karachi, from May 2007 to April 2008.
Serum S100B was measured pre- and postoperatively on days 1, 2 and 7 in 18 healthy controls and similar number of patients who underwent craniotomy for intracranial tumours. Mean pre-operative patients and control values were compared using Mann-Whitney (unpaired) or Wilcoxon (paired) tests for comparing between pre- and postoperative values. The p-value was considered significant at < 0.05.
Serum S100B concentrations were significantly higher in patients with mean value of 0.19 ± 0.12 μg/L than in healthy controls (mean 0.03 ± 0.01, p < 0.0005). Significantly raised serum S100B concentrations were observed in all postoperative samples when compared with pre-operative samples. S100B concentrations significantly increased on postoperative day 1 (mean = 0.90 ± 1.07 μg/L, p < 0.0005), decreased on day 2 (mean = 0.84 ± 0.57 μg/L, p < 0.0005). The concentrations further declined on day 7 (mean = 0.44 ± 0.43 μg/L, p = 0.005).
The significantly high postoperative concentrations of S100B in patients appear as a consequence of tissue damage due to surgical procedures. The absence of fall of the S100B concentration in serum from the peak value on postoperative day 1 and day 2 could provide early warning of brain tissue damage leading to neurological deterioration. |
| format | Article |
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An observational, comparative study.
Neurosurgical Ward, Jinnah Postgraduate Medical Centre. Karachi, from May 2007 to April 2008.
Serum S100B was measured pre- and postoperatively on days 1, 2 and 7 in 18 healthy controls and similar number of patients who underwent craniotomy for intracranial tumours. Mean pre-operative patients and control values were compared using Mann-Whitney (unpaired) or Wilcoxon (paired) tests for comparing between pre- and postoperative values. The p-value was considered significant at < 0.05.
Serum S100B concentrations were significantly higher in patients with mean value of 0.19 ± 0.12 μg/L than in healthy controls (mean 0.03 ± 0.01, p < 0.0005). Significantly raised serum S100B concentrations were observed in all postoperative samples when compared with pre-operative samples. S100B concentrations significantly increased on postoperative day 1 (mean = 0.90 ± 1.07 μg/L, p < 0.0005), decreased on day 2 (mean = 0.84 ± 0.57 μg/L, p < 0.0005). The concentrations further declined on day 7 (mean = 0.44 ± 0.43 μg/L, p = 0.005).
The significantly high postoperative concentrations of S100B in patients appear as a consequence of tissue damage due to surgical procedures. The absence of fall of the S100B concentration in serum from the peak value on postoperative day 1 and day 2 could provide early warning of brain tissue damage leading to neurological deterioration.</description><identifier>ISSN: 1022-386X</identifier><identifier>EISSN: 1681-7168</identifier><identifier>PMID: 23374513</identifier><language>eng</language><publisher>Pakistan: College of Physicians and Surgeons Pakistan</publisher><subject>Adult ; Brain damage ; Brain Neoplasms - blood ; Brain Neoplasms - diagnosis ; Brain Neoplasms - surgery ; Calcium-binding proteins ; Care and treatment ; Case-Control Studies ; Complications and side effects ; Craniotomy ; Diagnosis ; Female ; Follow-Up Studies ; Health aspects ; Hospitals, University ; Humans ; Intracranial tumors ; Male ; Middle Aged ; Pakistan ; Postoperative Period ; Preoperative Period ; S100 Proteins - blood ; Socioeconomic Factors ; Time Factors ; Young Adult</subject><ispartof>Journal of the College of Physicians and Surgeons--Pakistan, 2013-02, Vol.23 (2), p.112-115</ispartof><rights>COPYRIGHT 2013 College of Physicians and Surgeons Pakistan</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23374513$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Syeda, Talat</creatorcontrib><creatorcontrib>Muhammad Hashim, Abdul Sattar</creatorcontrib><creatorcontrib>Rizvi, Husan Afroz</creatorcontrib><creatorcontrib>Hadi, Syed Murtaza</creatorcontrib><title>Serum S100B in patients with brain tumours undergoing craniotomy</title><title>Journal of the College of Physicians and Surgeons--Pakistan</title><addtitle>J Coll Physicians Surg Pak</addtitle><description>To determine pre- and postoperative serum S100B concentrations in patients with intracranial tumours that underwent craniotomy and compare the values with healthy controls.
An observational, comparative study.
Neurosurgical Ward, Jinnah Postgraduate Medical Centre. Karachi, from May 2007 to April 2008.
Serum S100B was measured pre- and postoperatively on days 1, 2 and 7 in 18 healthy controls and similar number of patients who underwent craniotomy for intracranial tumours. Mean pre-operative patients and control values were compared using Mann-Whitney (unpaired) or Wilcoxon (paired) tests for comparing between pre- and postoperative values. The p-value was considered significant at < 0.05.
Serum S100B concentrations were significantly higher in patients with mean value of 0.19 ± 0.12 μg/L than in healthy controls (mean 0.03 ± 0.01, p < 0.0005). Significantly raised serum S100B concentrations were observed in all postoperative samples when compared with pre-operative samples. S100B concentrations significantly increased on postoperative day 1 (mean = 0.90 ± 1.07 μg/L, p < 0.0005), decreased on day 2 (mean = 0.84 ± 0.57 μg/L, p < 0.0005). The concentrations further declined on day 7 (mean = 0.44 ± 0.43 μg/L, p = 0.005).
The significantly high postoperative concentrations of S100B in patients appear as a consequence of tissue damage due to surgical procedures. The absence of fall of the S100B concentration in serum from the peak value on postoperative day 1 and day 2 could provide early warning of brain tissue damage leading to neurological deterioration.</description><subject>Adult</subject><subject>Brain damage</subject><subject>Brain Neoplasms - blood</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - surgery</subject><subject>Calcium-binding proteins</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Complications and side effects</subject><subject>Craniotomy</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health aspects</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>Intracranial tumors</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pakistan</subject><subject>Postoperative Period</subject><subject>Preoperative Period</subject><subject>S100 Proteins - blood</subject><subject>Socioeconomic Factors</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>1022-386X</issn><issn>1681-7168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1LAzEQhhdRbK3-BQl48bKSj0023qylfkDBQxW8LUk2WSObpCZZpP_eLa0HQQZmXl6eeRnmqJgixlFZj_141BDjknD2PinOUvqEkFDE-WkxwYTUFUVkWtytdRwcWCMI74H1YCOy1T4n8G3zB5BRjF4eXBhiAoNvdeyC9R1QUXgbcnDb8-LEiD7pi8OcFW8Py9fFU7l6eXxezFdlh2ueS84gNsgwRJFCpqICc6oox0ZL2moJDb3VVS0rw1hlFOZEIKm4JC2pBCOEkllxvc_dxPA16JQbZ5PSfS-8DkNqEOYV5ozwekSv9mgnet1Yb0KOQu3wZk4QZ7hmcBd48w81VqudVcFrY0f_z8Ll4YJBOt02m2idiNvm95nkB0evbuU</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Syeda, Talat</creator><creator>Muhammad Hashim, Abdul Sattar</creator><creator>Rizvi, Husan Afroz</creator><creator>Hadi, Syed Murtaza</creator><general>College of Physicians and Surgeons Pakistan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20130201</creationdate><title>Serum S100B in patients with brain tumours undergoing craniotomy</title><author>Syeda, Talat ; Muhammad Hashim, Abdul Sattar ; Rizvi, Husan Afroz ; Hadi, Syed Murtaza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g278t-8602f1f6151c1f45a285c582feb5deb0f59e47b4f664fc283a1bc8b3d34a63353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Brain damage</topic><topic>Brain Neoplasms - blood</topic><topic>Brain Neoplasms - diagnosis</topic><topic>Brain Neoplasms - surgery</topic><topic>Calcium-binding proteins</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Complications and side effects</topic><topic>Craniotomy</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Health aspects</topic><topic>Hospitals, University</topic><topic>Humans</topic><topic>Intracranial tumors</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pakistan</topic><topic>Postoperative Period</topic><topic>Preoperative Period</topic><topic>S100 Proteins - blood</topic><topic>Socioeconomic Factors</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Syeda, Talat</creatorcontrib><creatorcontrib>Muhammad Hashim, Abdul Sattar</creatorcontrib><creatorcontrib>Rizvi, Husan Afroz</creatorcontrib><creatorcontrib>Hadi, Syed Murtaza</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the College of Physicians and Surgeons--Pakistan</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Syeda, Talat</au><au>Muhammad Hashim, Abdul Sattar</au><au>Rizvi, Husan Afroz</au><au>Hadi, Syed Murtaza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum S100B in patients with brain tumours undergoing craniotomy</atitle><jtitle>Journal of the College of Physicians and Surgeons--Pakistan</jtitle><addtitle>J Coll Physicians Surg Pak</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>23</volume><issue>2</issue><spage>112</spage><epage>115</epage><pages>112-115</pages><issn>1022-386X</issn><eissn>1681-7168</eissn><abstract>To determine pre- and postoperative serum S100B concentrations in patients with intracranial tumours that underwent craniotomy and compare the values with healthy controls.
An observational, comparative study.
Neurosurgical Ward, Jinnah Postgraduate Medical Centre. Karachi, from May 2007 to April 2008.
Serum S100B was measured pre- and postoperatively on days 1, 2 and 7 in 18 healthy controls and similar number of patients who underwent craniotomy for intracranial tumours. Mean pre-operative patients and control values were compared using Mann-Whitney (unpaired) or Wilcoxon (paired) tests for comparing between pre- and postoperative values. The p-value was considered significant at < 0.05.
Serum S100B concentrations were significantly higher in patients with mean value of 0.19 ± 0.12 μg/L than in healthy controls (mean 0.03 ± 0.01, p < 0.0005). Significantly raised serum S100B concentrations were observed in all postoperative samples when compared with pre-operative samples. S100B concentrations significantly increased on postoperative day 1 (mean = 0.90 ± 1.07 μg/L, p < 0.0005), decreased on day 2 (mean = 0.84 ± 0.57 μg/L, p < 0.0005). The concentrations further declined on day 7 (mean = 0.44 ± 0.43 μg/L, p = 0.005).
The significantly high postoperative concentrations of S100B in patients appear as a consequence of tissue damage due to surgical procedures. The absence of fall of the S100B concentration in serum from the peak value on postoperative day 1 and day 2 could provide early warning of brain tissue damage leading to neurological deterioration.</abstract><cop>Pakistan</cop><pub>College of Physicians and Surgeons Pakistan</pub><pmid>23374513</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Journal of the College of Physicians and Surgeons--Pakistan, 2013-02, Vol.23 (2), p.112-115 |
| issn | 1022-386X 1681-7168 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Brain damage Brain Neoplasms - blood Brain Neoplasms - diagnosis Brain Neoplasms - surgery Calcium-binding proteins Care and treatment Case-Control Studies Complications and side effects Craniotomy Diagnosis Female Follow-Up Studies Health aspects Hospitals, University Humans Intracranial tumors Male Middle Aged Pakistan Postoperative Period Preoperative Period S100 Proteins - blood Socioeconomic Factors Time Factors Young Adult |
| title | Serum S100B in patients with brain tumours undergoing craniotomy |
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