Role of Rac1 GTPase in salt-sensitive hypertension

PURPOSE OF REVIEWThe aldosterone/mineralocorticoid receptor system plays an important role in the long-term blood pressure control through Na homeostasis. Its overactivation has been implicated in salt-sensitive hypertension. Excessive salt intake augments the function of mineralocorticoid receptor,...

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Veröffentlicht in:	Current opinion in nephrology and hypertension 2013-03, Vol.22 (2), p.148-155
1. Verfasser:	Nagase, Miki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure Guanine Nucleotide Exchange Factors - metabolism Humans Hypertension - enzymology Hypertension - etiology Hypertension - genetics Hypertension - pathology Hypertension - physiopathology Kidney - enzymology Kidney - pathology Kidney - physiopathology Ligands rac1 GTP-Binding Protein - genetics rac1 GTP-Binding Protein - metabolism Rats Rats, Inbred Dahl Receptors, Mineralocorticoid - metabolism Signal Transduction Sodium Chloride, Dietary - adverse effects Sodium Chloride, Dietary - metabolism
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