The effect of purmorphamine and sirolimus on osteogenic differentiation of human bone marrow-derived mesenchymal stem cells

Abstract Small molecules have been introduced as less expensive biologically active compounds that can regulate different developmental phenomena. Purmorphamine and sirolimus are two small molecules that, according to some studies, possess certain osteomodulatory effects. This study was set out to h...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2013-02, Vol.67 (1), p.31-38
Hauptverfasser:	Faghihi, F, Baghaban Eslaminejad, M, Nekookar, A, Najar, M, Salekdeh, G.H
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - metabolism Animals Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Cell Differentiation - drug effects Dose-Response Relationship, Drug Human mesenchymal stem cells Humans Internal Medicine Male Medical Education Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Morpholines - administration & dosage Morpholines - pharmacology Osteoblasts - metabolism Osteogenesis - drug effects Osteogenic differentiation Purines - administration & dosage Purines - pharmacology Purmorphamine Rats Rats, Wistar Real-Time Polymerase Chain Reaction Sirolimus Sirolimus - administration & dosage Sirolimus - pharmacology Small molecules Time Factors
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