Susceptibility to chronic hepatitis C virus infection is influenced by sequence differences in immunodominant CD8+ T cell epitopes

Background & Aims The antiviral immune response against HCV by CD8+ T cells plays a central role in viral containment. In a large HCV genotype 1b outbreak in Ireland, HLA-B∗ 08 was identified as a risk allele for chronic infection and HLA-A∗ 03 and HLA-B∗ 27 were associated with higher clearance...

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Veröffentlicht in:	Journal of hepatology 2013-01, Vol.58 (1), p.24-30
Hauptverfasser:	Ziegler, Susanne, Ruhl, Marianne, Tenckhoff, Hannelore, Wiese, Manfred, Heinemann, Falko M, Horn, Peter A, Spengler, Ulrich, Neumann-Haefelin, Christoph, Nattermann, Jacob, Timm, Jörg
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-D CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - virology Disease Outbreaks - statistics & numerical data Disease Susceptibility - epidemiology Disease Susceptibility - immunology Epitopes, T-Lymphocyte - immunology Gastroenterology and Hepatology Genotype Germany - epidemiology Hepatitis C, Chronic - epidemiology Hepatitis C, Chronic - immunology HLA class I HLA-A3 Antigen - genetics HLA-B Antigens - genetics HLA-B27 Antigen - genetics HLA-B8 Antigen - genetics Humans IL28B Immune escape Immunodominant Epitopes - immunology Ireland - epidemiology Risk Factors Selection
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