Genistein Inhibits ox-LDL-induced VCAM-1, ICAM-1 and MCP-1 Expression of HUVECs Through Heme Oxygenase-1

Background and Aims Genistein, a principal component of soybean isoflavones, plays an important role in the prevention of atherosclerosis. However, the detailed mechanisms have not been fully investigated. The aims of this study were to evaluate the anti-atherosclerotic effect and investigate potent...

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Veröffentlicht in:	Archives of medical research 2013, Vol.44 (1), p.13-20
Hauptverfasser:	Zhang, Hua-ping, Zheng, Feng-li, Zhao, Jia-hui, Guo, Dong-xing, Chen, Xiao-long
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis Cell Nucleus - drug effects Cell Nucleus - metabolism Cell Survival - drug effects Chemokine CCL2 - biosynthesis Chemokine CCL2 - genetics Chemokine CCL2 - secretion Down-Regulation - drug effects Genistein Genistein - pharmacology Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism HO-1 Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - enzymology Human Umbilical Vein Endothelial Cells - metabolism Humans Inflammation Intercellular Adhesion Molecule-1 - biosynthesis Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - metabolism Internal Medicine Lipoproteins, LDL - pharmacology NF-E2-Related Factor 2 - metabolism Nrf2 RNA, Messenger - genetics RNA, Messenger - metabolism Vascular Cell Adhesion Molecule-1 - biosynthesis Vascular Cell Adhesion Molecule-1 - genetics Vascular Cell Adhesion Molecule-1 - metabolism
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