Development of a Gold-Multifaceted Catalysis Approach to the Synthesis of Highly Substituted Pyrroles: Mechanistic Insights via Huisgen Cycloaddition Studies

A novel gold-catalyzed method for the regioselective synthesis of highly substituted pyrroles directly from oximes and alkynes was developed via independent optimization of two key steps of the process. Importantly, a cationic gold(I) species was shown to activate multiple steps along the reaction p...

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Veröffentlicht in:	Journal of organic chemistry 2013-02, Vol.78 (3), p.920-934
Hauptverfasser:	Ngwerume, Simbarashe, Lewis, William, Camp, Jason E
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Catalysis Cycloaddition Reaction Gold - chemistry Ketones - chemistry Oximes - chemistry Pyrroles - chemical synthesis Pyrroles - chemistry Stereoisomerism
Online-Zugang:	Volltext
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