Sentinel Lymph Node Biopsy for Melanoma in Pregnant Women
Background The incidence of melanoma is rising in young women of childbearing age. Melanoma diagnosed during pregnancy presents unique challenges. This study was conducted to determine the effect of sentinel lymph node biopsy (SLNB) for melanoma on maternal and fetal outcomes in pregnant women. Meth...
Gespeichert in:
| Veröffentlicht in: | Annals of surgical oncology 2013-02, Vol.20 (2), p.689-696 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 696 |
|---|---|
| container_issue | 2 |
| container_start_page | 689 |
| container_title | Annals of surgical oncology |
| container_volume | 20 |
| creator | Andtbacka, Robert H. I. Donaldson, Matthew R. Bowles, Tawnya L. Bowen, Glen M. Grossmann, Kenneth Khong, Hung Grossman, Douglas Anker, Christopher Florell, Scott R. Bowen, Anneli Duffy, Keith L. Leachman, Sancy A. Noyes, R. Dirk |
| description | Background
The incidence of melanoma is rising in young women of childbearing age. Melanoma diagnosed during pregnancy presents unique challenges. This study was conducted to determine the effect of sentinel lymph node biopsy (SLNB) for melanoma on maternal and fetal outcomes in pregnant women.
Methods
A prospective melanoma database was retrospectively queried for women diagnosed with melanoma during or immediately before pregnancy as well as SLNB in pregnant women. The outcomes of SLNB for the mothers and fetuses were evaluated.
Results
Fifteen pregnant women underwent wide local excision (WLE) and SLNB for melanoma from 1997 to 2012. The median gestational age was 20 weeks. More than half of the women noticed changes in the primary melanoma lesion during the pregnancy. The median Breslow thickness was 1.00 mm. Lymphatic mapping and SLNB were performed with some combination of radiocolloid or vital blue dye without adverse effects. Three patients had micrometastatic disease and underwent a completion lymphadenectomy. Sixteen children were born at a median gestational age of 39 weeks. The median 1- and 5-minute Apgar scores were 8 and 9, respectively. At a median follow-up of 54.4, months none of the patients had experienced recurrence, and all children were healthy and free of melanoma.
Conclusions
In this series of pregnant women with melanoma, SLNB was performed safely during pregnancy without adverse effects to the mothers and fetuses. We recommend that clinicians explain the risks and benefits of the SLNB procedure to pregnant women so an informed decision can be made about the procedure. |
| doi_str_mv | 10.1245/s10434-012-2633-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1283728310</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1283728310</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-388bc8a0b4473cd88b4f3032272f9318c9701df6913ddda5ee19a86d287226d3</originalsourceid><addsrcrecordid>eNp1kMtOwzAQRS0EolD4ADYoEhs2AY_tOPYSKl5SeUhUYmmlsVNSJXaxk0X_HpcUhJBYjR9n7owOQieAL4Cw7DIAZpSlGEhKOKVpvoMOIIsvjAvYjWfMRSoJz0boMIQlxpBTnO2jEYmFAcABkq_GdrU1TTJdt6v35Mlpk1zXbhXWSeV88miawrq2SGqbvHizsIXtkjfXGnuE9qqiCeZ4W8dodnszm9yn0-e7h8nVNC1pTrqUCjEvRYHnjOW01PHGKoopITmpJAVRyhyDrrgEqrUuMmNAFoJrInJCuKZjdD7Errz76E3oVFuH0jRxLeP6oICIOEdQwBE9-4MuXe9tXO6LAiolZ5GCgSq9C8GbSq183RZ-rQCrjVY1aFVRq9poVXnsOd0m9_PW6J-Ob48RIAMQ4pddGP9r9L-pnzywf3I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1283139964</pqid></control><display><type>article</type><title>Sentinel Lymph Node Biopsy for Melanoma in Pregnant Women</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Andtbacka, Robert H. I. ; Donaldson, Matthew R. ; Bowles, Tawnya L. ; Bowen, Glen M. ; Grossmann, Kenneth ; Khong, Hung ; Grossman, Douglas ; Anker, Christopher ; Florell, Scott R. ; Bowen, Anneli ; Duffy, Keith L. ; Leachman, Sancy A. ; Noyes, R. Dirk</creator><creatorcontrib>Andtbacka, Robert H. I. ; Donaldson, Matthew R. ; Bowles, Tawnya L. ; Bowen, Glen M. ; Grossmann, Kenneth ; Khong, Hung ; Grossman, Douglas ; Anker, Christopher ; Florell, Scott R. ; Bowen, Anneli ; Duffy, Keith L. ; Leachman, Sancy A. ; Noyes, R. Dirk</creatorcontrib><description>Background
The incidence of melanoma is rising in young women of childbearing age. Melanoma diagnosed during pregnancy presents unique challenges. This study was conducted to determine the effect of sentinel lymph node biopsy (SLNB) for melanoma on maternal and fetal outcomes in pregnant women.
Methods
A prospective melanoma database was retrospectively queried for women diagnosed with melanoma during or immediately before pregnancy as well as SLNB in pregnant women. The outcomes of SLNB for the mothers and fetuses were evaluated.
Results
Fifteen pregnant women underwent wide local excision (WLE) and SLNB for melanoma from 1997 to 2012. The median gestational age was 20 weeks. More than half of the women noticed changes in the primary melanoma lesion during the pregnancy. The median Breslow thickness was 1.00 mm. Lymphatic mapping and SLNB were performed with some combination of radiocolloid or vital blue dye without adverse effects. Three patients had micrometastatic disease and underwent a completion lymphadenectomy. Sixteen children were born at a median gestational age of 39 weeks. The median 1- and 5-minute Apgar scores were 8 and 9, respectively. At a median follow-up of 54.4, months none of the patients had experienced recurrence, and all children were healthy and free of melanoma.
Conclusions
In this series of pregnant women with melanoma, SLNB was performed safely during pregnancy without adverse effects to the mothers and fetuses. We recommend that clinicians explain the risks and benefits of the SLNB procedure to pregnant women so an informed decision can be made about the procedure.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-012-2633-7</identifier><identifier>PMID: 23054111</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adult ; Female ; Fetus - pathology ; Follow-Up Studies ; Gestational Age ; Humans ; Medicine ; Medicine & Public Health ; Melanoma - pathology ; Melanoma - surgery ; Melanomas ; Neoplasm Staging ; Oncology ; Postoperative Complications ; Pregnancy ; Pregnancy Complications, Neoplastic - pathology ; Pregnancy Complications, Neoplastic - surgery ; Pregnancy Outcome ; Prospective Studies ; Retrospective Studies ; Sentinel Lymph Node Biopsy - adverse effects ; Skin Neoplasms - pathology ; Skin Neoplasms - surgery ; Surgery ; Surgical Oncology ; Young Adult</subject><ispartof>Annals of surgical oncology, 2013-02, Vol.20 (2), p.689-696</ispartof><rights>Society of Surgical Oncology 2012</rights><rights>Society of Surgical Oncology 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-388bc8a0b4473cd88b4f3032272f9318c9701df6913ddda5ee19a86d287226d3</citedby><cites>FETCH-LOGICAL-c372t-388bc8a0b4473cd88b4f3032272f9318c9701df6913ddda5ee19a86d287226d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-012-2633-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-012-2633-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23054111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andtbacka, Robert H. I.</creatorcontrib><creatorcontrib>Donaldson, Matthew R.</creatorcontrib><creatorcontrib>Bowles, Tawnya L.</creatorcontrib><creatorcontrib>Bowen, Glen M.</creatorcontrib><creatorcontrib>Grossmann, Kenneth</creatorcontrib><creatorcontrib>Khong, Hung</creatorcontrib><creatorcontrib>Grossman, Douglas</creatorcontrib><creatorcontrib>Anker, Christopher</creatorcontrib><creatorcontrib>Florell, Scott R.</creatorcontrib><creatorcontrib>Bowen, Anneli</creatorcontrib><creatorcontrib>Duffy, Keith L.</creatorcontrib><creatorcontrib>Leachman, Sancy A.</creatorcontrib><creatorcontrib>Noyes, R. Dirk</creatorcontrib><title>Sentinel Lymph Node Biopsy for Melanoma in Pregnant Women</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
The incidence of melanoma is rising in young women of childbearing age. Melanoma diagnosed during pregnancy presents unique challenges. This study was conducted to determine the effect of sentinel lymph node biopsy (SLNB) for melanoma on maternal and fetal outcomes in pregnant women.
Methods
A prospective melanoma database was retrospectively queried for women diagnosed with melanoma during or immediately before pregnancy as well as SLNB in pregnant women. The outcomes of SLNB for the mothers and fetuses were evaluated.
Results
Fifteen pregnant women underwent wide local excision (WLE) and SLNB for melanoma from 1997 to 2012. The median gestational age was 20 weeks. More than half of the women noticed changes in the primary melanoma lesion during the pregnancy. The median Breslow thickness was 1.00 mm. Lymphatic mapping and SLNB were performed with some combination of radiocolloid or vital blue dye without adverse effects. Three patients had micrometastatic disease and underwent a completion lymphadenectomy. Sixteen children were born at a median gestational age of 39 weeks. The median 1- and 5-minute Apgar scores were 8 and 9, respectively. At a median follow-up of 54.4, months none of the patients had experienced recurrence, and all children were healthy and free of melanoma.
Conclusions
In this series of pregnant women with melanoma, SLNB was performed safely during pregnancy without adverse effects to the mothers and fetuses. We recommend that clinicians explain the risks and benefits of the SLNB procedure to pregnant women so an informed decision can be made about the procedure.</description><subject>Adult</subject><subject>Female</subject><subject>Fetus - pathology</subject><subject>Follow-Up Studies</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Melanoma - pathology</subject><subject>Melanoma - surgery</subject><subject>Melanomas</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Postoperative Complications</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Neoplastic - pathology</subject><subject>Pregnancy Complications, Neoplastic - surgery</subject><subject>Pregnancy Outcome</subject><subject>Prospective Studies</subject><subject>Retrospective Studies</subject><subject>Sentinel Lymph Node Biopsy - adverse effects</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - surgery</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Young Adult</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kMtOwzAQRS0EolD4ADYoEhs2AY_tOPYSKl5SeUhUYmmlsVNSJXaxk0X_HpcUhJBYjR9n7owOQieAL4Cw7DIAZpSlGEhKOKVpvoMOIIsvjAvYjWfMRSoJz0boMIQlxpBTnO2jEYmFAcABkq_GdrU1TTJdt6v35Mlpk1zXbhXWSeV88miawrq2SGqbvHizsIXtkjfXGnuE9qqiCeZ4W8dodnszm9yn0-e7h8nVNC1pTrqUCjEvRYHnjOW01PHGKoopITmpJAVRyhyDrrgEqrUuMmNAFoJrInJCuKZjdD7Errz76E3oVFuH0jRxLeP6oICIOEdQwBE9-4MuXe9tXO6LAiolZ5GCgSq9C8GbSq183RZ-rQCrjVY1aFVRq9poVXnsOd0m9_PW6J-Ob48RIAMQ4pddGP9r9L-pnzywf3I</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Andtbacka, Robert H. I.</creator><creator>Donaldson, Matthew R.</creator><creator>Bowles, Tawnya L.</creator><creator>Bowen, Glen M.</creator><creator>Grossmann, Kenneth</creator><creator>Khong, Hung</creator><creator>Grossman, Douglas</creator><creator>Anker, Christopher</creator><creator>Florell, Scott R.</creator><creator>Bowen, Anneli</creator><creator>Duffy, Keith L.</creator><creator>Leachman, Sancy A.</creator><creator>Noyes, R. Dirk</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130201</creationdate><title>Sentinel Lymph Node Biopsy for Melanoma in Pregnant Women</title><author>Andtbacka, Robert H. I. ; Donaldson, Matthew R. ; Bowles, Tawnya L. ; Bowen, Glen M. ; Grossmann, Kenneth ; Khong, Hung ; Grossman, Douglas ; Anker, Christopher ; Florell, Scott R. ; Bowen, Anneli ; Duffy, Keith L. ; Leachman, Sancy A. ; Noyes, R. Dirk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-388bc8a0b4473cd88b4f3032272f9318c9701df6913ddda5ee19a86d287226d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Female</topic><topic>Fetus - pathology</topic><topic>Follow-Up Studies</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Melanoma - pathology</topic><topic>Melanoma - surgery</topic><topic>Melanomas</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Postoperative Complications</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Neoplastic - pathology</topic><topic>Pregnancy Complications, Neoplastic - surgery</topic><topic>Pregnancy Outcome</topic><topic>Prospective Studies</topic><topic>Retrospective Studies</topic><topic>Sentinel Lymph Node Biopsy - adverse effects</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - surgery</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andtbacka, Robert H. I.</creatorcontrib><creatorcontrib>Donaldson, Matthew R.</creatorcontrib><creatorcontrib>Bowles, Tawnya L.</creatorcontrib><creatorcontrib>Bowen, Glen M.</creatorcontrib><creatorcontrib>Grossmann, Kenneth</creatorcontrib><creatorcontrib>Khong, Hung</creatorcontrib><creatorcontrib>Grossman, Douglas</creatorcontrib><creatorcontrib>Anker, Christopher</creatorcontrib><creatorcontrib>Florell, Scott R.</creatorcontrib><creatorcontrib>Bowen, Anneli</creatorcontrib><creatorcontrib>Duffy, Keith L.</creatorcontrib><creatorcontrib>Leachman, Sancy A.</creatorcontrib><creatorcontrib>Noyes, R. Dirk</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andtbacka, Robert H. I.</au><au>Donaldson, Matthew R.</au><au>Bowles, Tawnya L.</au><au>Bowen, Glen M.</au><au>Grossmann, Kenneth</au><au>Khong, Hung</au><au>Grossman, Douglas</au><au>Anker, Christopher</au><au>Florell, Scott R.</au><au>Bowen, Anneli</au><au>Duffy, Keith L.</au><au>Leachman, Sancy A.</au><au>Noyes, R. Dirk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sentinel Lymph Node Biopsy for Melanoma in Pregnant Women</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>20</volume><issue>2</issue><spage>689</spage><epage>696</epage><pages>689-696</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
The incidence of melanoma is rising in young women of childbearing age. Melanoma diagnosed during pregnancy presents unique challenges. This study was conducted to determine the effect of sentinel lymph node biopsy (SLNB) for melanoma on maternal and fetal outcomes in pregnant women.
Methods
A prospective melanoma database was retrospectively queried for women diagnosed with melanoma during or immediately before pregnancy as well as SLNB in pregnant women. The outcomes of SLNB for the mothers and fetuses were evaluated.
Results
Fifteen pregnant women underwent wide local excision (WLE) and SLNB for melanoma from 1997 to 2012. The median gestational age was 20 weeks. More than half of the women noticed changes in the primary melanoma lesion during the pregnancy. The median Breslow thickness was 1.00 mm. Lymphatic mapping and SLNB were performed with some combination of radiocolloid or vital blue dye without adverse effects. Three patients had micrometastatic disease and underwent a completion lymphadenectomy. Sixteen children were born at a median gestational age of 39 weeks. The median 1- and 5-minute Apgar scores were 8 and 9, respectively. At a median follow-up of 54.4, months none of the patients had experienced recurrence, and all children were healthy and free of melanoma.
Conclusions
In this series of pregnant women with melanoma, SLNB was performed safely during pregnancy without adverse effects to the mothers and fetuses. We recommend that clinicians explain the risks and benefits of the SLNB procedure to pregnant women so an informed decision can be made about the procedure.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>23054111</pmid><doi>10.1245/s10434-012-2633-7</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2013-02, Vol.20 (2), p.689-696 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1283728310 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Female Fetus - pathology Follow-Up Studies Gestational Age Humans Medicine Medicine & Public Health Melanoma - pathology Melanoma - surgery Melanomas Neoplasm Staging Oncology Postoperative Complications Pregnancy Pregnancy Complications, Neoplastic - pathology Pregnancy Complications, Neoplastic - surgery Pregnancy Outcome Prospective Studies Retrospective Studies Sentinel Lymph Node Biopsy - adverse effects Skin Neoplasms - pathology Skin Neoplasms - surgery Surgery Surgical Oncology Young Adult |
| title | Sentinel Lymph Node Biopsy for Melanoma in Pregnant Women |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T04%3A28%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sentinel%20Lymph%20Node%20Biopsy%20for%20Melanoma%20in%20Pregnant%20Women&rft.jtitle=Annals%20of%20surgical%20oncology&rft.au=Andtbacka,%20Robert%20H.%20I.&rft.date=2013-02-01&rft.volume=20&rft.issue=2&rft.spage=689&rft.epage=696&rft.pages=689-696&rft.issn=1068-9265&rft.eissn=1534-4681&rft_id=info:doi/10.1245/s10434-012-2633-7&rft_dat=%3Cproquest_cross%3E1283728310%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1283139964&rft_id=info:pmid/23054111&rfr_iscdi=true |