Clinical Significance of Lymph Node Micrometastasis in Gastric Cancer
Recently, the existence of lymph node micrometastasis (LNM), including isolated tumor cells, has been focused on during the development of molecular diagnostic tools for lymph node metastasis in various malignant neoplasms. In particular, immunohistochemistry and reverse transcription-polymerase cha...
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| Veröffentlicht in: | Annals of surgical oncology 2013-02, Vol.20 (2), p.515-521 |
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| container_title | Annals of surgical oncology |
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| creator | Arigami, Takaaki Uenosono, Yoshikazu Yanagita, Shigehiro Nakajo, Akihiro Ishigami, Sumiya Okumura, Hiroshi Kijima, Yuko Ueno, Shinichi Natsugoe, Shoji |
| description | Recently, the existence of lymph node micrometastasis (LNM), including isolated tumor cells, has been focused on during the development of molecular diagnostic tools for lymph node metastasis in various malignant neoplasms. In particular, immunohistochemistry and reverse transcription-polymerase chain reaction have been reported to be available for the detection of LNM in gastric cancer. However, at present, the clinical significance of LNM remains unclear in patients with gastric cancer. Therefore, we cannot strategically make light of this issue in clinical management. Currently, minimally invasive treatments, such as endoscopic submucosal dissection and laparoscopic surgery with personalized lymphadenectomy, are widely performed in consideration of postsurgical quality of life (QOL). However, it is important to maintain the balance between QOL and curability when selecting surgical treatments for patients with gastric cancer. If minimally invasive surgery based on LNM status was established for patients with early gastric cancer, it could be performed safely. We reviewed the clinical significance of LNM as an important strategic target in patients with gastric cancer. |
| doi_str_mv | 10.1245/s10434-012-2355-x |
| format | Article |
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In particular, immunohistochemistry and reverse transcription-polymerase chain reaction have been reported to be available for the detection of LNM in gastric cancer. However, at present, the clinical significance of LNM remains unclear in patients with gastric cancer. Therefore, we cannot strategically make light of this issue in clinical management. Currently, minimally invasive treatments, such as endoscopic submucosal dissection and laparoscopic surgery with personalized lymphadenectomy, are widely performed in consideration of postsurgical quality of life (QOL). However, it is important to maintain the balance between QOL and curability when selecting surgical treatments for patients with gastric cancer. If minimally invasive surgery based on LNM status was established for patients with early gastric cancer, it could be performed safely. We reviewed the clinical significance of LNM as an important strategic target in patients with gastric cancer.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-012-2355-x</identifier><identifier>PMID: 22546997</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Gastrointestinal Oncology ; Humans ; Lymphatic Metastasis ; Medicine ; Medicine & Public Health ; Neoplasm Micrometastasis ; Oncology ; Prognosis ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Surgery ; Surgical Oncology</subject><ispartof>Annals of surgical oncology, 2013-02, Vol.20 (2), p.515-521</ispartof><rights>Society of Surgical Oncology 2012</rights><rights>Society of Surgical Oncology 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-c182c40c04079b71214a82dca93547ef51c7c71c7d384d4c13ea13be49fcb3d83</citedby><cites>FETCH-LOGICAL-c438t-c182c40c04079b71214a82dca93547ef51c7c71c7d384d4c13ea13be49fcb3d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-012-2355-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-012-2355-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22546997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arigami, Takaaki</creatorcontrib><creatorcontrib>Uenosono, Yoshikazu</creatorcontrib><creatorcontrib>Yanagita, Shigehiro</creatorcontrib><creatorcontrib>Nakajo, Akihiro</creatorcontrib><creatorcontrib>Ishigami, Sumiya</creatorcontrib><creatorcontrib>Okumura, Hiroshi</creatorcontrib><creatorcontrib>Kijima, Yuko</creatorcontrib><creatorcontrib>Ueno, Shinichi</creatorcontrib><creatorcontrib>Natsugoe, Shoji</creatorcontrib><title>Clinical Significance of Lymph Node Micrometastasis in Gastric Cancer</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Recently, the existence of lymph node micrometastasis (LNM), including isolated tumor cells, has been focused on during the development of molecular diagnostic tools for lymph node metastasis in various malignant neoplasms. 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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Gastrointestinal Oncology Humans Lymphatic Metastasis Medicine Medicine & Public Health Neoplasm Micrometastasis Oncology Prognosis Stomach Neoplasms - pathology Stomach Neoplasms - surgery Surgery Surgical Oncology |
| title | Clinical Significance of Lymph Node Micrometastasis in Gastric Cancer |
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