Factors affecting left ventricular synchronicity in hypertensive patients: are arterial stiffness and central blood pressures influential?
Left ventricular (LV) dyssynchrony is a common finding in patients with hypertension and is associated with LV hypertrophy. Arterial stiffness (AS) and central (aortic) blood pressures play a significant role in end-organ damage such as LV hypertrophy caused by hypertension. The objective of this st...
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| Veröffentlicht in: | Türk Kardiyoloji Derneği arşivi 2012-10, Vol.40 (7), p.581-588 |
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| container_title | Türk Kardiyoloji Derneği arşivi |
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| creator | Kırış, Abdulkadir Kırış, Gülhanım Karaman, Kayıhan Sahin, Mürsel Gedikli, Omer Kaplan, Sahin Orem, Asım Kutlu, Merih Kazaz, Zeynep |
| description | Left ventricular (LV) dyssynchrony is a common finding in patients with hypertension and is associated with LV hypertrophy. Arterial stiffness (AS) and central (aortic) blood pressures play a significant role in end-organ damage such as LV hypertrophy caused by hypertension. The objective of this study was to investigate the relationship between AS, central blood pressures (BP) and LV dyssynchrony.
Thirty-five newly diagnosed hypertensive patients and 40 controls were enrolled in the study. The entire study population underwent a comprehensive echocardiographic study including tissue synchrony imaging. The 12 segmental model was used to measure the time to regional peak systolic tissue velocity (Ts) in the LV and two dyssynchrony indices were computed. Parameters of AS including pulse wave velocity (PWV), augmentation index (AIx@75), and central systolic and diastolic BP were evaluated by applanation tonometry.
The baseline clinical and echocardiographic parameters of both groups were similar except for their BPs. Dyssynchrony indices were prolonged in patients with hypertension as compared to the controls. The standart deviation of Ts of 12 LV segments in patients with hypertension and the controls were 48.7±18.8 vs. 25.8±13.1, respectively (p |
| doi_str_mv | 10.5543/tkda.2012.27474 |
| format | Article |
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Thirty-five newly diagnosed hypertensive patients and 40 controls were enrolled in the study. The entire study population underwent a comprehensive echocardiographic study including tissue synchrony imaging. The 12 segmental model was used to measure the time to regional peak systolic tissue velocity (Ts) in the LV and two dyssynchrony indices were computed. Parameters of AS including pulse wave velocity (PWV), augmentation index (AIx@75), and central systolic and diastolic BP were evaluated by applanation tonometry.
The baseline clinical and echocardiographic parameters of both groups were similar except for their BPs. Dyssynchrony indices were prolonged in patients with hypertension as compared to the controls. The standart deviation of Ts of 12 LV segments in patients with hypertension and the controls were 48.7±18.8 vs. 25.8±13.1, respectively (p<0.001), and the maximal difference in Ts between any 2 of 12 LV segments was 143.9±52.2 for hypertension patients vs. 83.8±39.4 for controls (p<0.001). PWV (11.9±2.5 vs. 9.5±1.4, p<0.001), AIx@75 (27.4±8.3 vs. 18.3±9, p=0.009), and central systolic (147.6±20.8 vs. 105.4±11, p<0.001) and diastolic (99.8±14.4 vs. 72.8±9.5, p<0.001) pressures were higher in patients with hypertension than in the controls, respectively. In multivariable analysis, central systolic BP (ß=0.496, p=0.03), LV mass index (ß=0.232, p=0.027), and body mass index (ß=0.308, p=0.002) were found to be independently related to dyssynchrony.
Central systolic BP is an independent predictor of LV dyssynchrony, but Aıx@75 did not have an independent effect on LV synchronicity in patients with newly-diagnosed hypertension.</description><identifier>ISSN: 1016-5169</identifier><identifier>DOI: 10.5543/tkda.2012.27474</identifier><identifier>PMID: 23363940</identifier><language>eng</language><publisher>Turkey</publisher><subject>Adult ; Aorta - physiology ; Blood Pressure - physiology ; Case-Control Studies ; Echocardiography - methods ; Electrocardiography ; Female ; Heart Ventricles - physiopathology ; Humans ; Hypertension - complications ; Hypertension - physiopathology ; Hypertrophy, Left Ventricular - complications ; Hypertrophy, Left Ventricular - physiopathology ; Male ; Middle Aged ; Obesity - complications ; Pulse Wave Analysis ; Vascular Stiffness - physiology</subject><ispartof>Türk Kardiyoloji Derneği arşivi, 2012-10, Vol.40 (7), p.581-588</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-4858eede0d87558eed9dd5907bb2a5f875ca2a2f2afa680d136ec601e70760a33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23363940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kırış, Abdulkadir</creatorcontrib><creatorcontrib>Kırış, Gülhanım</creatorcontrib><creatorcontrib>Karaman, Kayıhan</creatorcontrib><creatorcontrib>Sahin, Mürsel</creatorcontrib><creatorcontrib>Gedikli, Omer</creatorcontrib><creatorcontrib>Kaplan, Sahin</creatorcontrib><creatorcontrib>Orem, Asım</creatorcontrib><creatorcontrib>Kutlu, Merih</creatorcontrib><creatorcontrib>Kazaz, Zeynep</creatorcontrib><title>Factors affecting left ventricular synchronicity in hypertensive patients: are arterial stiffness and central blood pressures influential?</title><title>Türk Kardiyoloji Derneği arşivi</title><addtitle>Turk Kardiyol Dern Ars</addtitle><description>Left ventricular (LV) dyssynchrony is a common finding in patients with hypertension and is associated with LV hypertrophy. Arterial stiffness (AS) and central (aortic) blood pressures play a significant role in end-organ damage such as LV hypertrophy caused by hypertension. The objective of this study was to investigate the relationship between AS, central blood pressures (BP) and LV dyssynchrony.
Thirty-five newly diagnosed hypertensive patients and 40 controls were enrolled in the study. The entire study population underwent a comprehensive echocardiographic study including tissue synchrony imaging. The 12 segmental model was used to measure the time to regional peak systolic tissue velocity (Ts) in the LV and two dyssynchrony indices were computed. Parameters of AS including pulse wave velocity (PWV), augmentation index (AIx@75), and central systolic and diastolic BP were evaluated by applanation tonometry.
The baseline clinical and echocardiographic parameters of both groups were similar except for their BPs. Dyssynchrony indices were prolonged in patients with hypertension as compared to the controls. The standart deviation of Ts of 12 LV segments in patients with hypertension and the controls were 48.7±18.8 vs. 25.8±13.1, respectively (p<0.001), and the maximal difference in Ts between any 2 of 12 LV segments was 143.9±52.2 for hypertension patients vs. 83.8±39.4 for controls (p<0.001). PWV (11.9±2.5 vs. 9.5±1.4, p<0.001), AIx@75 (27.4±8.3 vs. 18.3±9, p=0.009), and central systolic (147.6±20.8 vs. 105.4±11, p<0.001) and diastolic (99.8±14.4 vs. 72.8±9.5, p<0.001) pressures were higher in patients with hypertension than in the controls, respectively. In multivariable analysis, central systolic BP (ß=0.496, p=0.03), LV mass index (ß=0.232, p=0.027), and body mass index (ß=0.308, p=0.002) were found to be independently related to dyssynchrony.
Central systolic BP is an independent predictor of LV dyssynchrony, but Aıx@75 did not have an independent effect on LV synchronicity in patients with newly-diagnosed hypertension.</description><subject>Adult</subject><subject>Aorta - physiology</subject><subject>Blood Pressure - physiology</subject><subject>Case-Control Studies</subject><subject>Echocardiography - methods</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Heart Ventricles - physiopathology</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Hypertension - physiopathology</subject><subject>Hypertrophy, Left Ventricular - complications</subject><subject>Hypertrophy, Left Ventricular - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity - complications</subject><subject>Pulse Wave Analysis</subject><subject>Vascular Stiffness - physiology</subject><issn>1016-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtPwzAYRT2AoILObMgjS1s_4jhhQajiJVVigTly7c9gSJ1gO5X6F_jVOLRgyQ9d3-8MB6ELSuZCFHyRPo2aM0LZnMlCFkdoQgktZ4KW9SmaxvhB8ipqToU8QaeM85LXBZmg73ulUxciVtaCTs6_4RZswlvwKTg9tCrguPP6PXTeaZd22Hn8vushJPDRbQH3KrlcjtdYBcg7QXCqxTE5az3ETPYG6xGX03XbdQb3IedDPjLMtkP-yxM35-jYqjbC9HCfodf7u5fl42z1_PC0vF3NNOdVmhWVqAAMEFNJ8fusjRE1kes1U8LmUCummGXKqrIihvISdEkoSCJLojg_Q1d7bh-6rwFiajYuamhb5aEbYkNZxSUTtRyri31Vhy7GALbpg9uosGsoaUbvzei9Gb03v97zxOUBPqw3YP77f8b5D_1jhR4</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Kırış, Abdulkadir</creator><creator>Kırış, Gülhanım</creator><creator>Karaman, Kayıhan</creator><creator>Sahin, Mürsel</creator><creator>Gedikli, Omer</creator><creator>Kaplan, Sahin</creator><creator>Orem, Asım</creator><creator>Kutlu, Merih</creator><creator>Kazaz, Zeynep</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121001</creationdate><title>Factors affecting left ventricular synchronicity in hypertensive patients: are arterial stiffness and central blood pressures influential?</title><author>Kırış, Abdulkadir ; Kırış, Gülhanım ; Karaman, Kayıhan ; Sahin, Mürsel ; Gedikli, Omer ; Kaplan, Sahin ; Orem, Asım ; Kutlu, Merih ; Kazaz, Zeynep</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-4858eede0d87558eed9dd5907bb2a5f875ca2a2f2afa680d136ec601e70760a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aorta - physiology</topic><topic>Blood Pressure - physiology</topic><topic>Case-Control Studies</topic><topic>Echocardiography - methods</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Heart Ventricles - physiopathology</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Hypertension - physiopathology</topic><topic>Hypertrophy, Left Ventricular - complications</topic><topic>Hypertrophy, Left Ventricular - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity - complications</topic><topic>Pulse Wave Analysis</topic><topic>Vascular Stiffness - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kırış, Abdulkadir</creatorcontrib><creatorcontrib>Kırış, Gülhanım</creatorcontrib><creatorcontrib>Karaman, Kayıhan</creatorcontrib><creatorcontrib>Sahin, Mürsel</creatorcontrib><creatorcontrib>Gedikli, Omer</creatorcontrib><creatorcontrib>Kaplan, Sahin</creatorcontrib><creatorcontrib>Orem, Asım</creatorcontrib><creatorcontrib>Kutlu, Merih</creatorcontrib><creatorcontrib>Kazaz, Zeynep</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Türk Kardiyoloji Derneği arşivi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kırış, Abdulkadir</au><au>Kırış, Gülhanım</au><au>Karaman, Kayıhan</au><au>Sahin, Mürsel</au><au>Gedikli, Omer</au><au>Kaplan, Sahin</au><au>Orem, Asım</au><au>Kutlu, Merih</au><au>Kazaz, Zeynep</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors affecting left ventricular synchronicity in hypertensive patients: are arterial stiffness and central blood pressures influential?</atitle><jtitle>Türk Kardiyoloji Derneği arşivi</jtitle><addtitle>Turk Kardiyol Dern Ars</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>40</volume><issue>7</issue><spage>581</spage><epage>588</epage><pages>581-588</pages><issn>1016-5169</issn><abstract>Left ventricular (LV) dyssynchrony is a common finding in patients with hypertension and is associated with LV hypertrophy. Arterial stiffness (AS) and central (aortic) blood pressures play a significant role in end-organ damage such as LV hypertrophy caused by hypertension. The objective of this study was to investigate the relationship between AS, central blood pressures (BP) and LV dyssynchrony.
Thirty-five newly diagnosed hypertensive patients and 40 controls were enrolled in the study. The entire study population underwent a comprehensive echocardiographic study including tissue synchrony imaging. The 12 segmental model was used to measure the time to regional peak systolic tissue velocity (Ts) in the LV and two dyssynchrony indices were computed. Parameters of AS including pulse wave velocity (PWV), augmentation index (AIx@75), and central systolic and diastolic BP were evaluated by applanation tonometry.
The baseline clinical and echocardiographic parameters of both groups were similar except for their BPs. Dyssynchrony indices were prolonged in patients with hypertension as compared to the controls. The standart deviation of Ts of 12 LV segments in patients with hypertension and the controls were 48.7±18.8 vs. 25.8±13.1, respectively (p<0.001), and the maximal difference in Ts between any 2 of 12 LV segments was 143.9±52.2 for hypertension patients vs. 83.8±39.4 for controls (p<0.001). PWV (11.9±2.5 vs. 9.5±1.4, p<0.001), AIx@75 (27.4±8.3 vs. 18.3±9, p=0.009), and central systolic (147.6±20.8 vs. 105.4±11, p<0.001) and diastolic (99.8±14.4 vs. 72.8±9.5, p<0.001) pressures were higher in patients with hypertension than in the controls, respectively. In multivariable analysis, central systolic BP (ß=0.496, p=0.03), LV mass index (ß=0.232, p=0.027), and body mass index (ß=0.308, p=0.002) were found to be independently related to dyssynchrony.
Central systolic BP is an independent predictor of LV dyssynchrony, but Aıx@75 did not have an independent effect on LV synchronicity in patients with newly-diagnosed hypertension.</abstract><cop>Turkey</cop><pmid>23363940</pmid><doi>10.5543/tkda.2012.27474</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aorta - physiology Blood Pressure - physiology Case-Control Studies Echocardiography - methods Electrocardiography Female Heart Ventricles - physiopathology Humans Hypertension - complications Hypertension - physiopathology Hypertrophy, Left Ventricular - complications Hypertrophy, Left Ventricular - physiopathology Male Middle Aged Obesity - complications Pulse Wave Analysis Vascular Stiffness - physiology |
| title | Factors affecting left ventricular synchronicity in hypertensive patients: are arterial stiffness and central blood pressures influential? |
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