Gold nanorods as dual photo-sensitizing and imaging agents for two-photon photodynamic therapy
Gold nanorods with three different aspect ratios were prepared and their dual capabilities for two-photon imaging and two-photon photodynamic therapy have been demonstrated. These gold nanorods exhibit large two-photon absorption action cross-sections, about two orders of magnitude larger than small...
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| Veröffentlicht in: | Nanoscale 2012-01, Vol.4 (24), p.7712-7719 |
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| container_issue | 24 |
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| container_title | Nanoscale |
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| creator | Zhao, Tingting Shen, Xiaoqin Li, Lin Guan, Zhenping Gao, Nengyue Yuan, Peiyan Yao, Shao Q Xu, Qing-Hua Xu, Guo Qin |
| description | Gold nanorods with three different aspect ratios were prepared and their dual capabilities for two-photon imaging and two-photon photodynamic therapy have been demonstrated. These gold nanorods exhibit large two-photon absorption action cross-sections, about two orders of magnitude larger than small organic molecules, which makes them suitable for two-photon imaging. They can also effectively generate singlet oxygen under two-photon excitation, significantly higher than traditional photosensitizers such as Rose Bengal and Indocyanine Green. Such high singlet oxygen generation capability under two-photon excitation was ascribed to their large two-photon absorption cross-sections. Polyvinylpyrrolidone (PVP) coated gold nanorods displayed excellent biocompatibility and high cellular uptake efficiency. The two-photon photodynamic therapy effect and two-photon fluorescence imaging properties of PVP coated gold nanorods have been successfully demonstrated on HeLa cells in vitro using fluorescence microscopy and indirect XTT assay method. These gold nanorods thus hold great promise for imaging guided two-photon photodynamic therapy for the treatment of various malignant tumors. |
| doi_str_mv | 10.1039/c2nr32196c |
| format | Article |
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These gold nanorods exhibit large two-photon absorption action cross-sections, about two orders of magnitude larger than small organic molecules, which makes them suitable for two-photon imaging. They can also effectively generate singlet oxygen under two-photon excitation, significantly higher than traditional photosensitizers such as Rose Bengal and Indocyanine Green. Such high singlet oxygen generation capability under two-photon excitation was ascribed to their large two-photon absorption cross-sections. Polyvinylpyrrolidone (PVP) coated gold nanorods displayed excellent biocompatibility and high cellular uptake efficiency. The two-photon photodynamic therapy effect and two-photon fluorescence imaging properties of PVP coated gold nanorods have been successfully demonstrated on HeLa cells in vitro using fluorescence microscopy and indirect XTT assay method. These gold nanorods thus hold great promise for imaging guided two-photon photodynamic therapy for the treatment of various malignant tumors.</description><identifier>ISSN: 2040-3364</identifier><identifier>EISSN: 2040-3372</identifier><identifier>DOI: 10.1039/c2nr32196c</identifier><identifier>PMID: 23132010</identifier><language>eng</language><publisher>England</publisher><subject>Cell Survival - drug effects ; Excitation ; Fluorescence ; Gold ; Gold - chemistry ; HeLa Cells ; Humans ; Imaging ; Microscopy, Fluorescence ; Nanorods ; Nanostructure ; Nanotubes - chemistry ; Nanotubes - toxicity ; Photochemotherapy ; Photodynamic therapy ; Photons ; Photosensitizing Agents - chemistry ; Photosensitizing Agents - toxicity ; Povidone - chemistry ; Singlet oxygen ; Singlet Oxygen - metabolism</subject><ispartof>Nanoscale, 2012-01, Vol.4 (24), p.7712-7719</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-9bed0ce6e3df22af17ca68af51808960d5e006cb5f9facf7285631ae7f18d9383</citedby><cites>FETCH-LOGICAL-c427t-9bed0ce6e3df22af17ca68af51808960d5e006cb5f9facf7285631ae7f18d9383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23132010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Tingting</creatorcontrib><creatorcontrib>Shen, Xiaoqin</creatorcontrib><creatorcontrib>Li, Lin</creatorcontrib><creatorcontrib>Guan, Zhenping</creatorcontrib><creatorcontrib>Gao, Nengyue</creatorcontrib><creatorcontrib>Yuan, Peiyan</creatorcontrib><creatorcontrib>Yao, Shao Q</creatorcontrib><creatorcontrib>Xu, Qing-Hua</creatorcontrib><creatorcontrib>Xu, Guo Qin</creatorcontrib><title>Gold nanorods as dual photo-sensitizing and imaging agents for two-photon photodynamic therapy</title><title>Nanoscale</title><addtitle>Nanoscale</addtitle><description>Gold nanorods with three different aspect ratios were prepared and their dual capabilities for two-photon imaging and two-photon photodynamic therapy have been demonstrated. These gold nanorods exhibit large two-photon absorption action cross-sections, about two orders of magnitude larger than small organic molecules, which makes them suitable for two-photon imaging. They can also effectively generate singlet oxygen under two-photon excitation, significantly higher than traditional photosensitizers such as Rose Bengal and Indocyanine Green. Such high singlet oxygen generation capability under two-photon excitation was ascribed to their large two-photon absorption cross-sections. Polyvinylpyrrolidone (PVP) coated gold nanorods displayed excellent biocompatibility and high cellular uptake efficiency. The two-photon photodynamic therapy effect and two-photon fluorescence imaging properties of PVP coated gold nanorods have been successfully demonstrated on HeLa cells in vitro using fluorescence microscopy and indirect XTT assay method. These gold nanorods thus hold great promise for imaging guided two-photon photodynamic therapy for the treatment of various malignant tumors.</description><subject>Cell Survival - drug effects</subject><subject>Excitation</subject><subject>Fluorescence</subject><subject>Gold</subject><subject>Gold - chemistry</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Imaging</subject><subject>Microscopy, Fluorescence</subject><subject>Nanorods</subject><subject>Nanostructure</subject><subject>Nanotubes - chemistry</subject><subject>Nanotubes - toxicity</subject><subject>Photochemotherapy</subject><subject>Photodynamic therapy</subject><subject>Photons</subject><subject>Photosensitizing Agents - chemistry</subject><subject>Photosensitizing Agents - toxicity</subject><subject>Povidone - chemistry</subject><subject>Singlet oxygen</subject><subject>Singlet Oxygen - metabolism</subject><issn>2040-3364</issn><issn>2040-3372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkD1PwzAURS0EoqWw8AOQR4QUeLYTxxlRVQpSJRZYiVx_tEGJHexEqPx6QlvKyvTucO7V00HoksAtAVbcKeoCo6Tg6giNKaSQMJbT40Pm6QidxfgOwAvG2SkaUUYYBQJj9Db3tcZOOh-8jlhGrHtZ43btO59E42LVVV-VW2HpNK4audrmlXFdxNYH3H36ZAu7XUdvnGwqhbu1CbLdnKMTK-toLvZ3gl4fZi_Tx2TxPH-a3i8SldK8S4ql0aAMN0xbSqUluZJcSJsRAaLgoDMzPK-WmS2sVDanIuOMSJNbInTBBJug691uG_xHb2JXNlVUpq6lM76PJaGC5ZAR4P9AKWSDKJIO6M0OVcHHGIwt2zA4CJuSQPmjvvxTP8BX-91-2Rh9QH9ds2_MrIAj</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Zhao, Tingting</creator><creator>Shen, Xiaoqin</creator><creator>Li, Lin</creator><creator>Guan, Zhenping</creator><creator>Gao, Nengyue</creator><creator>Yuan, Peiyan</creator><creator>Yao, Shao Q</creator><creator>Xu, Qing-Hua</creator><creator>Xu, Guo Qin</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20120101</creationdate><title>Gold nanorods as dual photo-sensitizing and imaging agents for two-photon photodynamic therapy</title><author>Zhao, Tingting ; Shen, Xiaoqin ; Li, Lin ; Guan, Zhenping ; Gao, Nengyue ; Yuan, Peiyan ; Yao, Shao Q ; Xu, Qing-Hua ; Xu, Guo Qin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-9bed0ce6e3df22af17ca68af51808960d5e006cb5f9facf7285631ae7f18d9383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Cell Survival - drug effects</topic><topic>Excitation</topic><topic>Fluorescence</topic><topic>Gold</topic><topic>Gold - chemistry</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Imaging</topic><topic>Microscopy, Fluorescence</topic><topic>Nanorods</topic><topic>Nanostructure</topic><topic>Nanotubes - chemistry</topic><topic>Nanotubes - toxicity</topic><topic>Photochemotherapy</topic><topic>Photodynamic therapy</topic><topic>Photons</topic><topic>Photosensitizing Agents - chemistry</topic><topic>Photosensitizing Agents - toxicity</topic><topic>Povidone - chemistry</topic><topic>Singlet oxygen</topic><topic>Singlet Oxygen - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Tingting</creatorcontrib><creatorcontrib>Shen, Xiaoqin</creatorcontrib><creatorcontrib>Li, Lin</creatorcontrib><creatorcontrib>Guan, Zhenping</creatorcontrib><creatorcontrib>Gao, Nengyue</creatorcontrib><creatorcontrib>Yuan, Peiyan</creatorcontrib><creatorcontrib>Yao, Shao Q</creatorcontrib><creatorcontrib>Xu, Qing-Hua</creatorcontrib><creatorcontrib>Xu, Guo Qin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Nanoscale</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Tingting</au><au>Shen, Xiaoqin</au><au>Li, Lin</au><au>Guan, Zhenping</au><au>Gao, Nengyue</au><au>Yuan, Peiyan</au><au>Yao, Shao Q</au><au>Xu, Qing-Hua</au><au>Xu, Guo Qin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gold nanorods as dual photo-sensitizing and imaging agents for two-photon photodynamic therapy</atitle><jtitle>Nanoscale</jtitle><addtitle>Nanoscale</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>4</volume><issue>24</issue><spage>7712</spage><epage>7719</epage><pages>7712-7719</pages><issn>2040-3364</issn><eissn>2040-3372</eissn><abstract>Gold nanorods with three different aspect ratios were prepared and their dual capabilities for two-photon imaging and two-photon photodynamic therapy have been demonstrated. These gold nanorods exhibit large two-photon absorption action cross-sections, about two orders of magnitude larger than small organic molecules, which makes them suitable for two-photon imaging. They can also effectively generate singlet oxygen under two-photon excitation, significantly higher than traditional photosensitizers such as Rose Bengal and Indocyanine Green. Such high singlet oxygen generation capability under two-photon excitation was ascribed to their large two-photon absorption cross-sections. Polyvinylpyrrolidone (PVP) coated gold nanorods displayed excellent biocompatibility and high cellular uptake efficiency. The two-photon photodynamic therapy effect and two-photon fluorescence imaging properties of PVP coated gold nanorods have been successfully demonstrated on HeLa cells in vitro using fluorescence microscopy and indirect XTT assay method. These gold nanorods thus hold great promise for imaging guided two-photon photodynamic therapy for the treatment of various malignant tumors.</abstract><cop>England</cop><pmid>23132010</pmid><doi>10.1039/c2nr32196c</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Cell Survival - drug effects Excitation Fluorescence Gold Gold - chemistry HeLa Cells Humans Imaging Microscopy, Fluorescence Nanorods Nanostructure Nanotubes - chemistry Nanotubes - toxicity Photochemotherapy Photodynamic therapy Photons Photosensitizing Agents - chemistry Photosensitizing Agents - toxicity Povidone - chemistry Singlet oxygen Singlet Oxygen - metabolism |
| title | Gold nanorods as dual photo-sensitizing and imaging agents for two-photon photodynamic therapy |
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