Carbon nanotubes as nanocarriers in medicine
Carbon nanotubes (CNTs) possess outstanding properties and a unique physicochemical architecture, which may serve as an alternative platform for the delivery of various therapeutic molecules. This review focuses on recent progress in the field of CNTs for biomedical applications. After a short, gene...
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| Veröffentlicht in: | Current opinion in colloid & interface science 2012-12, Vol.17 (6), p.360-368 |
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| container_title | Current opinion in colloid & interface science |
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| creator | Peretz, Sivan Regev, Oren |
| description | Carbon nanotubes (CNTs) possess outstanding properties and a unique physicochemical architecture, which may serve as an alternative platform for the delivery of various therapeutic molecules. This review focuses on recent progress in the field of CNTs for biomedical applications. After a short, general physico-chemical introduction to CNTs, we introduce different methods for CNT surface modification, facilitating their dispersions in physiological solutions, on the one hand, and binding a wide range of molecules or drug-loaded liposomes, on the other. We summarize imaging evidences on the structure of CNT-drug conjugates and their relevant uptake mechanisms by the cell. Lastly, we review current repots on CNT toxicity and new developments in CNT-based medical applications: photo-thermal therapy, drug delivery and gene therapy.
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► CNTs are versatile tool for a wide range of biomedical applications. ► CNT-Liposome conjugate is an efficient platform for drug delivery. ► Surface modification, covalent or non-covalent, is essential in turning CNTs bio compatible. |
| doi_str_mv | 10.1016/j.cocis.2012.09.001 |
| format | Article |
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► CNTs are versatile tool for a wide range of biomedical applications. ► CNT-Liposome conjugate is an efficient platform for drug delivery. ► Surface modification, covalent or non-covalent, is essential in turning CNTs bio compatible.</description><subject>Carbon nanotubes</subject><subject>Chemistry</subject><subject>Colloidal state and disperse state</subject><subject>Dispersions</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Exact sciences and technology</subject><subject>Gene delivery</subject><subject>Gene therapy</subject><subject>General and physical chemistry</subject><subject>Imaging</subject><subject>Liposome</subject><subject>Medical</subject><subject>Membranes</subject><subject>Nano-carrier</subject><subject>Nanostructure</subject><subject>Photothermal therapy</subject><subject>Toxicity</subject><issn>1359-0294</issn><issn>1879-0399</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMoWKu_wMteBA_uOkm6yebgQYpfUPCi55BNJpDSZmuyFfz3ph9ePc0MPDPD-xByTaGhQMX9srGDDblhQFkDqgGgJ2RCO6lq4Eqdlp63pWdqdk4ucl5CIRhrJ-RublI_xCqaOIzbHnNl8n6wJqWAKVchVmt0wYaIl-TMm1XGq2Odks_np4_5a714f3mbPy5qy4UY6845B71zkjPrrGfSYUsduL7jDJU3pgfDvARX6F5QYaH1M8o6KTwqZSSfktvD3U0avraYR70O2eJqZSIO26wLy0WroOUF5QfUpiHnhF5vUlib9KMp6J0bvdR7N3rnRoPSJXnZujk-MNmalU8m7pC_VSaEmEnJCvdw4LCk_S46dLYBoy0-EtpRuyH8--cX5hx6ng</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Peretz, Sivan</creator><creator>Regev, Oren</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>20121201</creationdate><title>Carbon nanotubes as nanocarriers in medicine</title><author>Peretz, Sivan ; Regev, Oren</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-8ddd0bdd732cdcf27de51d0db832e9faab0a2f70d366b616c05f412876fe99a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Carbon nanotubes</topic><topic>Chemistry</topic><topic>Colloidal state and disperse state</topic><topic>Dispersions</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Exact sciences and technology</topic><topic>Gene delivery</topic><topic>Gene therapy</topic><topic>General and physical chemistry</topic><topic>Imaging</topic><topic>Liposome</topic><topic>Medical</topic><topic>Membranes</topic><topic>Nano-carrier</topic><topic>Nanostructure</topic><topic>Photothermal therapy</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peretz, Sivan</creatorcontrib><creatorcontrib>Regev, Oren</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Current opinion in colloid & interface science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peretz, Sivan</au><au>Regev, Oren</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carbon nanotubes as nanocarriers in medicine</atitle><jtitle>Current opinion in colloid & interface science</jtitle><date>2012-12-01</date><risdate>2012</risdate><volume>17</volume><issue>6</issue><spage>360</spage><epage>368</epage><pages>360-368</pages><issn>1359-0294</issn><eissn>1879-0399</eissn><abstract>Carbon nanotubes (CNTs) possess outstanding properties and a unique physicochemical architecture, which may serve as an alternative platform for the delivery of various therapeutic molecules. This review focuses on recent progress in the field of CNTs for biomedical applications. After a short, general physico-chemical introduction to CNTs, we introduce different methods for CNT surface modification, facilitating their dispersions in physiological solutions, on the one hand, and binding a wide range of molecules or drug-loaded liposomes, on the other. We summarize imaging evidences on the structure of CNT-drug conjugates and their relevant uptake mechanisms by the cell. Lastly, we review current repots on CNT toxicity and new developments in CNT-based medical applications: photo-thermal therapy, drug delivery and gene therapy.
[Display omitted]
► CNTs are versatile tool for a wide range of biomedical applications. ► CNT-Liposome conjugate is an efficient platform for drug delivery. ► Surface modification, covalent or non-covalent, is essential in turning CNTs bio compatible.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.cocis.2012.09.001</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 1359-0294 |
| ispartof | Current opinion in colloid & interface science, 2012-12, Vol.17 (6), p.360-368 |
| issn | 1359-0294 1879-0399 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Carbon nanotubes Chemistry Colloidal state and disperse state Dispersions Drug delivery Drug delivery systems Exact sciences and technology Gene delivery Gene therapy General and physical chemistry Imaging Liposome Medical Membranes Nano-carrier Nanostructure Photothermal therapy Toxicity |
| title | Carbon nanotubes as nanocarriers in medicine |
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