Loss of survivin in neural precursor cells results in impaired long-term potentiation in the dentate gyrus and CA1-region

Highlights ► Prenatal deletion of survivin results in deteriorated hippocampal synaptic plasticity. ► SurvivinCamcre mice show impaired long-term potentiation in the dentate gyrus and the Cornu Ammonis area 1-region. ► Basal hippocampal excitability and synaptic transmission are normal. ► Short-term...

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Veröffentlicht in:	Neuroscience 2013-02, Vol.231, p.413-419
Hauptverfasser:	Iscru, E, Ahmed, T, Coremans, V, Bozzi, Y, Caleo, M, Conway, E.M, D’Hooge, R, Balschun, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences CA1 Region, Hippocampal - metabolism CA1 Region, Hippocampal - physiology Central nervous system dentate gyrus Dentate Gyrus - metabolism Dentate Gyrus - physiology Electroencephalography Electrophysiology Excitatory Postsynaptic Potentials - physiology Fundamental and applied biological sciences. Psychology Inhibitor of Apoptosis Proteins - genetics Inhibitor of Apoptosis Proteins - metabolism Long-Term Potentiation - physiology LTP Mice Mice, Transgenic Neural Stem Cells - metabolism Neurogenesis Neurology Neurons - physiology picrotoxin Repressor Proteins - genetics Repressor Proteins - metabolism survivin Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights ► Prenatal deletion of survivin results in deteriorated hippocampal synaptic plasticity. ► SurvivinCamcre mice show impaired long-term potentiation in the dentate gyrus and the Cornu Ammonis area 1-region. ► Basal hippocampal excitability and synaptic transmission are normal. ► Short-term synaptic plasticity is unchanged. ► In addition to neurogenesis, survivin has a specific role in synaptic plasticity.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.10.049