Effect of ghrelin on brain edema induced by acute and chronic systemic hypoxia
► Systemic normobaric hypoxia increased brain water content in both acute and chronic hypoxia. ► Administration of ghrelin reduced brain water content only in acute hypoxia. ► Serum TNF-α levels increased in acute hypoxia and ghrelin could reduce it. ► Both acute and chronic systemic hypoxia decreas...
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| Veröffentlicht in: | Neuroscience letters 2013-02, Vol.534, p.47-51 |
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| creator | Hossienzadeh, Fezzeh Babri, Shirin Alipour, Mohammad Reza Ebrahimi, Hadi Mohaddes, Gisou |
| description | ► Systemic normobaric hypoxia increased brain water content in both acute and chronic hypoxia. ► Administration of ghrelin reduced brain water content only in acute hypoxia. ► Serum TNF-α levels increased in acute hypoxia and ghrelin could reduce it. ► Both acute and chronic systemic hypoxia decreased body weights. ► Administration of ghrelin prevented further weight loss in chronic hypoxia group.
Hypoxia is an important pathogenic factor for the induction of vascular leakage and brain edema formation. Recent studies suggest a role for TNF-α in the induction of brain edema. Ghrelin attenuates the synthesis of TNF-α following subarachnoid hemorrhage and traumatic brain injury (TBI). Therefore, we examined the effects of ghrelin on the brain edema, serum TNF-α levels and body weight in a systemic hypoxia model. Adult male Wistar rats were divided into acute and chronic controls, acute or chronic hypoxia and ghrelin-treated (80μg/kg/ip/daily) acute or chronic hypoxia groups. Systemic hypoxia was induced in rats by a normobaric hypoxic chamber (O2 11%) for two days (acute) or ten days (chronic). Effect of ghrelin on brain edema and serum TNF-α levels was assessed by dry–wet and ELISA method, respectively. The results showed that acute (P |
| doi_str_mv | 10.1016/j.neulet.2012.11.062 |
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Hypoxia is an important pathogenic factor for the induction of vascular leakage and brain edema formation. Recent studies suggest a role for TNF-α in the induction of brain edema. Ghrelin attenuates the synthesis of TNF-α following subarachnoid hemorrhage and traumatic brain injury (TBI). Therefore, we examined the effects of ghrelin on the brain edema, serum TNF-α levels and body weight in a systemic hypoxia model. Adult male Wistar rats were divided into acute and chronic controls, acute or chronic hypoxia and ghrelin-treated (80μg/kg/ip/daily) acute or chronic hypoxia groups. Systemic hypoxia was induced in rats by a normobaric hypoxic chamber (O2 11%) for two days (acute) or ten days (chronic). Effect of ghrelin on brain edema and serum TNF-α levels was assessed by dry–wet and ELISA method, respectively. The results showed that acute (P<0.001) and chronic (P<0.05) hypoxia caused an increase of brain water content. Administration of ghrelin only in the acute hypoxia group significantly (P<0.001) reduced brain water content. Acute hypoxia caused an increase of serum TNF-α level (P<0.001) and ghrelin significantly (P<0.001) reduced it. TNF-α level in chronic hypoxia did not change significantly. Both acute and chronic hypoxia decreased body weight significantly (P<0.001) and administration of ghrelin only could prevent further weight loss in chronic hypoxia group (P<0.001). Our findings show that administration of ghrelin may be useful in reducing brain edema induced by acute systemic hypoxia and at least part of the anti-edematous effects of ghrelin is due to decrease of serum TNF-α levels.]]></description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2012.11.062</identifier><identifier>PMID: 23295905</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Acute Disease ; Animals ; Body Weight - drug effects ; Brain edema ; Brain Edema - blood ; Brain Edema - drug therapy ; Brain Edema - etiology ; Chronic Disease ; Ghrelin ; Ghrelin - pharmacology ; Ghrelin - therapeutic use ; Hypoxia ; Hypoxia - complications ; Male ; Rat ; Rats ; Rats, Wistar ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Neuroscience letters, 2013-02, Vol.534, p.47-51</ispartof><rights>2013 Elsevier Ireland Ltd</rights><rights>Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-f7094d4bbfffd5175d32f686c55f7cc37426839284be7f8fc16af2721475c7a13</citedby><cites>FETCH-LOGICAL-c362t-f7094d4bbfffd5175d32f686c55f7cc37426839284be7f8fc16af2721475c7a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2012.11.062$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23295905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hossienzadeh, Fezzeh</creatorcontrib><creatorcontrib>Babri, Shirin</creatorcontrib><creatorcontrib>Alipour, Mohammad Reza</creatorcontrib><creatorcontrib>Ebrahimi, Hadi</creatorcontrib><creatorcontrib>Mohaddes, Gisou</creatorcontrib><title>Effect of ghrelin on brain edema induced by acute and chronic systemic hypoxia</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description><![CDATA[► Systemic normobaric hypoxia increased brain water content in both acute and chronic hypoxia. ► Administration of ghrelin reduced brain water content only in acute hypoxia. ► Serum TNF-α levels increased in acute hypoxia and ghrelin could reduce it. ► Both acute and chronic systemic hypoxia decreased body weights. ► Administration of ghrelin prevented further weight loss in chronic hypoxia group.
Hypoxia is an important pathogenic factor for the induction of vascular leakage and brain edema formation. Recent studies suggest a role for TNF-α in the induction of brain edema. Ghrelin attenuates the synthesis of TNF-α following subarachnoid hemorrhage and traumatic brain injury (TBI). Therefore, we examined the effects of ghrelin on the brain edema, serum TNF-α levels and body weight in a systemic hypoxia model. Adult male Wistar rats were divided into acute and chronic controls, acute or chronic hypoxia and ghrelin-treated (80μg/kg/ip/daily) acute or chronic hypoxia groups. Systemic hypoxia was induced in rats by a normobaric hypoxic chamber (O2 11%) for two days (acute) or ten days (chronic). Effect of ghrelin on brain edema and serum TNF-α levels was assessed by dry–wet and ELISA method, respectively. The results showed that acute (P<0.001) and chronic (P<0.05) hypoxia caused an increase of brain water content. Administration of ghrelin only in the acute hypoxia group significantly (P<0.001) reduced brain water content. Acute hypoxia caused an increase of serum TNF-α level (P<0.001) and ghrelin significantly (P<0.001) reduced it. TNF-α level in chronic hypoxia did not change significantly. Both acute and chronic hypoxia decreased body weight significantly (P<0.001) and administration of ghrelin only could prevent further weight loss in chronic hypoxia group (P<0.001). Our findings show that administration of ghrelin may be useful in reducing brain edema induced by acute systemic hypoxia and at least part of the anti-edematous effects of ghrelin is due to decrease of serum TNF-α levels.]]></description><subject>Acute Disease</subject><subject>Animals</subject><subject>Body Weight - drug effects</subject><subject>Brain edema</subject><subject>Brain Edema - blood</subject><subject>Brain Edema - drug therapy</subject><subject>Brain Edema - etiology</subject><subject>Chronic Disease</subject><subject>Ghrelin</subject><subject>Ghrelin - pharmacology</subject><subject>Ghrelin - therapeutic use</subject><subject>Hypoxia</subject><subject>Hypoxia - complications</subject><subject>Male</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoMoOo6-gUiWblqTNGnajSDiDQbd6DqkyYmToZcxacW-vZFRl67Ov_gvnA-hM0pySmh5ucl7mFoYc0YoyynNScn20IJWkmWylmwfLUhBeFbUnByh4xg3hBBBBT9ER6xgtaiJWKCnW-fAjHhw-G0doPU9HnrcBJ0EWOg09r2dDFjczFibaQSse4vNOgy9NzjOcYQuifW8HT69PkEHTrcRTn_uEr3e3b7cPGSr5_vHm-tVZoqSjZmTpOaWN41zzgoqhS2YK6vSCOGkMYXkrKyKmlW8AekqZ2ipHZOMcimM1LRYootd7zYM7xPEUXU-Gmhb3cMwRUVZxVJBLatk5TurCUOMAZzaBt_pMCtK1DdJtVE7kuqbpKJUJZIpdv6zMDUd2L_QL7pkuNoZIP354SGoaDz0CZUPiaiyg_9_4QtmAYYW</recordid><startdate>20130208</startdate><enddate>20130208</enddate><creator>Hossienzadeh, Fezzeh</creator><creator>Babri, Shirin</creator><creator>Alipour, Mohammad Reza</creator><creator>Ebrahimi, Hadi</creator><creator>Mohaddes, Gisou</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130208</creationdate><title>Effect of ghrelin on brain edema induced by acute and chronic systemic hypoxia</title><author>Hossienzadeh, Fezzeh ; Babri, Shirin ; Alipour, Mohammad Reza ; Ebrahimi, Hadi ; Mohaddes, Gisou</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-f7094d4bbfffd5175d32f686c55f7cc37426839284be7f8fc16af2721475c7a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acute Disease</topic><topic>Animals</topic><topic>Body Weight - drug effects</topic><topic>Brain edema</topic><topic>Brain Edema - blood</topic><topic>Brain Edema - drug therapy</topic><topic>Brain Edema - etiology</topic><topic>Chronic Disease</topic><topic>Ghrelin</topic><topic>Ghrelin - pharmacology</topic><topic>Ghrelin - therapeutic use</topic><topic>Hypoxia</topic><topic>Hypoxia - complications</topic><topic>Male</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hossienzadeh, Fezzeh</creatorcontrib><creatorcontrib>Babri, Shirin</creatorcontrib><creatorcontrib>Alipour, Mohammad Reza</creatorcontrib><creatorcontrib>Ebrahimi, Hadi</creatorcontrib><creatorcontrib>Mohaddes, Gisou</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hossienzadeh, Fezzeh</au><au>Babri, Shirin</au><au>Alipour, Mohammad Reza</au><au>Ebrahimi, Hadi</au><au>Mohaddes, Gisou</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of ghrelin on brain edema induced by acute and chronic systemic hypoxia</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2013-02-08</date><risdate>2013</risdate><volume>534</volume><spage>47</spage><epage>51</epage><pages>47-51</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract><![CDATA[► Systemic normobaric hypoxia increased brain water content in both acute and chronic hypoxia. ► Administration of ghrelin reduced brain water content only in acute hypoxia. ► Serum TNF-α levels increased in acute hypoxia and ghrelin could reduce it. ► Both acute and chronic systemic hypoxia decreased body weights. ► Administration of ghrelin prevented further weight loss in chronic hypoxia group.
Hypoxia is an important pathogenic factor for the induction of vascular leakage and brain edema formation. Recent studies suggest a role for TNF-α in the induction of brain edema. Ghrelin attenuates the synthesis of TNF-α following subarachnoid hemorrhage and traumatic brain injury (TBI). Therefore, we examined the effects of ghrelin on the brain edema, serum TNF-α levels and body weight in a systemic hypoxia model. Adult male Wistar rats were divided into acute and chronic controls, acute or chronic hypoxia and ghrelin-treated (80μg/kg/ip/daily) acute or chronic hypoxia groups. Systemic hypoxia was induced in rats by a normobaric hypoxic chamber (O2 11%) for two days (acute) or ten days (chronic). Effect of ghrelin on brain edema and serum TNF-α levels was assessed by dry–wet and ELISA method, respectively. The results showed that acute (P<0.001) and chronic (P<0.05) hypoxia caused an increase of brain water content. Administration of ghrelin only in the acute hypoxia group significantly (P<0.001) reduced brain water content. Acute hypoxia caused an increase of serum TNF-α level (P<0.001) and ghrelin significantly (P<0.001) reduced it. TNF-α level in chronic hypoxia did not change significantly. Both acute and chronic hypoxia decreased body weight significantly (P<0.001) and administration of ghrelin only could prevent further weight loss in chronic hypoxia group (P<0.001). Our findings show that administration of ghrelin may be useful in reducing brain edema induced by acute systemic hypoxia and at least part of the anti-edematous effects of ghrelin is due to decrease of serum TNF-α levels.]]></abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>23295905</pmid><doi>10.1016/j.neulet.2012.11.062</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neuroscience letters, 2013-02, Vol.534, p.47-51 |
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| subjects | Acute Disease Animals Body Weight - drug effects Brain edema Brain Edema - blood Brain Edema - drug therapy Brain Edema - etiology Chronic Disease Ghrelin Ghrelin - pharmacology Ghrelin - therapeutic use Hypoxia Hypoxia - complications Male Rat Rats Rats, Wistar Tumor Necrosis Factor-alpha - metabolism |
| title | Effect of ghrelin on brain edema induced by acute and chronic systemic hypoxia |
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