Plasma Cyclophilin A Is a Novel Biomarker for Coronary Artery Disease
Background: Oxidative stress induces secretion of cyclophilin A (CyPA) from vascular smooth muscle cells and it plays a crucial role in the pathogenesis of atherosclerosis in mice. Therefore, we tested our hypothesis that plasma CyPA levels are increased in patients with coronary artery diseases (CA...
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| Veröffentlicht in: | Circulation Journal 2013, Vol.77(2), pp.447-455 |
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| creator | Satoh, Kimio Fukumoto, Yoshihiro Sugimura, Koichiro Miura, Yutaka Aoki, Tatsuo Nochioka, Kotaro Tatebe, Shunsuke Miyamichi-Yamamoto, Saori Shimizu, Toru Osaki, Shizuka Takagi, Yusuke Tsuburaya, Ryuji Ito, Yoshitaka Matsumoto, Yasuharu Nakayama, Masaharu Takeda, Morihiko Takahashi, Jun Ito, Kenta Yasuda, Satoshi Shimokawa, Hiroaki |
| description | Background: Oxidative stress induces secretion of cyclophilin A (CyPA) from vascular smooth muscle cells and it plays a crucial role in the pathogenesis of atherosclerosis in mice. Therefore, we tested our hypothesis that plasma CyPA levels are increased in patients with coronary artery diseases (CAD). Methods and Results: In 320 consecutive patients undergoing coronary angiography, we examined the relationship between plasma CyPA levels and the severity of CAD. We measured plasma CyPA by an immunoassay based on the sandwich technique. Plasma CyPA levels were significantly higher in patients with significant coronary stenosis compared to those without it (P |
| doi_str_mv | 10.1253/circj.CJ-12-0805 |
| format | Article |
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Therefore, we tested our hypothesis that plasma CyPA levels are increased in patients with coronary artery diseases (CAD). Methods and Results: In 320 consecutive patients undergoing coronary angiography, we examined the relationship between plasma CyPA levels and the severity of CAD. We measured plasma CyPA by an immunoassay based on the sandwich technique. Plasma CyPA levels were significantly higher in patients with significant coronary stenosis compared to those without it (P<0.001). A positive correlation was noted between plasma CyPA levels and significant coronary stenosis. The average number of stenotic coronary arteries and the need for coronary intervention were significantly increased in the quartiles of higher CyPA levels (both P<0.001). Indeed, the plasma CyPA level significantly correlated with the presence of CAD (adjusted odds ratio for CAD, 6.20; 95% confidence interval, 3.14–12.27; P<0.001). Interestingly, plasma levels of CyPA increased according to the number of atherosclerotic risk factors, all of which induce oxidative stress. Furthermore, plasma levels of CyPA significantly reduced after medical treatment of risk factors. Finally, CyPA was strongly expressed in coronary atherosclerotic plaque in patients with myocardial infarction. Conclusions: Plasma CyPA level is a novel biomarker for oxidative stress and CAD in humans. (Circ J 2013; 77: 447–455)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-12-0805</identifier><identifier>PMID: 23138189</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Aged ; Biomarker ; Biomarkers - blood ; Comorbidity ; Coronary Angiography ; Coronary artery disease ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - epidemiology ; Coronary Stenosis - blood ; Coronary Stenosis - diagnostic imaging ; Coronary Stenosis - epidemiology ; Cyclophilin A - blood ; Female ; Humans ; Male ; Middle Aged ; Odds Ratio ; Oxidative stress ; Prognosis ; Prospective Studies ; Risk Factors ; Sensitivity and Specificity ; Severity of Illness Index</subject><ispartof>Circulation Journal, 2013, Vol.77(2), pp.447-455</ispartof><rights>2013 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c642t-a326d105ad17860dcac1af8fd2c78b3da63c8b51447e8867c38def58534139ab3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23138189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Satoh, Kimio</creatorcontrib><creatorcontrib>Fukumoto, Yoshihiro</creatorcontrib><creatorcontrib>Sugimura, Koichiro</creatorcontrib><creatorcontrib>Miura, Yutaka</creatorcontrib><creatorcontrib>Aoki, Tatsuo</creatorcontrib><creatorcontrib>Nochioka, Kotaro</creatorcontrib><creatorcontrib>Tatebe, Shunsuke</creatorcontrib><creatorcontrib>Miyamichi-Yamamoto, Saori</creatorcontrib><creatorcontrib>Shimizu, Toru</creatorcontrib><creatorcontrib>Osaki, Shizuka</creatorcontrib><creatorcontrib>Takagi, Yusuke</creatorcontrib><creatorcontrib>Tsuburaya, Ryuji</creatorcontrib><creatorcontrib>Ito, Yoshitaka</creatorcontrib><creatorcontrib>Matsumoto, Yasuharu</creatorcontrib><creatorcontrib>Nakayama, Masaharu</creatorcontrib><creatorcontrib>Takeda, Morihiko</creatorcontrib><creatorcontrib>Takahashi, Jun</creatorcontrib><creatorcontrib>Ito, Kenta</creatorcontrib><creatorcontrib>Yasuda, Satoshi</creatorcontrib><creatorcontrib>Shimokawa, Hiroaki</creatorcontrib><title>Plasma Cyclophilin A Is a Novel Biomarker for Coronary Artery Disease</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background: Oxidative stress induces secretion of cyclophilin A (CyPA) from vascular smooth muscle cells and it plays a crucial role in the pathogenesis of atherosclerosis in mice. Therefore, we tested our hypothesis that plasma CyPA levels are increased in patients with coronary artery diseases (CAD). Methods and Results: In 320 consecutive patients undergoing coronary angiography, we examined the relationship between plasma CyPA levels and the severity of CAD. We measured plasma CyPA by an immunoassay based on the sandwich technique. Plasma CyPA levels were significantly higher in patients with significant coronary stenosis compared to those without it (P<0.001). A positive correlation was noted between plasma CyPA levels and significant coronary stenosis. The average number of stenotic coronary arteries and the need for coronary intervention were significantly increased in the quartiles of higher CyPA levels (both P<0.001). Indeed, the plasma CyPA level significantly correlated with the presence of CAD (adjusted odds ratio for CAD, 6.20; 95% confidence interval, 3.14–12.27; P<0.001). Interestingly, plasma levels of CyPA increased according to the number of atherosclerotic risk factors, all of which induce oxidative stress. Furthermore, plasma levels of CyPA significantly reduced after medical treatment of risk factors. Finally, CyPA was strongly expressed in coronary atherosclerotic plaque in patients with myocardial infarction. Conclusions: Plasma CyPA level is a novel biomarker for oxidative stress and CAD in humans. (Circ J 2013; 77: 447–455)</description><subject>Aged</subject><subject>Biomarker</subject><subject>Biomarkers - blood</subject><subject>Comorbidity</subject><subject>Coronary Angiography</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Stenosis - blood</subject><subject>Coronary Stenosis - diagnostic imaging</subject><subject>Coronary Stenosis - epidemiology</subject><subject>Cyclophilin A - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Oxidative stress</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtPwzAQhC0EoqVw54R85JLiRxI7xxJaaFUBBzhbG8ehKUlc7BSp_570QXvZ2ZW-GWkHoVtKhpRF_EGXTi-H6SygLCCSRGeoT3koglAycr7b4yCRIe-hK--XhLCERMkl6jFOuaQy6aPxewW-BpxudGVXi7IqGzzCU48Bv9pfU-HH0tbgvo3DhXU4tc424DZ45FrTyVPpDXhzjS4KqLy5OegAfU7GH-lLMH97nqajeaDjkLUBcBbnlESQUyFjkmvQFApZ5EwLmfEcYq5lFtEwFEbKWGguc1NEMuIh5QlkfIDu97krZ3_WxreqLr02VQWNsWuvKJNMchkK0aFkj2pnvXemUCtXdp9sFCVqW57alafSWXepbXmd5e6Qvs5qkx8N_211wGQPLH0LX-YIgGtLXZlDohCKbccp-QQswCnT8D-eSIPt</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Satoh, Kimio</creator><creator>Fukumoto, Yoshihiro</creator><creator>Sugimura, Koichiro</creator><creator>Miura, Yutaka</creator><creator>Aoki, Tatsuo</creator><creator>Nochioka, Kotaro</creator><creator>Tatebe, Shunsuke</creator><creator>Miyamichi-Yamamoto, Saori</creator><creator>Shimizu, Toru</creator><creator>Osaki, Shizuka</creator><creator>Takagi, Yusuke</creator><creator>Tsuburaya, Ryuji</creator><creator>Ito, Yoshitaka</creator><creator>Matsumoto, Yasuharu</creator><creator>Nakayama, Masaharu</creator><creator>Takeda, Morihiko</creator><creator>Takahashi, Jun</creator><creator>Ito, Kenta</creator><creator>Yasuda, Satoshi</creator><creator>Shimokawa, Hiroaki</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2013</creationdate><title>Plasma Cyclophilin A Is a Novel Biomarker for Coronary Artery Disease</title><author>Satoh, Kimio ; Fukumoto, Yoshihiro ; Sugimura, Koichiro ; Miura, Yutaka ; Aoki, Tatsuo ; Nochioka, Kotaro ; Tatebe, Shunsuke ; Miyamichi-Yamamoto, Saori ; Shimizu, Toru ; Osaki, Shizuka ; Takagi, Yusuke ; Tsuburaya, Ryuji ; Ito, Yoshitaka ; Matsumoto, Yasuharu ; Nakayama, Masaharu ; Takeda, Morihiko ; Takahashi, Jun ; Ito, Kenta ; Yasuda, Satoshi ; Shimokawa, Hiroaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c642t-a326d105ad17860dcac1af8fd2c78b3da63c8b51447e8867c38def58534139ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Biomarker</topic><topic>Biomarkers - blood</topic><topic>Comorbidity</topic><topic>Coronary Angiography</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Stenosis - blood</topic><topic>Coronary Stenosis - diagnostic imaging</topic><topic>Coronary Stenosis - epidemiology</topic><topic>Cyclophilin A - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Oxidative stress</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Satoh, Kimio</creatorcontrib><creatorcontrib>Fukumoto, Yoshihiro</creatorcontrib><creatorcontrib>Sugimura, Koichiro</creatorcontrib><creatorcontrib>Miura, Yutaka</creatorcontrib><creatorcontrib>Aoki, Tatsuo</creatorcontrib><creatorcontrib>Nochioka, Kotaro</creatorcontrib><creatorcontrib>Tatebe, Shunsuke</creatorcontrib><creatorcontrib>Miyamichi-Yamamoto, Saori</creatorcontrib><creatorcontrib>Shimizu, Toru</creatorcontrib><creatorcontrib>Osaki, Shizuka</creatorcontrib><creatorcontrib>Takagi, Yusuke</creatorcontrib><creatorcontrib>Tsuburaya, Ryuji</creatorcontrib><creatorcontrib>Ito, Yoshitaka</creatorcontrib><creatorcontrib>Matsumoto, Yasuharu</creatorcontrib><creatorcontrib>Nakayama, Masaharu</creatorcontrib><creatorcontrib>Takeda, Morihiko</creatorcontrib><creatorcontrib>Takahashi, Jun</creatorcontrib><creatorcontrib>Ito, Kenta</creatorcontrib><creatorcontrib>Yasuda, Satoshi</creatorcontrib><creatorcontrib>Shimokawa, Hiroaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Satoh, Kimio</au><au>Fukumoto, Yoshihiro</au><au>Sugimura, Koichiro</au><au>Miura, Yutaka</au><au>Aoki, Tatsuo</au><au>Nochioka, Kotaro</au><au>Tatebe, Shunsuke</au><au>Miyamichi-Yamamoto, Saori</au><au>Shimizu, Toru</au><au>Osaki, Shizuka</au><au>Takagi, Yusuke</au><au>Tsuburaya, Ryuji</au><au>Ito, Yoshitaka</au><au>Matsumoto, Yasuharu</au><au>Nakayama, Masaharu</au><au>Takeda, Morihiko</au><au>Takahashi, Jun</au><au>Ito, Kenta</au><au>Yasuda, Satoshi</au><au>Shimokawa, Hiroaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Cyclophilin A Is a Novel Biomarker for Coronary Artery Disease</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2013</date><risdate>2013</risdate><volume>77</volume><issue>2</issue><spage>447</spage><epage>455</epage><pages>447-455</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background: Oxidative stress induces secretion of cyclophilin A (CyPA) from vascular smooth muscle cells and it plays a crucial role in the pathogenesis of atherosclerosis in mice. Therefore, we tested our hypothesis that plasma CyPA levels are increased in patients with coronary artery diseases (CAD). Methods and Results: In 320 consecutive patients undergoing coronary angiography, we examined the relationship between plasma CyPA levels and the severity of CAD. We measured plasma CyPA by an immunoassay based on the sandwich technique. Plasma CyPA levels were significantly higher in patients with significant coronary stenosis compared to those without it (P<0.001). A positive correlation was noted between plasma CyPA levels and significant coronary stenosis. The average number of stenotic coronary arteries and the need for coronary intervention were significantly increased in the quartiles of higher CyPA levels (both P<0.001). Indeed, the plasma CyPA level significantly correlated with the presence of CAD (adjusted odds ratio for CAD, 6.20; 95% confidence interval, 3.14–12.27; P<0.001). Interestingly, plasma levels of CyPA increased according to the number of atherosclerotic risk factors, all of which induce oxidative stress. Furthermore, plasma levels of CyPA significantly reduced after medical treatment of risk factors. Finally, CyPA was strongly expressed in coronary atherosclerotic plaque in patients with myocardial infarction. Conclusions: Plasma CyPA level is a novel biomarker for oxidative stress and CAD in humans. (Circ J 2013; 77: 447–455)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>23138189</pmid><doi>10.1253/circj.CJ-12-0805</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biomarker Biomarkers - blood Comorbidity Coronary Angiography Coronary artery disease Coronary Artery Disease - blood Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - epidemiology Coronary Stenosis - blood Coronary Stenosis - diagnostic imaging Coronary Stenosis - epidemiology Cyclophilin A - blood Female Humans Male Middle Aged Odds Ratio Oxidative stress Prognosis Prospective Studies Risk Factors Sensitivity and Specificity Severity of Illness Index |
| title | Plasma Cyclophilin A Is a Novel Biomarker for Coronary Artery Disease |
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