Single whole blood dextran sulfate adsorption favorably affects systemic oxidative balance in lipoprotein apheresis patients
The acute changes of circulating oxidative stress parameters were compared in 16 patients undergoing two different apheresis techniques: plasma lipidfiltration (LF) or whole blood dextran sulfate adsorption (DSA). Immediately after apheresis LF was associated with an increase in systemic phagocyte c...
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| Veröffentlicht in: | Atherosclerosis. Supplements 2013-01, Vol.14 (1), p.157-160 |
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| container_title | Atherosclerosis. Supplements |
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| creator | Kopprasch, S. Bornstein, S.R. Schwarz, P.E.H. Bergmann, S. Julius, U. Graessler, J. |
| description | The acute changes of circulating oxidative stress parameters were compared in 16 patients undergoing two different apheresis techniques: plasma lipidfiltration (LF) or whole blood dextran sulfate adsorption (DSA).
Immediately after apheresis LF was associated with an increase in systemic phagocyte count, enhanced formation of reactive oxygen species and decreased activity of the antioxidant enzyme paraoxonase. After DSA, circulating phagocyte oxidant generating activity was significantly lower. Compared to LF, the systemic level of oxidized LDL and antioxLDL antibodies showed a larger decrease in DSA. All measured oxidative stress parameters returned to nearly pre-apheresis level at day three after apheresis,
The data show a more pronounced leukocyte activation immediately after LF in contrast to DSA, possibly as a consequence of necessity of prior separation of blood plasma. The pathophysiological importance of the short-term oxidative burden after a single apheresis session remains to be determined. |
| doi_str_mv | 10.1016/j.atherosclerosissup.2012.10.007 |
| format | Article |
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Immediately after apheresis LF was associated with an increase in systemic phagocyte count, enhanced formation of reactive oxygen species and decreased activity of the antioxidant enzyme paraoxonase. After DSA, circulating phagocyte oxidant generating activity was significantly lower. Compared to LF, the systemic level of oxidized LDL and antioxLDL antibodies showed a larger decrease in DSA. All measured oxidative stress parameters returned to nearly pre-apheresis level at day three after apheresis,
The data show a more pronounced leukocyte activation immediately after LF in contrast to DSA, possibly as a consequence of necessity of prior separation of blood plasma. The pathophysiological importance of the short-term oxidative burden after a single apheresis session remains to be determined.</description><identifier>ISSN: 1567-5688</identifier><identifier>EISSN: 1878-5050</identifier><identifier>DOI: 10.1016/j.atherosclerosissup.2012.10.007</identifier><identifier>PMID: 23357158</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Adsorption ; Aged ; Analysis of Variance ; Aryldialkylphosphatase - blood ; Autoantibodies - blood ; Biomarkers - blood ; Blood Component Removal - adverse effects ; Blood Component Removal - methods ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Dextran Sulfate - adverse effects ; Dextran Sulfate - therapeutic use ; Female ; Humans ; Hyperlipidemias - blood ; Hyperlipidemias - diagnosis ; Hyperlipidemias - immunology ; Hyperlipidemias - therapy ; Lipoprotein(a) - blood ; Lipoproteins - blood ; Lipoproteins - immunology ; Lipoproteins, LDL - blood ; Lipoproteins, LDL - immunology ; Male ; Middle Aged ; Oxidative Stress ; Phagocytes - metabolism ; Reactive Oxygen Species - blood ; Systemic oxidative and antioxidative potential ; Time Factors ; Treatment Outcome ; Triglycerides - blood ; Whole blood and plasma lipoprotein apheresis</subject><ispartof>Atherosclerosis. Supplements, 2013-01, Vol.14 (1), p.157-160</ispartof><rights>2012 Elsevier Ireland Ltd</rights><rights>Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-7f16cc92dee4c9f1f78c77c37a9de54ac67f41273ce486d1a0ae4ec4eea4b3833</citedby><cites>FETCH-LOGICAL-c398t-7f16cc92dee4c9f1f78c77c37a9de54ac67f41273ce486d1a0ae4ec4eea4b3833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1567568812000189$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23357158$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kopprasch, S.</creatorcontrib><creatorcontrib>Bornstein, S.R.</creatorcontrib><creatorcontrib>Schwarz, P.E.H.</creatorcontrib><creatorcontrib>Bergmann, S.</creatorcontrib><creatorcontrib>Julius, U.</creatorcontrib><creatorcontrib>Graessler, J.</creatorcontrib><title>Single whole blood dextran sulfate adsorption favorably affects systemic oxidative balance in lipoprotein apheresis patients</title><title>Atherosclerosis. Supplements</title><addtitle>Atheroscler Suppl</addtitle><description>The acute changes of circulating oxidative stress parameters were compared in 16 patients undergoing two different apheresis techniques: plasma lipidfiltration (LF) or whole blood dextran sulfate adsorption (DSA).
Immediately after apheresis LF was associated with an increase in systemic phagocyte count, enhanced formation of reactive oxygen species and decreased activity of the antioxidant enzyme paraoxonase. After DSA, circulating phagocyte oxidant generating activity was significantly lower. Compared to LF, the systemic level of oxidized LDL and antioxLDL antibodies showed a larger decrease in DSA. All measured oxidative stress parameters returned to nearly pre-apheresis level at day three after apheresis,
The data show a more pronounced leukocyte activation immediately after LF in contrast to DSA, possibly as a consequence of necessity of prior separation of blood plasma. The pathophysiological importance of the short-term oxidative burden after a single apheresis session remains to be determined.</description><subject>Adsorption</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Aryldialkylphosphatase - blood</subject><subject>Autoantibodies - blood</subject><subject>Biomarkers - blood</subject><subject>Blood Component Removal - adverse effects</subject><subject>Blood Component Removal - methods</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Dextran Sulfate - adverse effects</subject><subject>Dextran Sulfate - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperlipidemias - blood</subject><subject>Hyperlipidemias - diagnosis</subject><subject>Hyperlipidemias - immunology</subject><subject>Hyperlipidemias - therapy</subject><subject>Lipoprotein(a) - blood</subject><subject>Lipoproteins - blood</subject><subject>Lipoproteins - immunology</subject><subject>Lipoproteins, LDL - blood</subject><subject>Lipoproteins, LDL - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxidative Stress</subject><subject>Phagocytes - metabolism</subject><subject>Reactive Oxygen Species - blood</subject><subject>Systemic oxidative and antioxidative potential</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Triglycerides - blood</subject><subject>Whole blood and plasma lipoprotein apheresis</subject><issn>1567-5688</issn><issn>1878-5050</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU-PFCEQxYnRuOvqVzAc99IjNN0NfdNs_JtNPKhnUgOFy6SnaYEedxI_vDWZ1YsXLwUJv7x6vMfYtRQbKeTwareBeoc5FTedZixlXTatkC09b4TQj9ilNNo0vejFY7r3g276wZgL9qyUnRBCyrF_yi5apXote3PJfn2J8_cJ-c-7RHM7peS5x_uaYeZlnQJU5OBLykuNaeYBDinDdjpyCAFdLbwcS8V9dDzdRw81HkgFJpgd8jjzKS5pyaki3WEh60im-UIczrU8Z08CTAVfPJxX7Nu7t19vPjS3n99_vHlz2zg1mtroIAfnxtYjdm4MMmjjtHZKw-ix78ANOnSy1cphZwYvQQB26DpE6LbKKHXFrs-6ZOXHiqXafSwOJ7KJaS1WtqY1yrSqI_T1GXWUb8kY7JLjHvLRSmFPHdid_bcDe-rgRFAHJPHyYdu63aP_K_AndAI-nQGkPx8iZlsc5eHQx0yZWp_i_2_7DZvMqgA</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Kopprasch, S.</creator><creator>Bornstein, S.R.</creator><creator>Schwarz, P.E.H.</creator><creator>Bergmann, S.</creator><creator>Julius, U.</creator><creator>Graessler, J.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201301</creationdate><title>Single whole blood dextran sulfate adsorption favorably affects systemic oxidative balance in lipoprotein apheresis patients</title><author>Kopprasch, S. ; Bornstein, S.R. ; Schwarz, P.E.H. ; Bergmann, S. ; Julius, U. ; Graessler, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-7f16cc92dee4c9f1f78c77c37a9de54ac67f41273ce486d1a0ae4ec4eea4b3833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adsorption</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Aryldialkylphosphatase - blood</topic><topic>Autoantibodies - blood</topic><topic>Biomarkers - blood</topic><topic>Blood Component Removal - adverse effects</topic><topic>Blood Component Removal - methods</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Dextran Sulfate - adverse effects</topic><topic>Dextran Sulfate - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperlipidemias - blood</topic><topic>Hyperlipidemias - diagnosis</topic><topic>Hyperlipidemias - immunology</topic><topic>Hyperlipidemias - therapy</topic><topic>Lipoprotein(a) - blood</topic><topic>Lipoproteins - blood</topic><topic>Lipoproteins - immunology</topic><topic>Lipoproteins, LDL - blood</topic><topic>Lipoproteins, LDL - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxidative Stress</topic><topic>Phagocytes - metabolism</topic><topic>Reactive Oxygen Species - blood</topic><topic>Systemic oxidative and antioxidative potential</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Triglycerides - blood</topic><topic>Whole blood and plasma lipoprotein apheresis</topic><toplevel>online_resources</toplevel><creatorcontrib>Kopprasch, S.</creatorcontrib><creatorcontrib>Bornstein, S.R.</creatorcontrib><creatorcontrib>Schwarz, P.E.H.</creatorcontrib><creatorcontrib>Bergmann, S.</creatorcontrib><creatorcontrib>Julius, U.</creatorcontrib><creatorcontrib>Graessler, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis. Supplements</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kopprasch, S.</au><au>Bornstein, S.R.</au><au>Schwarz, P.E.H.</au><au>Bergmann, S.</au><au>Julius, U.</au><au>Graessler, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single whole blood dextran sulfate adsorption favorably affects systemic oxidative balance in lipoprotein apheresis patients</atitle><jtitle>Atherosclerosis. Supplements</jtitle><addtitle>Atheroscler Suppl</addtitle><date>2013-01</date><risdate>2013</risdate><volume>14</volume><issue>1</issue><spage>157</spage><epage>160</epage><pages>157-160</pages><issn>1567-5688</issn><eissn>1878-5050</eissn><abstract>The acute changes of circulating oxidative stress parameters were compared in 16 patients undergoing two different apheresis techniques: plasma lipidfiltration (LF) or whole blood dextran sulfate adsorption (DSA).
Immediately after apheresis LF was associated with an increase in systemic phagocyte count, enhanced formation of reactive oxygen species and decreased activity of the antioxidant enzyme paraoxonase. After DSA, circulating phagocyte oxidant generating activity was significantly lower. Compared to LF, the systemic level of oxidized LDL and antioxLDL antibodies showed a larger decrease in DSA. All measured oxidative stress parameters returned to nearly pre-apheresis level at day three after apheresis,
The data show a more pronounced leukocyte activation immediately after LF in contrast to DSA, possibly as a consequence of necessity of prior separation of blood plasma. The pathophysiological importance of the short-term oxidative burden after a single apheresis session remains to be determined.</abstract><cop>Netherlands</cop><pub>Elsevier Ireland Ltd</pub><pmid>23357158</pmid><doi>10.1016/j.atherosclerosissup.2012.10.007</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adsorption Aged Analysis of Variance Aryldialkylphosphatase - blood Autoantibodies - blood Biomarkers - blood Blood Component Removal - adverse effects Blood Component Removal - methods Cholesterol, HDL - blood Cholesterol, LDL - blood Dextran Sulfate - adverse effects Dextran Sulfate - therapeutic use Female Humans Hyperlipidemias - blood Hyperlipidemias - diagnosis Hyperlipidemias - immunology Hyperlipidemias - therapy Lipoprotein(a) - blood Lipoproteins - blood Lipoproteins - immunology Lipoproteins, LDL - blood Lipoproteins, LDL - immunology Male Middle Aged Oxidative Stress Phagocytes - metabolism Reactive Oxygen Species - blood Systemic oxidative and antioxidative potential Time Factors Treatment Outcome Triglycerides - blood Whole blood and plasma lipoprotein apheresis |
| title | Single whole blood dextran sulfate adsorption favorably affects systemic oxidative balance in lipoprotein apheresis patients |
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