Targeting triple-negative breast cancer through the somatostatin receptor with the new cytotoxic somatostatin analogue AN-162 [AEZS-124]

Previously, we have shown that the targeted cytotoxic somatostatin (sst) analogue AN-162 [AZSE-124] inhibits the growth of MDA-MB-231 human breast cancers xenografted into nude mice. In this study, we examined the trafficking of AN-162 into the cell, the expression of the somatostatin receptors (sst...

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Veröffentlicht in:	Anti-cancer drugs 2013-02, Vol.24 (2), p.150-157
Hauptverfasser:	Seitz, Stephan, Buchholz, Stefan, Schally, Andrew V, Jayakumar, Arumugam R, Weber, Florian, Papadia, Andrea, Rick, Ferenc G, Szalontay, Luca, Treszl, Andrea, Köster, Frank, Ortmann, Olaf, Hohla, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Hydroxyphenethylamine - analogs & derivatives 2-Hydroxyphenethylamine - pharmacology Aniline Compounds - pharmacology Animals Antineoplastic Agents - pharmacology Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Cell Death - drug effects Cell Nucleus - drug effects Cell Nucleus - metabolism Doxorubicin - pharmacology Female Humans Indexing in process Mice Mice, Nude Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone Receptors, Somatostatin - metabolism Tumor Cells, Cultured Xenograft Model Antitumor Assays
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