Altered GABAergic and glutamatergic activity within the rat hippocampus and amygdala in rats subjected to repeated corticosterone administration but not restraint stress

Highlights ► We studied the effect of corticosterone and restraint stress on GABA and glutamate. ► CORT decreased GAD65 and the α2 subunit and increased VGLUT2 in the hippocampus. ► CORT also decreased GAD67 and the α2 subunit in the amygdala. ► Restraint stress had no significant effect on these ma...

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Veröffentlicht in:	Neuroscience 2013-02, Vol.231, p.38-48
Hauptverfasser:	Lussier, A.L, Romay-Tallón, R, Caruncho, H.J, Kalynchuk, L.E
Format:	Artikel
Sprache:	eng
Schlagworte:	amygdala Amygdala - drug effects Amygdala - metabolism Animals Behavior, Animal - drug effects Behavior, Animal - physiology Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors corticosterone Corticosterone - administration & dosage Corticosterone - pharmacology Depression - metabolism Depressive Disorder - metabolism Disease Models, Animal Fundamental and applied biological sciences. Psychology GABA glutamate Glutamate Decarboxylase - metabolism hippocampus Hippocampus - drug effects Hippocampus - metabolism Male Neurology Rats Rats, Long-Evans Receptors, GABA-A - metabolism Restraint, Physical stress Stress, Physiological - physiology Vertebrates: nervous system and sense organs Vesicular Glutamate Transport Protein 2 - metabolism
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Zusammenfassung:	Highlights ► We studied the effect of corticosterone and restraint stress on GABA and glutamate. ► CORT decreased GAD65 and the α2 subunit and increased VGLUT2 in the hippocampus. ► CORT also decreased GAD67 and the α2 subunit in the amygdala. ► Restraint stress had no significant effect on these markers. ► GABA and glutamate may be neurobiological targets for novel antidepressant drugs.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.11.037