Smart Photothermal-Triggered Bilayer Phase Transition in AuNPs–Liposomes to Release Drug
Novel thermosensitive liposomes with embedded Au nanoparticles (AuNPs) in the liposome bilayer were prepared by a combination method of film build and supercritical CO2 incubation. These AuNPs–liposomes possess AuNPs that are embedded in the bilayer and a drug that is encapsulated in the central aqu...
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| Veröffentlicht in: | Langmuir 2013-01, Vol.29 (4), p.1061-1068 |
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| creator | An, Xueqin Zhan, Fan Zhu, Yinyan |
| description | Novel thermosensitive liposomes with embedded Au nanoparticles (AuNPs) in the liposome bilayer were prepared by a combination method of film build and supercritical CO2 incubation. These AuNPs–liposomes possess AuNPs that are embedded in the bilayer and a drug that is encapsulated in the central aqueous compartment. The AuNPs in the liposomes can strongly absorb light energy and efficiently convert the absorbed energy to heat. The localized heat induces a phase transition in the liposome bilayer and releases the drug. The drug release from the AuNPs–liposomes can be controlled by the irradiation time and AuNPs concentration in the AuNPs–liposomes at room temperature, where the AuNPs function as a nanoswitch for triggering drug release both spatially and temporally. The results suggest that drug release from the AuNPs–liposomes is due to a photothermic effect that induces phase transition of the liposomes rather than destruction of the liposome bilayer. |
| doi_str_mv | 10.1021/la304692h |
| format | Article |
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These AuNPs–liposomes possess AuNPs that are embedded in the bilayer and a drug that is encapsulated in the central aqueous compartment. The AuNPs in the liposomes can strongly absorb light energy and efficiently convert the absorbed energy to heat. The localized heat induces a phase transition in the liposome bilayer and releases the drug. The drug release from the AuNPs–liposomes can be controlled by the irradiation time and AuNPs concentration in the AuNPs–liposomes at room temperature, where the AuNPs function as a nanoswitch for triggering drug release both spatially and temporally. The results suggest that drug release from the AuNPs–liposomes is due to a photothermic effect that induces phase transition of the liposomes rather than destruction of the liposome bilayer.</description><identifier>ISSN: 0743-7463</identifier><identifier>EISSN: 1520-5827</identifier><identifier>DOI: 10.1021/la304692h</identifier><identifier>PMID: 23286691</identifier><identifier>CODEN: LANGD5</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Berberine - chemistry ; Carbon Dioxide - chemistry ; Chemistry ; Cholesterol - chemistry ; Colloidal state and disperse state ; Delayed-Action Preparations - chemistry ; Delayed-Action Preparations - radiation effects ; Diffusion ; Drug Compounding ; Exact sciences and technology ; General and physical chemistry ; Gold - chemistry ; Hydrophobic and Hydrophilic Interactions ; Kinetics ; Lecithins - chemistry ; Lipid Bilayers - chemistry ; Lipid Bilayers - radiation effects ; Liposomes - chemistry ; Liposomes - radiation effects ; Membranes ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - radiation effects ; Phase Transition ; Physical and chemical studies. Granulometry. Electrokinetic phenomena ; Temperature ; Ultraviolet Rays ; Water - chemistry</subject><ispartof>Langmuir, 2013-01, Vol.29 (4), p.1061-1068</ispartof><rights>Copyright © 2013 American Chemical Society</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a411t-64e30323e1ab4e3485c9a1fae7e16f4600f73b95fdd16d527efbaed2941742d73</citedby><cites>FETCH-LOGICAL-a411t-64e30323e1ab4e3485c9a1fae7e16f4600f73b95fdd16d527efbaed2941742d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/la304692h$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/la304692h$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27055,27903,27904,56716,56766</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27146100$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23286691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>An, Xueqin</creatorcontrib><creatorcontrib>Zhan, Fan</creatorcontrib><creatorcontrib>Zhu, Yinyan</creatorcontrib><title>Smart Photothermal-Triggered Bilayer Phase Transition in AuNPs–Liposomes to Release Drug</title><title>Langmuir</title><addtitle>Langmuir</addtitle><description>Novel thermosensitive liposomes with embedded Au nanoparticles (AuNPs) in the liposome bilayer were prepared by a combination method of film build and supercritical CO2 incubation. These AuNPs–liposomes possess AuNPs that are embedded in the bilayer and a drug that is encapsulated in the central aqueous compartment. The AuNPs in the liposomes can strongly absorb light energy and efficiently convert the absorbed energy to heat. The localized heat induces a phase transition in the liposome bilayer and releases the drug. The drug release from the AuNPs–liposomes can be controlled by the irradiation time and AuNPs concentration in the AuNPs–liposomes at room temperature, where the AuNPs function as a nanoswitch for triggering drug release both spatially and temporally. The results suggest that drug release from the AuNPs–liposomes is due to a photothermic effect that induces phase transition of the liposomes rather than destruction of the liposome bilayer.</description><subject>Berberine - chemistry</subject><subject>Carbon Dioxide - chemistry</subject><subject>Chemistry</subject><subject>Cholesterol - chemistry</subject><subject>Colloidal state and disperse state</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>Delayed-Action Preparations - radiation effects</subject><subject>Diffusion</subject><subject>Drug Compounding</subject><subject>Exact sciences and technology</subject><subject>General and physical chemistry</subject><subject>Gold - chemistry</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Kinetics</subject><subject>Lecithins - chemistry</subject><subject>Lipid Bilayers - chemistry</subject><subject>Lipid Bilayers - radiation effects</subject><subject>Liposomes - chemistry</subject><subject>Liposomes - radiation effects</subject><subject>Membranes</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metal Nanoparticles - radiation effects</subject><subject>Phase Transition</subject><subject>Physical and chemical studies. Granulometry. Electrokinetic phenomena</subject><subject>Temperature</subject><subject>Ultraviolet Rays</subject><subject>Water - chemistry</subject><issn>0743-7463</issn><issn>1520-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0LtOwzAUgGELgWgpDLwAyoIEQ8C32MlYylWqoIKysERuctK6SuJiJ0M33oE35Elw1dIuTD6SP50j_QidEnxFMCXXpWKYi4TO9lCXRBSHUUzlPupiyVkouWAddOTcHGOcMJ4cog5lNBYiIV308VYp2wSjmWlMMwNbqTIcWz2dgoU8uNGlWoL138pBMLaqdrrRpg50HfTb55H7-foe6oVxpgIXNCZ4hRJW9Na202N0UKjSwcnm7aH3-7vx4DEcvjw8DfrDUHFCmlBwYJhRBkRN_MjjKEsUKRRIIKLgAuNCskkSFXlORB5RCcVEQU4TTiSnuWQ9dLHeu7DmswXXpJV2GZSlqsG0LiU0pjGLaIQ9vVzTzBrnLBTpwmofYJkSnK5SptuU3p5t1raTCvKt_GvnwfkGKJepsvB1Mu12ThIuCMY7pzKXzk1ra1_jn4O_rMSIFw</recordid><startdate>20130129</startdate><enddate>20130129</enddate><creator>An, Xueqin</creator><creator>Zhan, Fan</creator><creator>Zhu, Yinyan</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130129</creationdate><title>Smart Photothermal-Triggered Bilayer Phase Transition in AuNPs–Liposomes to Release Drug</title><author>An, Xueqin ; Zhan, Fan ; Zhu, Yinyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a411t-64e30323e1ab4e3485c9a1fae7e16f4600f73b95fdd16d527efbaed2941742d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Berberine - chemistry</topic><topic>Carbon Dioxide - chemistry</topic><topic>Chemistry</topic><topic>Cholesterol - chemistry</topic><topic>Colloidal state and disperse state</topic><topic>Delayed-Action Preparations - chemistry</topic><topic>Delayed-Action Preparations - radiation effects</topic><topic>Diffusion</topic><topic>Drug Compounding</topic><topic>Exact sciences and technology</topic><topic>General and physical chemistry</topic><topic>Gold - chemistry</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>Kinetics</topic><topic>Lecithins - chemistry</topic><topic>Lipid Bilayers - chemistry</topic><topic>Lipid Bilayers - radiation effects</topic><topic>Liposomes - chemistry</topic><topic>Liposomes - radiation effects</topic><topic>Membranes</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Metal Nanoparticles - radiation effects</topic><topic>Phase Transition</topic><topic>Physical and chemical studies. Granulometry. Electrokinetic phenomena</topic><topic>Temperature</topic><topic>Ultraviolet Rays</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>An, Xueqin</creatorcontrib><creatorcontrib>Zhan, Fan</creatorcontrib><creatorcontrib>Zhu, Yinyan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Langmuir</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>An, Xueqin</au><au>Zhan, Fan</au><au>Zhu, Yinyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Smart Photothermal-Triggered Bilayer Phase Transition in AuNPs–Liposomes to Release Drug</atitle><jtitle>Langmuir</jtitle><addtitle>Langmuir</addtitle><date>2013-01-29</date><risdate>2013</risdate><volume>29</volume><issue>4</issue><spage>1061</spage><epage>1068</epage><pages>1061-1068</pages><issn>0743-7463</issn><eissn>1520-5827</eissn><coden>LANGD5</coden><abstract>Novel thermosensitive liposomes with embedded Au nanoparticles (AuNPs) in the liposome bilayer were prepared by a combination method of film build and supercritical CO2 incubation. These AuNPs–liposomes possess AuNPs that are embedded in the bilayer and a drug that is encapsulated in the central aqueous compartment. The AuNPs in the liposomes can strongly absorb light energy and efficiently convert the absorbed energy to heat. The localized heat induces a phase transition in the liposome bilayer and releases the drug. The drug release from the AuNPs–liposomes can be controlled by the irradiation time and AuNPs concentration in the AuNPs–liposomes at room temperature, where the AuNPs function as a nanoswitch for triggering drug release both spatially and temporally. The results suggest that drug release from the AuNPs–liposomes is due to a photothermic effect that induces phase transition of the liposomes rather than destruction of the liposome bilayer.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>23286691</pmid><doi>10.1021/la304692h</doi><tpages>8</tpages></addata></record> |
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| ispartof | Langmuir, 2013-01, Vol.29 (4), p.1061-1068 |
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| source | MEDLINE; ACS Publications |
| subjects | Berberine - chemistry Carbon Dioxide - chemistry Chemistry Cholesterol - chemistry Colloidal state and disperse state Delayed-Action Preparations - chemistry Delayed-Action Preparations - radiation effects Diffusion Drug Compounding Exact sciences and technology General and physical chemistry Gold - chemistry Hydrophobic and Hydrophilic Interactions Kinetics Lecithins - chemistry Lipid Bilayers - chemistry Lipid Bilayers - radiation effects Liposomes - chemistry Liposomes - radiation effects Membranes Metal Nanoparticles - chemistry Metal Nanoparticles - radiation effects Phase Transition Physical and chemical studies. Granulometry. Electrokinetic phenomena Temperature Ultraviolet Rays Water - chemistry |
| title | Smart Photothermal-Triggered Bilayer Phase Transition in AuNPs–Liposomes to Release Drug |
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