Randomized trial of chemoradiotherapy and adjuvant chemotherapy with nimustine (ACNU) versus nimustine plus procarbazine for newly diagnosed anaplastic astrocytoma and glioblastoma (JCOG0305)

Purpose Glioblastoma (GBM) is one of the worst cancers in terms of prognosis. Standard therapy consists of resection with concomitant chemoradiotherapy. Resistance to nimustine hydrochloride (ACNU), an alkylating agent, has been linked to methylguanine DNA methyltransferase (MGMT). Daily administrat...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2013-02, Vol.71 (2), p.511-521
Hauptverfasser:	Shibui, Soichiro, Narita, Yoshitaka, Mizusawa, Junki, Beppu, Takaaki, Ogasawara, Kuniaki, Sawamura, Yutaka, Kobayashi, Hiroyuki, Nishikawa, Ryo, Mishima, Kazuhiko, Muragaki, Yoshihiro, Maruyama, Takashi, Kuratsu, Junichi, Nakamura, Hideo, Kochi, Masato, Minamida, Yoshio, Yamaki, Toshiaki, Kumabe, Toshihiro, Tominaga, Teiji, Kayama, Takamasa, Sakurada, Kaori, Nagane, Motoo, Kobayashi, Keiichi, Nakamura, Hirohiko, Ito, Tamio, Yazaki, Takahito, Sasaki, Hikaru, Tanaka, Katsuyuki, Takahashi, Hideaki, Asai, Akio, Todo, Tomoki, Wakabayashi, Toshihiko, Takahashi, Jun, Takano, Shingo, Fujimaki, Takamitsu, Sumi, Minako, Miyakita, Yasuji, Nakazato, Yoichi, Sato, Akihiro, Fukuda, Haruhiko, Nomura, Kazuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Astrocytoma - mortality Astrocytoma - therapy Biological and medical sciences Brain Neoplasms - mortality Brain Neoplasms - therapy Cancer Research Chemoradiotherapy Chemotherapy, Adjuvant Disease-Free Survival Female Glioblastoma - drug therapy Glioblastoma - mortality Humans Male Medical sciences Medicine Medicine & Public Health Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neurology Nimustine - administration & dosage Nimustine - therapeutic use Oncology Original Article Pharmacology. Drug treatments Pharmacology/Toxicology Procarbazine - administration & dosage Procarbazine - therapeutic use Tumors Tumors of the nervous system. Phacomatoses
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