Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia
Waldenström macroglobulinemia (WM) is characterized by monoclonal gammopathy, usually IgM, in association with lymphoplasmacytic lymphoma (LPL). Little is known of the expression of nuclear proteins involved in B-cell development in LPL/WM. In this study, the expression patterns of PAX5/BSAP, MUM1/I...
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| Veröffentlicht in: | American journal of clinical pathology 2013-02, Vol.139 (2), p.210-219 |
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| creator | Roberts, Mark J Chadburn, Amy Ma, Shuo Hyjek, Elizabeth Peterson, LoAnn C |
| description | Waldenström macroglobulinemia (WM) is characterized by monoclonal gammopathy, usually IgM, in association with lymphoplasmacytic lymphoma (LPL). Little is known of the expression of nuclear proteins involved in B-cell development in LPL/WM. In this study, the expression patterns of PAX5/BSAP, MUM1/IRF4, and PRDM1/BLIMP1 were analyzed in plasma cells and lymphocytes in 29 cases of newly diagnosed LPL/WM by double immunohistochemical staining with CD138 and CD22. These patterns were compared with the expression profiles seen in normal bone marrow samples, reactive tonsils, and cases of plasma cell myeloma and marginal zone lymphoma. The median percentage of plasma cells coexpressing CD138 and PAX5 was significantly higher in LPL/WM compared with benign tissues (P = .001), marginal zone lymphoma (P = .002), and plasma cell myeloma (P < .0001), whereas the median percentage of plasma cells coexpressing CD138 and MUM1 was lower in LPL/WM than plasma cells in benign tissues (P = .02), marginal zone lymphoma (P = .001), and plasma cell myeloma (P = .0002). These findings show that a subset of plasma cells in LPL/WM demonstrates a nuclear protein expression pattern characteristic of the B-cell developmental program. Thus, the results better define the immunophenotypic profile of the neoplastic cells in LPL/WM. |
| doi_str_mv | 10.1309/AJCP0YGM8BLFYHJY |
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Little is known of the expression of nuclear proteins involved in B-cell development in LPL/WM. In this study, the expression patterns of PAX5/BSAP, MUM1/IRF4, and PRDM1/BLIMP1 were analyzed in plasma cells and lymphocytes in 29 cases of newly diagnosed LPL/WM by double immunohistochemical staining with CD138 and CD22. These patterns were compared with the expression profiles seen in normal bone marrow samples, reactive tonsils, and cases of plasma cell myeloma and marginal zone lymphoma. The median percentage of plasma cells coexpressing CD138 and PAX5 was significantly higher in LPL/WM compared with benign tissues (P = .001), marginal zone lymphoma (P = .002), and plasma cell myeloma (P < .0001), whereas the median percentage of plasma cells coexpressing CD138 and MUM1 was lower in LPL/WM than plasma cells in benign tissues (P = .02), marginal zone lymphoma (P = .001), and plasma cell myeloma (P = .0002). These findings show that a subset of plasma cells in LPL/WM demonstrates a nuclear protein expression pattern characteristic of the B-cell developmental program. Thus, the results better define the immunophenotypic profile of the neoplastic cells in LPL/WM.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1309/AJCP0YGM8BLFYHJY</identifier><identifier>PMID: 23355206</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Bone Marrow Cells - immunology ; Bone Marrow Cells - metabolism ; Bone Marrow Cells - pathology ; DNA-Binding Proteins - metabolism ; Female ; Humans ; Immunohistochemistry - methods ; Interferon Regulatory Factors - metabolism ; Lymphocytes - metabolism ; Lymphocytes - pathology ; Male ; Middle Aged ; PAX5 Transcription Factor - metabolism ; Plasma Cells - metabolism ; Plasma Cells - pathology ; Positive Regulatory Domain I-Binding Factor 1 ; Repressor Proteins - metabolism ; Sialic Acid Binding Ig-like Lectin 2 - metabolism ; Syndecan-1 - metabolism ; Waldenstrom Macroglobulinemia - metabolism ; Waldenstrom Macroglobulinemia - pathology</subject><ispartof>American journal of clinical pathology, 2013-02, Vol.139 (2), p.210-219</ispartof><rights>Copyright American Society for Clinical Pathology Feb 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c327t-e6a2212ea681205ce93ad4d935560db37077fbc8aed75a2fcbb2b8a726fe49ea3</citedby><cites>FETCH-LOGICAL-c327t-e6a2212ea681205ce93ad4d935560db37077fbc8aed75a2fcbb2b8a726fe49ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23355206$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roberts, Mark J</creatorcontrib><creatorcontrib>Chadburn, Amy</creatorcontrib><creatorcontrib>Ma, Shuo</creatorcontrib><creatorcontrib>Hyjek, Elizabeth</creatorcontrib><creatorcontrib>Peterson, LoAnn C</creatorcontrib><title>Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>Waldenström macroglobulinemia (WM) is characterized by monoclonal gammopathy, usually IgM, in association with lymphoplasmacytic lymphoma (LPL). Little is known of the expression of nuclear proteins involved in B-cell development in LPL/WM. In this study, the expression patterns of PAX5/BSAP, MUM1/IRF4, and PRDM1/BLIMP1 were analyzed in plasma cells and lymphocytes in 29 cases of newly diagnosed LPL/WM by double immunohistochemical staining with CD138 and CD22. These patterns were compared with the expression profiles seen in normal bone marrow samples, reactive tonsils, and cases of plasma cell myeloma and marginal zone lymphoma. The median percentage of plasma cells coexpressing CD138 and PAX5 was significantly higher in LPL/WM compared with benign tissues (P = .001), marginal zone lymphoma (P = .002), and plasma cell myeloma (P < .0001), whereas the median percentage of plasma cells coexpressing CD138 and MUM1 was lower in LPL/WM than plasma cells in benign tissues (P = .02), marginal zone lymphoma (P = .001), and plasma cell myeloma (P = .0002). These findings show that a subset of plasma cells in LPL/WM demonstrates a nuclear protein expression pattern characteristic of the B-cell developmental program. Thus, the results better define the immunophenotypic profile of the neoplastic cells in LPL/WM.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bone Marrow Cells - immunology</subject><subject>Bone Marrow Cells - metabolism</subject><subject>Bone Marrow Cells - pathology</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>Interferon Regulatory Factors - metabolism</subject><subject>Lymphocytes - metabolism</subject><subject>Lymphocytes - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>PAX5 Transcription Factor - metabolism</subject><subject>Plasma Cells - metabolism</subject><subject>Plasma Cells - pathology</subject><subject>Positive Regulatory Domain I-Binding Factor 1</subject><subject>Repressor Proteins - metabolism</subject><subject>Sialic Acid Binding Ig-like Lectin 2 - metabolism</subject><subject>Syndecan-1 - metabolism</subject><subject>Waldenstrom Macroglobulinemia - metabolism</subject><subject>Waldenstrom Macroglobulinemia - pathology</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdUE1Pg0AU3BiNrdW7J0PixQt29y2wcKyNbW3qx0EPnMgDlkqzsMhCDP_eNa0eenrJvJnJzBByzeg94zSaztbzNxovn8OHzSJereMTMmaRx10hAE7JmFIKbsQEH5ELY3aUMgipd05GwLnvAw3GJH7pMyWxdZpWd7KsnXwwrdz2CrtS144F1FA1n7pRaCrMhq7MDkiF029UuaxN1-rKsc9Wb5VOe1XWsirxkpwVqIy8OtwJ-Vg8vs9X7uZ1-TSfbdyMg-hcGSAAA4lByID6mYw45l4e2YABzVMuqBBFmoUoc-EjFFmaQhqigKCQXiSRT8jd3tc2-Oql6ZKqNJlUCmupe5PYzuCzgIXCUm-PqDvdt7VNlzDuiQBA8NCy6J5lCxk7RpE0bVlhOySMJr-zJ8ezW8nNwbhPK5n_C_525j_hTYFb</recordid><startdate>201302</startdate><enddate>201302</enddate><creator>Roberts, Mark J</creator><creator>Chadburn, Amy</creator><creator>Ma, Shuo</creator><creator>Hyjek, Elizabeth</creator><creator>Peterson, LoAnn C</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201302</creationdate><title>Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia</title><author>Roberts, Mark J ; Chadburn, Amy ; Ma, Shuo ; Hyjek, Elizabeth ; Peterson, LoAnn C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-e6a2212ea681205ce93ad4d935560db37077fbc8aed75a2fcbb2b8a726fe49ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bone Marrow Cells - immunology</topic><topic>Bone Marrow Cells - metabolism</topic><topic>Bone Marrow Cells - pathology</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry - methods</topic><topic>Interferon Regulatory Factors - metabolism</topic><topic>Lymphocytes - metabolism</topic><topic>Lymphocytes - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>PAX5 Transcription Factor - metabolism</topic><topic>Plasma Cells - metabolism</topic><topic>Plasma Cells - pathology</topic><topic>Positive Regulatory Domain I-Binding Factor 1</topic><topic>Repressor Proteins - metabolism</topic><topic>Sialic Acid Binding Ig-like Lectin 2 - metabolism</topic><topic>Syndecan-1 - metabolism</topic><topic>Waldenstrom Macroglobulinemia - metabolism</topic><topic>Waldenstrom Macroglobulinemia - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roberts, Mark J</creatorcontrib><creatorcontrib>Chadburn, Amy</creatorcontrib><creatorcontrib>Ma, Shuo</creatorcontrib><creatorcontrib>Hyjek, Elizabeth</creatorcontrib><creatorcontrib>Peterson, LoAnn C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roberts, Mark J</au><au>Chadburn, Amy</au><au>Ma, Shuo</au><au>Hyjek, Elizabeth</au><au>Peterson, LoAnn C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>2013-02</date><risdate>2013</risdate><volume>139</volume><issue>2</issue><spage>210</spage><epage>219</epage><pages>210-219</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><abstract>Waldenström macroglobulinemia (WM) is characterized by monoclonal gammopathy, usually IgM, in association with lymphoplasmacytic lymphoma (LPL). Little is known of the expression of nuclear proteins involved in B-cell development in LPL/WM. In this study, the expression patterns of PAX5/BSAP, MUM1/IRF4, and PRDM1/BLIMP1 were analyzed in plasma cells and lymphocytes in 29 cases of newly diagnosed LPL/WM by double immunohistochemical staining with CD138 and CD22. These patterns were compared with the expression profiles seen in normal bone marrow samples, reactive tonsils, and cases of plasma cell myeloma and marginal zone lymphoma. The median percentage of plasma cells coexpressing CD138 and PAX5 was significantly higher in LPL/WM compared with benign tissues (P = .001), marginal zone lymphoma (P = .002), and plasma cell myeloma (P < .0001), whereas the median percentage of plasma cells coexpressing CD138 and MUM1 was lower in LPL/WM than plasma cells in benign tissues (P = .02), marginal zone lymphoma (P = .001), and plasma cell myeloma (P = .0002). These findings show that a subset of plasma cells in LPL/WM demonstrates a nuclear protein expression pattern characteristic of the B-cell developmental program. Thus, the results better define the immunophenotypic profile of the neoplastic cells in LPL/WM.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>23355206</pmid><doi>10.1309/AJCP0YGM8BLFYHJY</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Aged, 80 and over Bone Marrow Cells - immunology Bone Marrow Cells - metabolism Bone Marrow Cells - pathology DNA-Binding Proteins - metabolism Female Humans Immunohistochemistry - methods Interferon Regulatory Factors - metabolism Lymphocytes - metabolism Lymphocytes - pathology Male Middle Aged PAX5 Transcription Factor - metabolism Plasma Cells - metabolism Plasma Cells - pathology Positive Regulatory Domain I-Binding Factor 1 Repressor Proteins - metabolism Sialic Acid Binding Ig-like Lectin 2 - metabolism Syndecan-1 - metabolism Waldenstrom Macroglobulinemia - metabolism Waldenstrom Macroglobulinemia - pathology |
| title | Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia |
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